Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo
Vitiligo is a skin pigmentation disorder caused by melanocyte damage or abnormal function. Reactive oxygen species (ROS) can cause oxidative stress damage to melanocytes, which in turn induces vitiligo. Traditional treatments such as phototherapy, drugs, and other methods of treatment are long and r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1293101/full |
| _version_ | 1797357510277988352 |
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| author | Rui-lin Yang Si-yu Chen Sheng-ping Fu De-zhi Zhao Wei-hong Wan Kang Yang Wei Lei Ying Yang Qian Zhang Tao Zhang Tao Zhang |
| author_facet | Rui-lin Yang Si-yu Chen Sheng-ping Fu De-zhi Zhao Wei-hong Wan Kang Yang Wei Lei Ying Yang Qian Zhang Tao Zhang Tao Zhang |
| author_sort | Rui-lin Yang |
| collection | DOAJ |
| description | Vitiligo is a skin pigmentation disorder caused by melanocyte damage or abnormal function. Reactive oxygen species (ROS) can cause oxidative stress damage to melanocytes, which in turn induces vitiligo. Traditional treatments such as phototherapy, drugs, and other methods of treatment are long and result in frequent recurrences. Currently, mesenchymal stem cells (MSCs) are widely used in the research of various disease treatments due to their excellent paracrine effects, making them a promising immunoregulatory and tissue repair strategy. Furthermore, an increasing body of evidence suggests that utilizing the paracrine functions of MSCs can downregulate oxidative stress in the testes, liver, kidneys, and other affected organs in animal models of certain diseases. Additionally, MSCs can help create a microenvironment that promotes tissue repair and regeneration in areas with oxidative stress damage, improving the disordered state of the injured site. In this article, we review the pathogenesis of oxidative stress in vitiligo and promising strategies for its treatment. |
| first_indexed | 2024-03-08T14:45:13Z |
| format | Article |
| id | doaj.art-a169bbc79a70492d8b47b32011cd877e |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-08T14:45:13Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a169bbc79a70492d8b47b32011cd877e2024-01-11T10:43:31ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-12-011110.3389/fcell.2023.12931011293101Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligoRui-lin Yang0Si-yu Chen1Sheng-ping Fu2De-zhi Zhao3Wei-hong Wan4Kang Yang5Wei Lei6Ying Yang7Qian Zhang8Tao Zhang9Tao Zhang10Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Human Anatomy, Zunyi Medical University, Zunyi, ChinaKey Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaDepartment of Dermatology, Affiliated Hospital of Zunyi Medical University, Zunyi, ChinaVitiligo is a skin pigmentation disorder caused by melanocyte damage or abnormal function. Reactive oxygen species (ROS) can cause oxidative stress damage to melanocytes, which in turn induces vitiligo. Traditional treatments such as phototherapy, drugs, and other methods of treatment are long and result in frequent recurrences. Currently, mesenchymal stem cells (MSCs) are widely used in the research of various disease treatments due to their excellent paracrine effects, making them a promising immunoregulatory and tissue repair strategy. Furthermore, an increasing body of evidence suggests that utilizing the paracrine functions of MSCs can downregulate oxidative stress in the testes, liver, kidneys, and other affected organs in animal models of certain diseases. Additionally, MSCs can help create a microenvironment that promotes tissue repair and regeneration in areas with oxidative stress damage, improving the disordered state of the injured site. In this article, we review the pathogenesis of oxidative stress in vitiligo and promising strategies for its treatment.https://www.frontiersin.org/articles/10.3389/fcell.2023.1293101/fullvitiligooxidative stressmelanocytemesenchymal stem cellsreactive oxygen speciesantioxidant |
| spellingShingle | Rui-lin Yang Si-yu Chen Sheng-ping Fu De-zhi Zhao Wei-hong Wan Kang Yang Wei Lei Ying Yang Qian Zhang Tao Zhang Tao Zhang Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo Frontiers in Cell and Developmental Biology vitiligo oxidative stress melanocyte mesenchymal stem cells reactive oxygen species antioxidant |
| title | Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo |
| title_full | Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo |
| title_fullStr | Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo |
| title_full_unstemmed | Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo |
| title_short | Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo |
| title_sort | antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo |
| topic | vitiligo oxidative stress melanocyte mesenchymal stem cells reactive oxygen species antioxidant |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1293101/full |
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