Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors

Increased [18F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors

Abstract Background [18F]Fluoromisonidazole ([18F]FMISO) is a PET imaging probe widely used for the detection of hypoxia. We previously reported that [18F]FMISO is metabolized to the glutathione conjugate of the reduced form in hypoxic cells. In addition, we found that the [18F]FMISO uptake level va...

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Bibliographic Details
Main Authors: Yoichi Shimizu, Yukihiro Nakai, Hiroyuki Watanabe, Shimpei Iikuni, Masahiro Ono, Hideo Saji, Yuji Kuge, Tsuneo Saga, Yuji Nakamoto
Format: Article
Language:English
Published: SpringerOpen 2021-01-01
Series:EJNMMI Research
Subjects:
[18F]FMISO
Hypoxia
MRP1
Online Access:https://doi.org/10.1186/s13550-021-00752-3

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