Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection
Neuropsychiatric symptoms can be related to less common underlying neuropsychiatric conditions – in this case report, the condition discussed is that of grey matter heterotopia (GMH). The patient presented with a history of prominent aggression, impulsivity and manipulative and attention-seeking beh...
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| Format: | Article |
| Language: | English |
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AOSIS
2017-03-01
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| Series: | South African Journal of Psychiatry |
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| Online Access: | https://sajp.org.za/index.php/sajp/article/view/923 |
| _version_ | 1811335840431865856 |
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| author | Gian Lippi |
| author_facet | Gian Lippi |
| author_sort | Gian Lippi |
| collection | DOAJ |
| description | Neuropsychiatric symptoms can be related to less common underlying neuropsychiatric conditions – in this case report, the condition discussed is that of grey matter heterotopia (GMH). The patient presented with a history of prominent aggression, impulsivity and manipulative and attention-seeking behaviour. Episodes of depression and incidents of deliberate self-harm and suicide attempts had been reported. Neuropsychiatric symptoms included anxiety, a labile mood, delusional thinking and auditory hallucinations. Testing revealed some cognitive difficulties and severe impairment of frontal lobe functions. A magnetic resonance imaging (MRI) scan of his brain revealed the presence of GMH, which had previously been misdiagnosed as tuberous sclerosis. An MRI scan of the brain is the special investigation of choice for the correct diagnosis of GMH. The pathognomonic finding is that of heterotopic grey matter abnormally located within areas of white matter. Defective foetal neuronal migration between the third and fifth month of pregnancy can lead to GMH, which can present later on in childhood or adolescence with epilepsy, intellectual impairment or reading difficulties. During the late teenage years or early adulthood, a wide variety of neuropsychiatric symptoms may be present, which can lead to diagnostic difficulties. |
| first_indexed | 2024-04-13T17:30:48Z |
| format | Article |
| id | doaj.art-a173553136c14f77b9df8a4cbef38e3a |
| institution | Directory Open Access Journal |
| issn | 1608-9685 2078-6786 |
| language | English |
| last_indexed | 2024-04-13T17:30:48Z |
| publishDate | 2017-03-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Journal of Psychiatry |
| spelling | doaj.art-a173553136c14f77b9df8a4cbef38e3a2022-12-22T02:37:35ZengAOSISSouth African Journal of Psychiatry1608-96852078-67862017-03-0123010.4102/sajpsychiatry.v23i0.923362Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflectionGian Lippi0Department of Psychiatry, Faculty of Health Sciences, University of Pretoria, South Africa and Forensic Unit, Weskoppies HospitalNeuropsychiatric symptoms can be related to less common underlying neuropsychiatric conditions – in this case report, the condition discussed is that of grey matter heterotopia (GMH). The patient presented with a history of prominent aggression, impulsivity and manipulative and attention-seeking behaviour. Episodes of depression and incidents of deliberate self-harm and suicide attempts had been reported. Neuropsychiatric symptoms included anxiety, a labile mood, delusional thinking and auditory hallucinations. Testing revealed some cognitive difficulties and severe impairment of frontal lobe functions. A magnetic resonance imaging (MRI) scan of his brain revealed the presence of GMH, which had previously been misdiagnosed as tuberous sclerosis. An MRI scan of the brain is the special investigation of choice for the correct diagnosis of GMH. The pathognomonic finding is that of heterotopic grey matter abnormally located within areas of white matter. Defective foetal neuronal migration between the third and fifth month of pregnancy can lead to GMH, which can present later on in childhood or adolescence with epilepsy, intellectual impairment or reading difficulties. During the late teenage years or early adulthood, a wide variety of neuropsychiatric symptoms may be present, which can lead to diagnostic difficulties.https://sajp.org.za/index.php/sajp/article/view/923Grey matter heterotopiaSchizophrenianeuronal migration |
| spellingShingle | Gian Lippi Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection South African Journal of Psychiatry Grey matter heterotopia Schizophrenia neuronal migration |
| title | Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection |
| title_full | Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection |
| title_fullStr | Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection |
| title_full_unstemmed | Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection |
| title_short | Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection |
| title_sort | neuropsychiatric symptoms and diagnosis of grey matter heterotopia a case based reflection |
| topic | Grey matter heterotopia Schizophrenia neuronal migration |
| url | https://sajp.org.za/index.php/sajp/article/view/923 |
| work_keys_str_mv | AT gianlippi neuropsychiatricsymptomsanddiagnosisofgreymatterheterotopiaacasebasedreflection |