Acquisition Conditions for Lu-177 DOTATATE Imaging
We investigated imaging conditions for the distribution of lutetium oxodotreotide (Lu-177 DOTATATE) in the body during peptide receptor radionuclide therapy for neuroendocrine tumor (NET). We investigated imaging conditions using gamma rays emitted from the radionuclide. The gamma rays had energy pe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Radiation |
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| Online Access: | https://www.mdpi.com/2673-592X/4/1/2 |
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| author | Yuri Sagisaka Yasuyuki Takahashi Shota Hosokawa Niina Kanazawa Hiroki Yamamoto Go Takai Keiji Nagano |
| author_facet | Yuri Sagisaka Yasuyuki Takahashi Shota Hosokawa Niina Kanazawa Hiroki Yamamoto Go Takai Keiji Nagano |
| author_sort | Yuri Sagisaka |
| collection | DOAJ |
| description | We investigated imaging conditions for the distribution of lutetium oxodotreotide (Lu-177 DOTATATE) in the body during peptide receptor radionuclide therapy for neuroendocrine tumor (NET). We investigated imaging conditions using gamma rays emitted from the radionuclide. The gamma rays had energy peaks at 113 and 208 keV and characteristic X-rays at 56 keV. Image quality was compared by utilizing a combination of low–medium-energy general-purpose (LMEGP) and medium-energy general-purpose (MEGP) collimators. This study included the measurement of total spatial resolution (Full Width at Half Maximum) using a line source phantom. We compared the image quality of static images using a plane phantom and SPECT images using a cylindrical phantom. This comparison involved assessing recovery coefficient curves, count ratio, and %CV. Imaging evaluation was also performed on one NET patient. In phantom studies and the clinical study, comparing the combination of the three energy peaks (56 + 113 + 208 keV) using the LMEGP collimator and the conventional combination (113 + 208 keV) using the MEGP collimator revealed a count ratio of 1.9 times the maximum, stable %CV, and the best image quality. |
| first_indexed | 2024-04-24T17:53:02Z |
| format | Article |
| id | doaj.art-a1777f45a40643ce9f553bcce45cb25d |
| institution | Directory Open Access Journal |
| issn | 2673-592X |
| language | English |
| last_indexed | 2024-04-24T17:53:02Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Radiation |
| spelling | doaj.art-a1777f45a40643ce9f553bcce45cb25d2024-03-27T14:01:58ZengMDPI AGRadiation2673-592X2024-01-0141172510.3390/radiation4010002Acquisition Conditions for Lu-177 DOTATATE ImagingYuri Sagisaka0Yasuyuki Takahashi1Shota Hosokawa2Niina Kanazawa3Hiroki Yamamoto4Go Takai5Keiji Nagano6Department of Radiation Science, Graduate School of Health Sciences, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, JapanDepartment of Radiation Science, Graduate School of Health Sciences, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, JapanDepartment of Radiation Science, Graduate School of Health Sciences, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, JapanDepartment of Radiological Technology, Nihon University Itabashi Hospital, 30-1 Oyaguchi kami-cho Itabashi-ku, Tokyo 173-8610, JapanDepartment of Radiology, Division of Medical Technology, Hirosaki University Hospital, 53 Hon-cho, Hirosaki 036-8563, JapanDepartment of Radiological Technology, Division of Radiology, Kansai Electric Power Hospital, 2-1-7 Fukushima Fukushima-ku, Osaka 553-0003, JapanDivision of Radiation Management Center, Dokkyo Medical University Hospital, 880 Kitakobayashi, Mibumachi, Shimotsuga-gun, Tochigi 321-0293, JapanWe investigated imaging conditions for the distribution of lutetium oxodotreotide (Lu-177 DOTATATE) in the body during peptide receptor radionuclide therapy for neuroendocrine tumor (NET). We investigated imaging conditions using gamma rays emitted from the radionuclide. The gamma rays had energy peaks at 113 and 208 keV and characteristic X-rays at 56 keV. Image quality was compared by utilizing a combination of low–medium-energy general-purpose (LMEGP) and medium-energy general-purpose (MEGP) collimators. This study included the measurement of total spatial resolution (Full Width at Half Maximum) using a line source phantom. We compared the image quality of static images using a plane phantom and SPECT images using a cylindrical phantom. This comparison involved assessing recovery coefficient curves, count ratio, and %CV. Imaging evaluation was also performed on one NET patient. In phantom studies and the clinical study, comparing the combination of the three energy peaks (56 + 113 + 208 keV) using the LMEGP collimator and the conventional combination (113 + 208 keV) using the MEGP collimator revealed a count ratio of 1.9 times the maximum, stable %CV, and the best image quality.https://www.mdpi.com/2673-592X/4/1/2LMEGP collimatorthree peaksMEGP collimatortwo peaksLu-177 |
| spellingShingle | Yuri Sagisaka Yasuyuki Takahashi Shota Hosokawa Niina Kanazawa Hiroki Yamamoto Go Takai Keiji Nagano Acquisition Conditions for Lu-177 DOTATATE Imaging Radiation LMEGP collimator three peaks MEGP collimator two peaks Lu-177 |
| title | Acquisition Conditions for Lu-177 DOTATATE Imaging |
| title_full | Acquisition Conditions for Lu-177 DOTATATE Imaging |
| title_fullStr | Acquisition Conditions for Lu-177 DOTATATE Imaging |
| title_full_unstemmed | Acquisition Conditions for Lu-177 DOTATATE Imaging |
| title_short | Acquisition Conditions for Lu-177 DOTATATE Imaging |
| title_sort | acquisition conditions for lu 177 dotatate imaging |
| topic | LMEGP collimator three peaks MEGP collimator two peaks Lu-177 |
| url | https://www.mdpi.com/2673-592X/4/1/2 |
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