Biomarkers in Different Asthma Phenotypes
Asthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring the disease’s specific characteristics—biomarkers. The pathogenetic mechanisms are complex, and it is still a challenge to choose suitable biomarkers to adequately stratify pati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/12/6/801 |
| _version_ | 1797532812001148928 |
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| author | Sanja Popović-Grle Anamarija Štajduhar Marina Lampalo Dina Rnjak |
| author_facet | Sanja Popović-Grle Anamarija Štajduhar Marina Lampalo Dina Rnjak |
| author_sort | Sanja Popović-Grle |
| collection | DOAJ |
| description | Asthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring the disease’s specific characteristics—biomarkers. The pathogenetic mechanisms are complex, and it is still a challenge to choose suitable biomarkers to adequately stratify patients, which became especially important with the introduction of biologicals in asthma treatment. Usage of biomarkers and an understanding of the underlying pathobiological mechanisms lead to the definition of endotypes. Asthma can be broadly divided into two endotypes, T2-high and T2-low. The right combination of various biomarkers in different phenotypes is under investigation, hoping to help researchers and clinicians in better disease evaluation since theindividual approach and personalized medicine are imperative. Multiple biomarkers are superior to a single biomarker. |
| first_indexed | 2024-03-10T11:04:37Z |
| format | Article |
| id | doaj.art-a17242b3c3ab419a8adf2ff97861c7fb |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T11:04:37Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-a17242b3c3ab419a8adf2ff97861c7fb2023-11-21T21:14:24ZengMDPI AGGenes2073-44252021-05-0112680110.3390/genes12060801Biomarkers in Different Asthma PhenotypesSanja Popović-Grle0Anamarija Štajduhar1Marina Lampalo2Dina Rnjak3The Clinic for Lung Diseases Jordanovac, University Hospital Centre Zagreb, Jordanovac 104, 10 000 Zagreb, CroatiaThe Clinic for Lung Diseases Jordanovac, University Hospital Centre Zagreb, Jordanovac 104, 10 000 Zagreb, CroatiaThe Clinic for Lung Diseases Jordanovac, University Hospital Centre Zagreb, Jordanovac 104, 10 000 Zagreb, CroatiaThe Clinic for Lung Diseases Jordanovac, University Hospital Centre Zagreb, Jordanovac 104, 10 000 Zagreb, CroatiaAsthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring the disease’s specific characteristics—biomarkers. The pathogenetic mechanisms are complex, and it is still a challenge to choose suitable biomarkers to adequately stratify patients, which became especially important with the introduction of biologicals in asthma treatment. Usage of biomarkers and an understanding of the underlying pathobiological mechanisms lead to the definition of endotypes. Asthma can be broadly divided into two endotypes, T2-high and T2-low. The right combination of various biomarkers in different phenotypes is under investigation, hoping to help researchers and clinicians in better disease evaluation since theindividual approach and personalized medicine are imperative. Multiple biomarkers are superior to a single biomarker.https://www.mdpi.com/2073-4425/12/6/801asthma phenotypeclustersbiomarkerseosinophils |
| spellingShingle | Sanja Popović-Grle Anamarija Štajduhar Marina Lampalo Dina Rnjak Biomarkers in Different Asthma Phenotypes Genes asthma phenotype clusters biomarkers eosinophils |
| title | Biomarkers in Different Asthma Phenotypes |
| title_full | Biomarkers in Different Asthma Phenotypes |
| title_fullStr | Biomarkers in Different Asthma Phenotypes |
| title_full_unstemmed | Biomarkers in Different Asthma Phenotypes |
| title_short | Biomarkers in Different Asthma Phenotypes |
| title_sort | biomarkers in different asthma phenotypes |
| topic | asthma phenotype clusters biomarkers eosinophils |
| url | https://www.mdpi.com/2073-4425/12/6/801 |
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