Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy
Although photothermal therapy (PTT) have aroused substantial attention in the treatment of various types of tumors, the antitumor therapeutic efficacy is still unsatisfactory when using PTT alone. Very recently, oxygen-independent free-radical generation based on thermodynamic therapy (TDT) has emer...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522009042 |
| _version_ | 1797980237824262144 |
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| author | Xiangtian Deng Yitian Wang Renliang Zhao Zhen Zhang Xueling Yuan Zilu Ge Qian Fang Dong Wang Weijian Liu Wei Lin Guanglin Wang |
| author_facet | Xiangtian Deng Yitian Wang Renliang Zhao Zhen Zhang Xueling Yuan Zilu Ge Qian Fang Dong Wang Weijian Liu Wei Lin Guanglin Wang |
| author_sort | Xiangtian Deng |
| collection | DOAJ |
| description | Although photothermal therapy (PTT) have aroused substantial attention in the treatment of various types of tumors, the antitumor therapeutic efficacy is still unsatisfactory when using PTT alone. Very recently, oxygen-independent free-radical generation based on thermodynamic therapy (TDT) has emerged as a potential powerful therapeutic strategy for hypoxic cancer therapy. Herein, in this work, an intelligent hypoxia-independent free radical nanogenerator (CuS/AIPH@MnO2, denoted as CAM) was fabricated by in situ coating manganese dioxide (MnO2) shell onto the surface of as 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH)-loaded mesoporous hollow mesoporous copper sulfide (CuS). The local hyperthermal generated by CAM upon NIR laser irradiation not only permitted PTT, but also promoted the disintegration of AIPH for generation of oxygen-independent free radicals, exerting the advantages of combination therapy of PTT/TDT for effective tumor ablation. Simultaneously, both in vitro and in vivo results have demonstrated the synergistic therapeutic efficacy of PTT/TDT for remarkable tumor growth inhibition. In addition, the favorable biocompatibility and low cytotoxicity of the as-synthesized nanoparticles were verified both in vitro and in vivo. Collectively, this work proposed an attractive and promising strategy in cancer therapy based on generation of oxygen-irrelevant toxic free radicals, which exhibits great potential for clinical translations in hypoxic tumor therapy. |
| first_indexed | 2024-04-11T05:51:21Z |
| format | Article |
| id | doaj.art-a172d2be6b0643f88394caef120327cc |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-11T05:51:21Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-a172d2be6b0643f88394caef120327cc2022-12-22T04:42:04ZengElsevierMaterials & Design0264-12752022-12-01224111282Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapyXiangtian Deng0Yitian Wang1Renliang Zhao2Zhen Zhang3Xueling Yuan4Zilu Ge5Qian Fang6Dong Wang7Weijian Liu8Wei Lin9Guanglin Wang10Trauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, China; Orthopedics Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, ChinaOrthopedics Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, ChinaTrauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, China; Orthopedics Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, ChinaTrauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaTrauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaTrauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaTrauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaTrauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Corresponding authors.Department of Gynecology, West China Second Hospital, Sichuan University, Chengdu, China; Corresponding authors.Trauma Medical Center, Department of Orthopedics surgery, West China Hospital, Sichuan University, Chengdu 610041, China; Corresponding authors.Although photothermal therapy (PTT) have aroused substantial attention in the treatment of various types of tumors, the antitumor therapeutic efficacy is still unsatisfactory when using PTT alone. Very recently, oxygen-independent free-radical generation based on thermodynamic therapy (TDT) has emerged as a potential powerful therapeutic strategy for hypoxic cancer therapy. Herein, in this work, an intelligent hypoxia-independent free radical nanogenerator (CuS/AIPH@MnO2, denoted as CAM) was fabricated by in situ coating manganese dioxide (MnO2) shell onto the surface of as 2,2-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH)-loaded mesoporous hollow mesoporous copper sulfide (CuS). The local hyperthermal generated by CAM upon NIR laser irradiation not only permitted PTT, but also promoted the disintegration of AIPH for generation of oxygen-independent free radicals, exerting the advantages of combination therapy of PTT/TDT for effective tumor ablation. Simultaneously, both in vitro and in vivo results have demonstrated the synergistic therapeutic efficacy of PTT/TDT for remarkable tumor growth inhibition. In addition, the favorable biocompatibility and low cytotoxicity of the as-synthesized nanoparticles were verified both in vitro and in vivo. Collectively, this work proposed an attractive and promising strategy in cancer therapy based on generation of oxygen-irrelevant toxic free radicals, which exhibits great potential for clinical translations in hypoxic tumor therapy.http://www.sciencedirect.com/science/article/pii/S0264127522009042Hollow mesoporous copper sulfideManganese dioxide shellPhototherapyThermodynamic therapyOxygen-independent free radicals |
| spellingShingle | Xiangtian Deng Yitian Wang Renliang Zhao Zhen Zhang Xueling Yuan Zilu Ge Qian Fang Dong Wang Weijian Liu Wei Lin Guanglin Wang Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy Materials & Design Hollow mesoporous copper sulfide Manganese dioxide shell Phototherapy Thermodynamic therapy Oxygen-independent free radicals |
| title | Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy |
| title_full | Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy |
| title_fullStr | Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy |
| title_full_unstemmed | Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy |
| title_short | Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy |
| title_sort | tumor microenvironment nir responsive oxygen irrelevant radical nanogenerator for hypoxia independent photothermal thermodynamic osteosarcoma nanotherapy |
| topic | Hollow mesoporous copper sulfide Manganese dioxide shell Phototherapy Thermodynamic therapy Oxygen-independent free radicals |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522009042 |
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