Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies

Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies

The enzyme reverse transcriptase (RT) plays a central role in the life cycle of human immunodeficiency virus (HIV), and RT has been an important drug target. Elucidations of the RT structures trapping and detailing the enzyme at various functional and conformational states by X-ray crystallography h...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Abhimanyu K. Singh, Kalyan Das
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	MDPI AG 2022-05-01
Loạt:	Viruses
Những chủ đề:	HIV-RT NRTI NNRTI drug design structural biology crystallography
Truy cập trực tuyến:	https://www.mdpi.com/1999-4915/14/5/1027

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