[18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer
Breast cancer commonly metastasises to the skeleton, and stereotactic ablative body radiation therapy (SABR) is an emerging treatment for oligometastatic disease. Accurately imaging bone metastases and their response to treatment is challenging. [18F]NaF-PET has a higher sensitivity and specificity...
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Nuclear Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnume.2023.1197397/full |
| _version_ | 1797666529988313088 |
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| author | Nicholas Hardcastle Nicholas Hardcastle Nicholas Hardcastle Yang Liu Shankar Siva Shankar Siva Steven David Steven David |
| author_facet | Nicholas Hardcastle Nicholas Hardcastle Nicholas Hardcastle Yang Liu Shankar Siva Shankar Siva Steven David Steven David |
| author_sort | Nicholas Hardcastle |
| collection | DOAJ |
| description | Breast cancer commonly metastasises to the skeleton, and stereotactic ablative body radiation therapy (SABR) is an emerging treatment for oligometastatic disease. Accurately imaging bone metastases and their response to treatment is challenging. [18F]NaF-PET has a higher sensitivity and specificity than conventional bone scans for detecting breast cancer bone metastases. In this pre-defined secondary analysis of a prospective trial, we evaluated the change in [18F]NaF uptake after SABR. Patients with oligometastatic breast cancer received a single fraction of 20 Gy to up to three bone metastases. [18F]NaF-PET was acquired before and 12 months after SABR. Pre- and post-treatment [18F]NaF-PET images were registered to the treatment planning CT. The relative change in tumour SUVmax and SUVmean was quantified. The intersection of each of the radiation therapy isodose contours with a non-tumour bone was created. The change in SUVmean in sub-volumes of non-tumour bone receiving doses of 0–20 Gy was quantified. In total, 14 patients, with 17 bone metastases, were available for analysis. A total of 15 metastases exhibited a reduction in SUVmax; the median reduction was 42% and the maximum reduction 82%. An increased absolute reduction in SUVmax was observed with higher pre-treatment SUVmax. One patient exhibited increased SUVmax after treatment, which was attributed to normal peri-tumoural bone regeneration in the context of a bone metastasis. There was a median reduction of 15%–34% for non-tumour bone in each dose level. |
| first_indexed | 2024-03-11T20:00:39Z |
| format | Article |
| id | doaj.art-a16ed670cc134b90a2a186a720d09f61 |
| institution | Directory Open Access Journal |
| issn | 2673-8880 |
| language | English |
| last_indexed | 2024-03-11T20:00:39Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nuclear Medicine |
| spelling | doaj.art-a16ed670cc134b90a2a186a720d09f612023-10-04T09:27:28ZengFrontiers Media S.A.Frontiers in Nuclear Medicine2673-88802023-10-01310.3389/fnume.2023.11973971197397[18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancerNicholas Hardcastle0Nicholas Hardcastle1Nicholas Hardcastle2Yang Liu3Shankar Siva4Shankar Siva5Steven David6Steven David7Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, VIC, AustraliaSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, AustraliaWestern Health Victoria, Melbourne, VIC, AustraliaSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, AustraliaDepartment of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, AustraliaSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, AustraliaDepartment of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, AustraliaBreast cancer commonly metastasises to the skeleton, and stereotactic ablative body radiation therapy (SABR) is an emerging treatment for oligometastatic disease. Accurately imaging bone metastases and their response to treatment is challenging. [18F]NaF-PET has a higher sensitivity and specificity than conventional bone scans for detecting breast cancer bone metastases. In this pre-defined secondary analysis of a prospective trial, we evaluated the change in [18F]NaF uptake after SABR. Patients with oligometastatic breast cancer received a single fraction of 20 Gy to up to three bone metastases. [18F]NaF-PET was acquired before and 12 months after SABR. Pre- and post-treatment [18F]NaF-PET images were registered to the treatment planning CT. The relative change in tumour SUVmax and SUVmean was quantified. The intersection of each of the radiation therapy isodose contours with a non-tumour bone was created. The change in SUVmean in sub-volumes of non-tumour bone receiving doses of 0–20 Gy was quantified. In total, 14 patients, with 17 bone metastases, were available for analysis. A total of 15 metastases exhibited a reduction in SUVmax; the median reduction was 42% and the maximum reduction 82%. An increased absolute reduction in SUVmax was observed with higher pre-treatment SUVmax. One patient exhibited increased SUVmax after treatment, which was attributed to normal peri-tumoural bone regeneration in the context of a bone metastasis. There was a median reduction of 15%–34% for non-tumour bone in each dose level.https://www.frontiersin.org/articles/10.3389/fnume.2023.1197397/fullSAbRSBRTbreastbone metastasessodium fluoridenaF PET |
| spellingShingle | Nicholas Hardcastle Nicholas Hardcastle Nicholas Hardcastle Yang Liu Shankar Siva Shankar Siva Steven David Steven David [18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer Frontiers in Nuclear Medicine SAbR SBRT breast bone metastases sodium fluoride naF PET |
| title | [18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer |
| title_full | [18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer |
| title_fullStr | [18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer |
| title_full_unstemmed | [18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer |
| title_short | [18F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer |
| title_sort | 18f naf pet ct imaging of response to single fraction sabr to bone metastases from breast cancer |
| topic | SAbR SBRT breast bone metastases sodium fluoride naF PET |
| url | https://www.frontiersin.org/articles/10.3389/fnume.2023.1197397/full |
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