Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies

Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies

The enzyme reverse transcriptase (RT) plays a central role in the life cycle of human immunodeficiency virus (HIV), and RT has been an important drug target. Elucidations of the RT structures trapping and detailing the enzyme at various functional and conformational states by X-ray crystallography h...

書誌詳細
主要な著者:	Abhimanyu K. Singh, Kalyan Das
フォーマット:	論文
言語:	English
出版事項:	MDPI AG 2022-05-01
シリーズ:	Viruses
主題:	HIV-RT NRTI NNRTI drug design structural biology crystallography
オンライン･アクセス:	https://www.mdpi.com/1999-4915/14/5/1027

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