Activity of pemetrexed and high-dose gefitinib in an EGFR-mutated lung adenocarcinoma with brain and leptomeningeal metastasis after response to gefitinib

Activity of pemetrexed and high-dose gefitinib in an EGFR-mutated lung adenocarcinoma with brain and leptomeningeal metastasis after response to gefitinib

<p>Abstract</p> <p>About 20% to 40% of patients with non-small cell lung cancer (NSCLC) will develop brain metastases during the natural course of their disease. The prognosis for such patients is very poor with limited survival. In addition to the standard whole brain radiation th...

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Bibliographic Details
Main Authors: Yuan Ying, Tan Chunwen, Li Modan, Shen Hong, Fang Xuefeng, Hu Yinghong, Ma Shenglin
Format: Article
Language:English
Published: BMC 2012-11-01
Series:World Journal of Surgical Oncology
Subjects:
Non-small cell lung cancer
Pemetrexed
Epidermal growth factor receptor-tyrosine kinase inhibitors
Mutation
Online Access:http://www.wjso.com/content/10/1/235

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