Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervals
To evaluate the immunogenicity of inactivated COVID-19 vaccines administered at different intervals. Subjects who had received two doses of inactivated COVID-19 vaccines at an interval of 21 days or 1–7 months were selected to collect 5 ml of venous blood after the second dose for the detection of s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-10-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2021.1945902 |
| _version_ | 1827806564418846720 |
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| author | Juan Li Weixin Chen Meng Chen Shuang Bai Qianli Yuan Jiang Wu |
| author_facet | Juan Li Weixin Chen Meng Chen Shuang Bai Qianli Yuan Jiang Wu |
| author_sort | Juan Li |
| collection | DOAJ |
| description | To evaluate the immunogenicity of inactivated COVID-19 vaccines administered at different intervals. Subjects who had received two doses of inactivated COVID-19 vaccines at an interval of 21 days or 1–7 months were selected to collect 5 ml of venous blood after the second dose for the detection of specific IgG antibody against SARS-CoV-2 using the chemiluminescent immunoassay. Blood samples were collected from 348 and 174 individuals vaccinated at an interval of 21 days or 1–7 months, respectively. Seropositive rate 2 weeks after two doses of vaccination at 21-days and 1–7 months interval was 95.7% and 97.1%, respectively, with no statistically significant difference. The post-vaccination antibody level was 23.7 with 21-days interval, higher than 14.2 with 1–7 months interval. Among the individuals vaccinated with two doses more than 1-month apart, seropositive rate was 98.5%, 90.0%, 91.7%, and 100% with 1- month (1–2 months, 2 months was not included, the same below), 2- month, 3- month, and 4–7 months of interval, respectively, and no statistically significant difference was observed. Appropriate extension of the vaccination interval between two doses of inactivated COVID-19 vaccine does not affect the production of specific IgG antibodies. The inactivated COVID-19 vaccine should be administered in accordance with the recommended vaccination schedule, and the vaccination interval can be extended appropriately under special circumstances. |
| first_indexed | 2024-03-11T21:42:56Z |
| format | Article |
| id | doaj.art-a1717ad8380e4156b70266b206e28f8f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:42:56Z |
| publishDate | 2021-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-a1717ad8380e4156b70266b206e28f8f2023-09-26T12:47:03ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-10-0117103310331310.1080/21645515.2021.19459021945902Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervalsJuan Li0Weixin Chen1Meng Chen2Shuang Bai3Qianli Yuan4Jiang Wu5Beijing Center for Preventive Medicine ResearchBeijing Center for Preventive Medicine ResearchBeijing Center for Preventive Medicine ResearchBeijing Center for Preventive Medicine ResearchBeijing Center for Preventive Medicine ResearchBeijing Center for Preventive Medicine ResearchTo evaluate the immunogenicity of inactivated COVID-19 vaccines administered at different intervals. Subjects who had received two doses of inactivated COVID-19 vaccines at an interval of 21 days or 1–7 months were selected to collect 5 ml of venous blood after the second dose for the detection of specific IgG antibody against SARS-CoV-2 using the chemiluminescent immunoassay. Blood samples were collected from 348 and 174 individuals vaccinated at an interval of 21 days or 1–7 months, respectively. Seropositive rate 2 weeks after two doses of vaccination at 21-days and 1–7 months interval was 95.7% and 97.1%, respectively, with no statistically significant difference. The post-vaccination antibody level was 23.7 with 21-days interval, higher than 14.2 with 1–7 months interval. Among the individuals vaccinated with two doses more than 1-month apart, seropositive rate was 98.5%, 90.0%, 91.7%, and 100% with 1- month (1–2 months, 2 months was not included, the same below), 2- month, 3- month, and 4–7 months of interval, respectively, and no statistically significant difference was observed. Appropriate extension of the vaccination interval between two doses of inactivated COVID-19 vaccine does not affect the production of specific IgG antibodies. The inactivated COVID-19 vaccine should be administered in accordance with the recommended vaccination schedule, and the vaccination interval can be extended appropriately under special circumstances.http://dx.doi.org/10.1080/21645515.2021.1945902inactivated covid-19 vaccinevaccination intervalimmunogenicity |
| spellingShingle | Juan Li Weixin Chen Meng Chen Shuang Bai Qianli Yuan Jiang Wu Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervals Human Vaccines & Immunotherapeutics inactivated covid-19 vaccine vaccination interval immunogenicity |
| title | Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervals |
| title_full | Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervals |
| title_fullStr | Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervals |
| title_full_unstemmed | Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervals |
| title_short | Immunogenicity of inactivated COVID-19 vaccines at different vaccination intervals |
| title_sort | immunogenicity of inactivated covid 19 vaccines at different vaccination intervals |
| topic | inactivated covid-19 vaccine vaccination interval immunogenicity |
| url | http://dx.doi.org/10.1080/21645515.2021.1945902 |
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