The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast
Background. Partial mastectomy is the method of choice for the surgical treatment of benign neoplasms (BN) of the breast. The drawback of this technique is the occurrence of residual cavities with the accumulation of serous and hemorrhagic exudate, promoting inflammation. Hydroxyethyl dimethyldihydr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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IP Habib O.N.
2023-12-01
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| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/viewFile/627193/142917 |
| _version_ | 1797290154258333696 |
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| author | Ramis M. Shabaev Sergey A. Khodyrev Irina V. Kolyadina Dmitry A. Blagovestnov Pavel M. Starokon |
| author_facet | Ramis M. Shabaev Sergey A. Khodyrev Irina V. Kolyadina Dmitry A. Blagovestnov Pavel M. Starokon |
| author_sort | Ramis M. Shabaev |
| collection | DOAJ |
| description | Background. Partial mastectomy is the method of choice for the surgical treatment of benign neoplasms (BN) of the breast. The drawback of this technique is the occurrence of residual cavities with the accumulation of serous and hemorrhagic exudate, promoting inflammation. Hydroxyethyl dimethyldihydropyrimidine (Ximedon) in the postoperative treatment improves the healing and overall treatment outcomes.
Materials and methods. The study included 101 patients. All of them had a partial mastectomy for the BN. The study patients received different pharmacotherapy in the postoperative period. They were divided into two groups depending on the use of hydroxyethyl dimethyldihydropyrimidine. Group 1 included 52 (51.5%) patients who received hydroxyethyl dimethyldihydropyrimidine 2 hours before surgery and 0.5 g on days 1 to 7 in the postoperative period. Group 2 included 49 (48.5%) patients who had not received hydroxyethyl dimethyldihydropyrimidine.
Results. Analysis of treatment outcomes showed that in group 1 patients receiving hydroxyethyl dimethyldihydropyrimidine, the overall treatment results were better. Therefore, hydroxyethyldimethyldihydropyrimidine improved overall treatment outcomes and increased patients' quality of life in the postoperative period.
Conclusion. The use of hydroxyethyldimethyldihydropyrimidine in the postoperative period, which has a protective effect at the cellular level due to membrane-stabilizing, antioxidant, adaptogenic, and antibacterial properties, is promising and improves wound healing, thus improving the overall results of surgical treatment of breast BNs. |
| first_indexed | 2024-03-07T19:16:21Z |
| format | Article |
| id | doaj.art-a173f94bbd3c4d3d840100bbdb8edf14 |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-03-07T19:16:21Z |
| publishDate | 2023-12-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-a173f94bbd3c4d3d840100bbdb8edf142024-02-29T13:31:29ZrusIP Habib O.N.Современная онкология1815-14341815-14422023-12-0125444044610.26442/18151434.2023.4.20251679543The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breastRamis M. Shabaev0https://orcid.org/0000-0002-0428-7454Sergey A. Khodyrev1https://orcid.org/0000-0002-9101-6029Irina V. Kolyadina2https://orcid.org/0000-0002-1124-6802Dmitry A. Blagovestnov3https://orcid.org/0000-0001-5724-6034Pavel M. Starokon4https://orcid.org/0000-0002-6512-9361Kirov Military Medical Academy – branch in MoscowKirov Military Medical Academy – branch in MoscowRussian Medical Academy of Continuous Professional EducationRussian Medical Academy of Continuous Professional EducationKirov Military Medical Academy – branch in MoscowBackground. Partial mastectomy is the method of choice for the surgical treatment of benign neoplasms (BN) of the breast. The drawback of this technique is the occurrence of residual cavities with the accumulation of serous and hemorrhagic exudate, promoting inflammation. Hydroxyethyl dimethyldihydropyrimidine (Ximedon) in the postoperative treatment improves the healing and overall treatment outcomes. Materials and methods. The study included 101 patients. All of them had a partial mastectomy for the BN. The study patients received different pharmacotherapy in the postoperative period. They were divided into two groups depending on the use of hydroxyethyl dimethyldihydropyrimidine. Group 1 included 52 (51.5%) patients who received hydroxyethyl dimethyldihydropyrimidine 2 hours before surgery and 0.5 g on days 1 to 7 in the postoperative period. Group 2 included 49 (48.5%) patients who had not received hydroxyethyl dimethyldihydropyrimidine. Results. Analysis of treatment outcomes showed that in group 1 patients receiving hydroxyethyl dimethyldihydropyrimidine, the overall treatment results were better. Therefore, hydroxyethyldimethyldihydropyrimidine improved overall treatment outcomes and increased patients' quality of life in the postoperative period. Conclusion. The use of hydroxyethyldimethyldihydropyrimidine in the postoperative period, which has a protective effect at the cellular level due to membrane-stabilizing, antioxidant, adaptogenic, and antibacterial properties, is promising and improves wound healing, thus improving the overall results of surgical treatment of breast BNs.https://modernonco.orscience.ru/1815-1434/article/viewFile/627193/142917benign neoplasm of the breastpartial mastectomyquality of lifehydroxyethyldimethyldihydropyrimidine |
| spellingShingle | Ramis M. Shabaev Sergey A. Khodyrev Irina V. Kolyadina Dmitry A. Blagovestnov Pavel M. Starokon The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast Современная онкология benign neoplasm of the breast partial mastectomy quality of life hydroxyethyldimethyldihydropyrimidine |
| title | The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast |
| title_full | The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast |
| title_fullStr | The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast |
| title_full_unstemmed | The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast |
| title_short | The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast |
| title_sort | use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast |
| topic | benign neoplasm of the breast partial mastectomy quality of life hydroxyethyldimethyldihydropyrimidine |
| url | https://modernonco.orscience.ru/1815-1434/article/viewFile/627193/142917 |
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