Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns
BackgroundSerum albumin plays a pivotal role in regulating plasma oncotic pressure and modulating fluid distribution among various body compartments. Previous research examining the association between maternal serum albumin levels and fetal growth yielded limited and inconclusive findings. Therefor...
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1266669/full |
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| author | Jiayi Wu Jiayi Wu Jiayi Wu Xiaorui Liu Xiaorui Liu Xiaorui Liu Chuanmei Qin Chuanmei Qin Chuanmei Qin Jinwen Zhang Jinwen Zhang Jinwen Zhang Xueqing Liu Xueqing Liu Xueqing Liu Jianing Hu Jianing Hu Jianing Hu Fan Wu Fan Wu Fan Wu Cailian Chen Cailian Chen Yi Lin Yi Lin Yi Lin Yi Lin |
| author_facet | Jiayi Wu Jiayi Wu Jiayi Wu Xiaorui Liu Xiaorui Liu Xiaorui Liu Chuanmei Qin Chuanmei Qin Chuanmei Qin Jinwen Zhang Jinwen Zhang Jinwen Zhang Xueqing Liu Xueqing Liu Xueqing Liu Jianing Hu Jianing Hu Jianing Hu Fan Wu Fan Wu Fan Wu Cailian Chen Cailian Chen Yi Lin Yi Lin Yi Lin Yi Lin |
| author_sort | Jiayi Wu |
| collection | DOAJ |
| description | BackgroundSerum albumin plays a pivotal role in regulating plasma oncotic pressure and modulating fluid distribution among various body compartments. Previous research examining the association between maternal serum albumin levels and fetal growth yielded limited and inconclusive findings. Therefore, the specific influence of serum albumin on fetal growth remains poorly understood and warrants further investigation.MethodsA retrospective study involved 39200 women who had a singleton live birth at a tertiary-care academic medical center during the period from January 2017 to December 2020. Women were categorized into four groups according to the quartile of albumin concentration during early pregnancy: Q1 group, ≤41.0 g/L; Q2 group, 41.1-42.6 g/L; Q3 group, 42.7-44.3 g/L and Q4 group, >44.3 g/L. The main outcome measures were mid-term estimated fetal weight, birthweight and gestational age. Multivariate linear and logistic regression analysis were performed to detect the independent effect of maternal serum albumin level on fetal growth after adjusting for important confounding variables.ResultsIn the crude analysis, a significant inverse correlation was found between early pregnancy maternal serum albumin levels and fetal growth status, including mid-term ultrasound measurements, mid-term estimated fetal weight, birthweight, and gestational age. After adjustment for a number of confounding factors, mid-term estimated fetal weight, birthweight, and birth height decreased significantly with increasing albumin levels. Compared to the Q2 group, the Q4 group had higher rates of preterm birth (aOR, 1.16; 95% CI, 1.01–1.34), small-for-gestational-age (aOR, 1.27; 95% CI, 1.11–1.45) and low birthweight (aOR, 1.41; 95% CI, 1.18–1.69), and lower rate of large-for-gestational-age (aOR, 0.85; 95% CI, 0.78–0.94). Moreover, to achieve the optimal neonatal outcome, women with higher early pregnancy albumin levels required a greater reduction in albumin levels in later pregnancy stages.ConclusionsA higher maternal serum albumin level during early pregnancy was associated with poor fetal growth, with the detrimental effects becoming apparent as early as the mid-gestation period. These findings provided vital information for clinicians to predict fetal growth status and identify cases with a high risk of adverse neonatal outcomes early on. |
| first_indexed | 2024-03-07T15:47:43Z |
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| language | English |
| last_indexed | 2024-03-07T15:47:43Z |
| publishDate | 2024-03-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-a171414d1c744e96b5441c7f52b2675d2024-03-05T04:22:40ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-03-011510.3389/fendo.2024.12666691266669Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newbornsJiayi Wu0Jiayi Wu1Jiayi Wu2Xiaorui Liu3Xiaorui Liu4Xiaorui Liu5Chuanmei Qin6Chuanmei Qin7Chuanmei Qin8Jinwen Zhang9Jinwen Zhang10Jinwen Zhang11Xueqing Liu12Xueqing Liu13Xueqing Liu14Jianing Hu15Jianing Hu16Jianing Hu17Fan Wu18Fan Wu19Fan Wu20Cailian Chen21Cailian Chen22Yi Lin23Yi Lin24Yi Lin25Yi Lin26The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Automation, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai, ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaInstitute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaReproductive Medicine Center, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaBackgroundSerum albumin plays a pivotal role in regulating plasma oncotic pressure and modulating fluid distribution among various body compartments. Previous research examining the association between maternal serum albumin levels and fetal growth yielded limited and inconclusive findings. Therefore, the specific influence of serum albumin on fetal growth remains poorly understood and warrants further investigation.MethodsA retrospective study involved 39200 women who had a singleton live birth at a tertiary-care academic medical center during the period from January 2017 to December 2020. Women were categorized into four groups according to the quartile of albumin concentration during early pregnancy: Q1 group, ≤41.0 g/L; Q2 group, 41.1-42.6 g/L; Q3 group, 42.7-44.3 g/L and Q4 group, >44.3 g/L. The main outcome measures were mid-term estimated fetal weight, birthweight and gestational age. Multivariate linear and logistic regression analysis were performed to detect the independent effect of maternal serum albumin level on fetal growth after adjusting for important confounding variables.ResultsIn the crude analysis, a significant inverse correlation was found between early pregnancy maternal serum albumin levels and fetal growth status, including mid-term ultrasound measurements, mid-term estimated fetal weight, birthweight, and gestational age. After adjustment for a number of confounding factors, mid-term estimated fetal weight, birthweight, and birth height decreased significantly with increasing albumin levels. Compared to the Q2 group, the Q4 group had higher rates of preterm birth (aOR, 1.16; 95% CI, 1.01–1.34), small-for-gestational-age (aOR, 1.27; 95% CI, 1.11–1.45) and low birthweight (aOR, 1.41; 95% CI, 1.18–1.69), and lower rate of large-for-gestational-age (aOR, 0.85; 95% CI, 0.78–0.94). Moreover, to achieve the optimal neonatal outcome, women with higher early pregnancy albumin levels required a greater reduction in albumin levels in later pregnancy stages.ConclusionsA higher maternal serum albumin level during early pregnancy was associated with poor fetal growth, with the detrimental effects becoming apparent as early as the mid-gestation period. These findings provided vital information for clinicians to predict fetal growth status and identify cases with a high risk of adverse neonatal outcomes early on.https://www.frontiersin.org/articles/10.3389/fendo.2024.1266669/fullserum albuminfetal growthbirthweightgestational agemid-term fetal growth |
| spellingShingle | Jiayi Wu Jiayi Wu Jiayi Wu Xiaorui Liu Xiaorui Liu Xiaorui Liu Chuanmei Qin Chuanmei Qin Chuanmei Qin Jinwen Zhang Jinwen Zhang Jinwen Zhang Xueqing Liu Xueqing Liu Xueqing Liu Jianing Hu Jianing Hu Jianing Hu Fan Wu Fan Wu Fan Wu Cailian Chen Cailian Chen Yi Lin Yi Lin Yi Lin Yi Lin Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns Frontiers in Endocrinology serum albumin fetal growth birthweight gestational age mid-term fetal growth |
| title | Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns |
| title_full | Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns |
| title_fullStr | Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns |
| title_full_unstemmed | Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns |
| title_short | Effect of maternal serum albumin level on birthweight and gestational age: an analysis of 39200 singleton newborns |
| title_sort | effect of maternal serum albumin level on birthweight and gestational age an analysis of 39200 singleton newborns |
| topic | serum albumin fetal growth birthweight gestational age mid-term fetal growth |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1266669/full |
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