Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients
Bariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a significant percentage of patients do not experience improvement in fatty liver after BS, and more than 10% develop new or worsening NAFLD features. Therefore,...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/14/3187 |
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| author | Álvaro Pérez-Rubio Polina Soluyanova Erika Moro Guillermo Quintás Iván Rienda María Dolores Periañez Andrés Painel José Vizuete Judith Pérez-Rojas José V. Castell Ramón Trullenque-Juan Eugenia Pareja Ramiro Jover |
| author_facet | Álvaro Pérez-Rubio Polina Soluyanova Erika Moro Guillermo Quintás Iván Rienda María Dolores Periañez Andrés Painel José Vizuete Judith Pérez-Rojas José V. Castell Ramón Trullenque-Juan Eugenia Pareja Ramiro Jover |
| author_sort | Álvaro Pérez-Rubio |
| collection | DOAJ |
| description | Bariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a significant percentage of patients do not experience improvement in fatty liver after BS, and more than 10% develop new or worsening NAFLD features. Therefore, a question that remains unanswered is why some patients experience resolved NAFLD after BS and others do not. In this study, we investigated the fecal microbiota and plasma bile acids associated with NAFLD resolution in twelve morbidly obese patients undergoing BS, of whom six resolved their steatosis one year after surgery and another six did not. Results indicate that the hallmark of the gut microbiota in responder patients is a greater abundance of Bacteroides, Akkermansia, and several species of the Clostridia class (genera: Blautia, Faecalibacterium, Roseburia, Butyricicoccusa, and Clostridium), along with a decreased abundance of Actinomycetes/Bifidobacterium and Faecalicatena. NAFLD resolution was also associated with a sustained increase in primary bile acids (particularly non-conjugated), which likely results from a reduction in bacterial gut species capable of generating secondary bile acids. We conclude that there are specific changes in gut microbiota and plasma bile acids that could contribute to resolving NAFLD in BS patients. The knowledge acquired can help to design interventions with prebiotics and/or probiotics to promote a gut microbiome that favors NAFLD resolution. |
| first_indexed | 2024-03-11T00:46:11Z |
| format | Article |
| id | doaj.art-a170d0eaefee49e2953c33f3d1091aed |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:46:11Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a170d0eaefee49e2953c33f3d1091aed2023-11-18T20:48:31ZengMDPI AGNutrients2072-66432023-07-011514318710.3390/nu15143187Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery PatientsÁlvaro Pérez-Rubio0Polina Soluyanova1Erika Moro2Guillermo Quintás3Iván Rienda4María Dolores Periañez5Andrés Painel6José Vizuete7Judith Pérez-Rojas8José V. Castell9Ramón Trullenque-Juan10Eugenia Pareja11Ramiro Jover12Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario Dr. Peset, 46017 Valencia, SpainExperimental Hepatology Joint Unit, Health Research Institute La Fe-University of Valencia, 46026 Valencia, SpainExperimental Hepatology Joint Unit, Health Research Institute La Fe-University of Valencia, 46026 Valencia, SpainHealth and Biomedicine, Leitat Technological Center, 08225 Terrassa, SpainPathology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, SpainServicio de Cirugía General y Aparato Digestivo, Hospital Universitario Dr. Peset, 46017 Valencia, SpainSection of Abdominal Imaging, Radiology Department, Hospital Universitario Dr. Peset, 46017 Valencia, SpainSection of Abdominal Imaging, Radiology Department, Hospital Universitario Dr. Peset, 46017 Valencia, SpainPathology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, SpainExperimental Hepatology Joint Unit, Health Research Institute La Fe-University of Valencia, 46026 Valencia, SpainServicio de Cirugía General y Aparato Digestivo, Hospital Universitario Dr. Peset, 46017 Valencia, SpainServicio de Cirugía General y Aparato Digestivo, Hospital Universitario Dr. Peset, 46017 Valencia, SpainExperimental Hepatology Joint Unit, Health Research Institute La Fe-University of Valencia, 46026 Valencia, SpainBariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a significant percentage of patients do not experience improvement in fatty liver after BS, and more than 10% develop new or worsening NAFLD features. Therefore, a question that remains unanswered is why some patients experience resolved NAFLD after BS and others do not. In this study, we investigated the fecal microbiota and plasma bile acids associated with NAFLD resolution in twelve morbidly obese patients undergoing BS, of whom six resolved their steatosis one year after surgery and another six did not. Results indicate that the hallmark of the gut microbiota in responder patients is a greater abundance of Bacteroides, Akkermansia, and several species of the Clostridia class (genera: Blautia, Faecalibacterium, Roseburia, Butyricicoccusa, and Clostridium), along with a decreased abundance of Actinomycetes/Bifidobacterium and Faecalicatena. NAFLD resolution was also associated with a sustained increase in primary bile acids (particularly non-conjugated), which likely results from a reduction in bacterial gut species capable of generating secondary bile acids. We conclude that there are specific changes in gut microbiota and plasma bile acids that could contribute to resolving NAFLD in BS patients. The knowledge acquired can help to design interventions with prebiotics and/or probiotics to promote a gut microbiome that favors NAFLD resolution.https://www.mdpi.com/2072-6643/15/14/3187NAFLD resolutiongut microbiotabile acidbariatric surgerymorbid obesityBacteroides |
| spellingShingle | Álvaro Pérez-Rubio Polina Soluyanova Erika Moro Guillermo Quintás Iván Rienda María Dolores Periañez Andrés Painel José Vizuete Judith Pérez-Rojas José V. Castell Ramón Trullenque-Juan Eugenia Pareja Ramiro Jover Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients Nutrients NAFLD resolution gut microbiota bile acid bariatric surgery morbid obesity Bacteroides |
| title | Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients |
| title_full | Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients |
| title_fullStr | Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients |
| title_full_unstemmed | Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients |
| title_short | Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients |
| title_sort | gut microbiota and plasma bile acids associated with non alcoholic fatty liver disease resolution in bariatric surgery patients |
| topic | NAFLD resolution gut microbiota bile acid bariatric surgery morbid obesity Bacteroides |
| url | https://www.mdpi.com/2072-6643/15/14/3187 |
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