New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex

New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex

The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines <b>12</b> and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines <b>13</b> are reported here in six steps starting from various halogeno-quinazoline-2,4-(1<i>H</i>,3<i>H&...

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Bibliographic Details
Main Authors: Jean Guillon, Marc Le Borgne, Vittoria Milano, Aurore Guédin-Beaurepaire, Stéphane Moreau, Noël Pinaud, Luisa Ronga, Solène Savrimoutou, Sandra Albenque-Rubio, Mathieu Marchivie, Haouraa Kalout, Charley Walker, Louise Chevallier, Corinne Buré, Eric Largy, Valérie Gabelica, Jean-Louis Mergny, Virginie Baylot, Jacky Ferrer, Yamina Idrissi, Edith Chevret, David Cappellen, Vanessa Desplat, Zsuzsanna Schelz, István Zupkó
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceuticals
Subjects:
antiproliferative activities
2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline
2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline
G-quadruplex
G4 ligands
FRET-melting
Online Access:https://www.mdpi.com/1424-8247/17/1/30

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