Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China
BackgroundRoutine HIV testing accompanied with pre-exposure prophylaxis (PrEP) requires innovative support in a real-world setting. ObjectiveThis study aimed to determine the usage of HIV self-testing (HIVST) kits and their secondary distribution to partners among...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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JMIR Publications
2021-08-01
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| Series: | Journal of Medical Internet Research |
| Online Access: | https://www.jmir.org/2021/8/e23978 |
| _version_ | 1797735754598711296 |
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| author | Jing Zhang Joseph Tucker Weiming Tang Hongyi Wang Zhenxing Chu Qinghai Hu Xiaojie Huang Yaokai Chen Hui Wang Xiaoqing He Yao Li Lukun Zhang Zhili Hu Rantong Bao Shangcao Li Hang Li Haibo Ding Yongjun Jiang Wenqing Geng Junjie Xu Hong Shang |
| author_facet | Jing Zhang Joseph Tucker Weiming Tang Hongyi Wang Zhenxing Chu Qinghai Hu Xiaojie Huang Yaokai Chen Hui Wang Xiaoqing He Yao Li Lukun Zhang Zhili Hu Rantong Bao Shangcao Li Hang Li Haibo Ding Yongjun Jiang Wenqing Geng Junjie Xu Hong Shang |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description |
BackgroundRoutine HIV testing accompanied with pre-exposure prophylaxis (PrEP) requires innovative support in a real-world setting.
ObjectiveThis study aimed to determine the usage of HIV self-testing (HIVST) kits and their secondary distribution to partners among men who have sex with men (MSM) in China, who use PrEP, in an observational study between 2018 and 2019.
MethodsIn 4 major cities in China, we prospectively followed-up MSM from the China Real-world oral PrEP demonstration study, which provides daily or on-demand PrEP for 12 months, to assess the usage and secondary distribution of HIVST on quarterly follow-ups. Half of the PrEP users were randomized to receive 2 HIVSTs per month in addition to quarterly facility-based HIV testing. We evaluated the feasibility of providing HIVST to PrEP users.
ResultsWe recruited 939 MSM and randomized 471 to receive HIVST, among whom 235 (49.9%) were daily and 236 (50.1%) were on-demand PrEP users. At baseline, the median age was 29 years, 390 (82.0%) men had at least college-level education, and 119 (25.3%) had never undergone facility-based HIV testing before. Three months after PrEP initiation, 341 (74.5%) men had used the HIVST provided to them and found it very easy to use. Among them, 180 of 341 (52.8%) men had distributed the HIVST kits it to other MSM, and 132 (51.6%) among the 256 men who returned HIVST results reported that used it with their sexual partners at the onset of intercourse. Participants on daily PrEP were more likely to use HIVST (adjusted hazard ratio=1.3, 95% CI 1.0-1.6) and distribute HIVST kits (adjusted hazard ratio=1.3, 95% CI 1.1-1.7) than those using on-demand PrEP.
ConclusionsMSM who used PrEP had a high rate of usage and secondary distribution of HIVST kits, especially among those on daily PrEP, which suggested high feasibility and necessity for HIVST after PrEP initiation. Assuming that fourth-generation HIVST kits are available, HIVST may be able to replace facility-based HIV testing to a certain extent.
Trial RegistrationChinese Clinical Trial Registry ChiCTR1800020374; https://www.chictr.org.cn/showprojen.aspx?proj=32481
International Registered Report Identifier (IRRID)RR2-10.1136/bmjopen-2019-036231 |
| first_indexed | 2024-03-12T13:03:40Z |
| format | Article |
| id | doaj.art-a17139299e3a4020857013d080fe3d62 |
| institution | Directory Open Access Journal |
| issn | 1438-8871 |
| language | English |
| last_indexed | 2024-03-12T13:03:40Z |
| publishDate | 2021-08-01 |
| publisher | JMIR Publications |
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| series | Journal of Medical Internet Research |
| spelling | doaj.art-a17139299e3a4020857013d080fe3d622023-08-28T18:34:53ZengJMIR PublicationsJournal of Medical Internet Research1438-88712021-08-01238e2397810.2196/23978Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From ChinaJing Zhanghttps://orcid.org/0000-0002-1759-1041Joseph Tuckerhttps://orcid.org/0000-0003-2804-1181Weiming Tanghttps://orcid.org/0000-0002-9026-707XHongyi Wanghttps://orcid.org/0000-0001-7791-0131Zhenxing Chuhttps://orcid.org/0000-0002-6398-2107Qinghai Huhttps://orcid.org/0000-0003-3654-8628Xiaojie Huanghttps://orcid.org/0000-0002-5045-9202Yaokai Chenhttps://orcid.org/0000-0002-3229-0108Hui Wanghttps://orcid.org/0000-0002-9524-8337Xiaoqing Hehttps://orcid.org/0000-0002-2134-3809Yao Lihttps://orcid.org/0000-0003-4330-6440Lukun Zhanghttps://orcid.org/0000-0001-8157-2227Zhili Huhttps://orcid.org/0000-0002-9574-6440Rantong Baohttps://orcid.org/0000-0002-4468-8404Shangcao Lihttps://orcid.org/0000-0003-0137-0727Hang Lihttps://orcid.org/0000-0001-9733-002XHaibo Dinghttps://orcid.org/0000-0002-9445-5473Yongjun Jianghttps://orcid.org/0000-0003-0166-7846Wenqing Genghttps://orcid.org/0000-0002-7008-9974Junjie Xuhttps://orcid.org/0000-0003-4303-7295Hong Shanghttps://orcid.org/0000-0001-5333-8943 BackgroundRoutine HIV testing accompanied with pre-exposure prophylaxis (PrEP) requires innovative support in a real-world setting. ObjectiveThis study aimed to determine the usage of HIV self-testing (HIVST) kits and their secondary distribution to partners among men who have sex with men (MSM) in China, who use PrEP, in an observational study between 2018 and 2019. MethodsIn 4 major cities in China, we prospectively followed-up MSM from the China Real-world oral PrEP demonstration study, which provides daily or on-demand PrEP for 12 months, to assess the usage and secondary distribution of HIVST on quarterly follow-ups. Half of the PrEP users were randomized to receive 2 HIVSTs per month in addition to quarterly facility-based HIV testing. We evaluated the feasibility of providing HIVST to PrEP users. ResultsWe recruited 939 MSM and randomized 471 to receive HIVST, among whom 235 (49.9%) were daily and 236 (50.1%) were on-demand PrEP users. At baseline, the median age was 29 years, 390 (82.0%) men had at least college-level education, and 119 (25.3%) had never undergone facility-based HIV testing before. Three months after PrEP initiation, 341 (74.5%) men had used the HIVST provided to them and found it very easy to use. Among them, 180 of 341 (52.8%) men had distributed the HIVST kits it to other MSM, and 132 (51.6%) among the 256 men who returned HIVST results reported that used it with their sexual partners at the onset of intercourse. Participants on daily PrEP were more likely to use HIVST (adjusted hazard ratio=1.3, 95% CI 1.0-1.6) and distribute HIVST kits (adjusted hazard ratio=1.3, 95% CI 1.1-1.7) than those using on-demand PrEP. ConclusionsMSM who used PrEP had a high rate of usage and secondary distribution of HIVST kits, especially among those on daily PrEP, which suggested high feasibility and necessity for HIVST after PrEP initiation. Assuming that fourth-generation HIVST kits are available, HIVST may be able to replace facility-based HIV testing to a certain extent. Trial RegistrationChinese Clinical Trial Registry ChiCTR1800020374; https://www.chictr.org.cn/showprojen.aspx?proj=32481 International Registered Report Identifier (IRRID)RR2-10.1136/bmjopen-2019-036231https://www.jmir.org/2021/8/e23978 |
| spellingShingle | Jing Zhang Joseph Tucker Weiming Tang Hongyi Wang Zhenxing Chu Qinghai Hu Xiaojie Huang Yaokai Chen Hui Wang Xiaoqing He Yao Li Lukun Zhang Zhili Hu Rantong Bao Shangcao Li Hang Li Haibo Ding Yongjun Jiang Wenqing Geng Junjie Xu Hong Shang Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China Journal of Medical Internet Research |
| title | Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China |
| title_full | Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China |
| title_fullStr | Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China |
| title_full_unstemmed | Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China |
| title_short | Internet-Based HIV Self-Testing Among Men Who Have Sex With Men Through Pre-exposure Prophylaxis: 3-Month Prospective Cohort Analysis From China |
| title_sort | internet based hiv self testing among men who have sex with men through pre exposure prophylaxis 3 month prospective cohort analysis from china |
| url | https://www.jmir.org/2021/8/e23978 |
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