Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells
The recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is current...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-10-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396416304273 |
| _version_ | 1818152657077927936 |
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| author | Yannick Simonin Fabien Loustalot Caroline Desmetz Vincent Foulongne Orianne Constant Chantal Fournier-Wirth Fanny Leon Jean-Pierre Molès Aurélien Goubaud Jean-Marc Lemaitre Marianne Maquart Isabelle Leparc-Goffart Laurence Briant Nicolas Nagot Philippe Van de Perre Sara Salinas |
| author_facet | Yannick Simonin Fabien Loustalot Caroline Desmetz Vincent Foulongne Orianne Constant Chantal Fournier-Wirth Fanny Leon Jean-Pierre Molès Aurélien Goubaud Jean-Marc Lemaitre Marianne Maquart Isabelle Leparc-Goffart Laurence Briant Nicolas Nagot Philippe Van de Perre Sara Salinas |
| author_sort | Yannick Simonin |
| collection | DOAJ |
| description | The recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is currently found circulating in Africa. The original African strain was also suggested to be neurovirulent but its laboratory usage has been criticized due to its multiple passages. In this study, we compared the French Polynesian (Asian) ZIKV strain to an African strain isolated in Central African Republic and show a difference in infectivity and cellular response between both strains in human neural stem cells and astrocytes. Consistently, this African strain led to a higher infection rate and viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology and predict neurological impairment associated with African ZIKV. |
| first_indexed | 2024-12-11T13:58:12Z |
| format | Article |
| id | doaj.art-a1743ad88a0a4fa1836b38afa24ccd12 |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-11T13:58:12Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-a1743ad88a0a4fa1836b38afa24ccd122022-12-22T01:03:58ZengElsevierEBioMedicine2352-39642016-10-0112C16116910.1016/j.ebiom.2016.09.020Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural CellsYannick Simonin0Fabien Loustalot1Caroline Desmetz2Vincent Foulongne3Orianne Constant4Chantal Fournier-Wirth5Fanny Leon6Jean-Pierre Molès7Aurélien Goubaud8Jean-Marc Lemaitre9Marianne Maquart10Isabelle Leparc-Goffart11Laurence Briant12Nicolas Nagot13Philippe Van de Perre14Sara Salinas15UMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUniversité de Montpellier, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceInstitut de Médecine Régénératrice et Biothérapies, INSERM, U1183, Université de Montpellier, CHU Montpellier, Montpellier, FranceInstitut de Médecine Régénératrice et Biothérapies, INSERM, U1183, Université de Montpellier, CHU Montpellier, Montpellier, FranceCentre National de Référence des Arbovirus, Institut de Recherche Biomédicale des Armées, Marseille, FranceCentre National de Référence des Arbovirus, Institut de Recherche Biomédicale des Armées, Marseille, FranceCentre d'études d'agents Pathogènes et Biotechnologies pour la Santé, FRE3689, CNRS-Université de Montpellier, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceUMR 1058, INSERM, Université de Montpellier, Etablissement Français du Sang Pathogenesis and Control of Chronic Infections, Inserm, Montpellier, FranceThe recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is currently found circulating in Africa. The original African strain was also suggested to be neurovirulent but its laboratory usage has been criticized due to its multiple passages. In this study, we compared the French Polynesian (Asian) ZIKV strain to an African strain isolated in Central African Republic and show a difference in infectivity and cellular response between both strains in human neural stem cells and astrocytes. Consistently, this African strain led to a higher infection rate and viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology and predict neurological impairment associated with African ZIKV.http://www.sciencedirect.com/science/article/pii/S2352396416304273Zika virusLineagesNeural stem cellsAstrocytes |
| spellingShingle | Yannick Simonin Fabien Loustalot Caroline Desmetz Vincent Foulongne Orianne Constant Chantal Fournier-Wirth Fanny Leon Jean-Pierre Molès Aurélien Goubaud Jean-Marc Lemaitre Marianne Maquart Isabelle Leparc-Goffart Laurence Briant Nicolas Nagot Philippe Van de Perre Sara Salinas Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells EBioMedicine Zika virus Lineages Neural stem cells Astrocytes |
| title | Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells |
| title_full | Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells |
| title_fullStr | Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells |
| title_full_unstemmed | Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells |
| title_short | Zika Virus Strains Potentially Display Different Infectious Profiles in Human Neural Cells |
| title_sort | zika virus strains potentially display different infectious profiles in human neural cells |
| topic | Zika virus Lineages Neural stem cells Astrocytes |
| url | http://www.sciencedirect.com/science/article/pii/S2352396416304273 |
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