Increased atherosclerosis in a mouse model of glycogen storage disease type 1a
Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
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| Series: | Molecular Genetics and Metabolism Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214426922000325 |
| _version_ | 1828766224358572032 |
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| author | Anouk M. La Rose Anouk G. Groenen Benedek Halmos Venetia Bazioti Martijn G.S. Rutten Kishore A. Krishnamurthy Mirjam H. Koster Niels J. Kloosterhuis Marieke Smit Rick Havinga Gilles Mithieux Fabienne Rajas Folkert Kuipers Maaike H. Oosterveer Marit Westerterp |
| author_facet | Anouk M. La Rose Anouk G. Groenen Benedek Halmos Venetia Bazioti Martijn G.S. Rutten Kishore A. Krishnamurthy Mirjam H. Koster Niels J. Kloosterhuis Marieke Smit Rick Havinga Gilles Mithieux Fabienne Rajas Folkert Kuipers Maaike H. Oosterveer Marit Westerterp |
| author_sort | Anouk M. La Rose |
| collection | DOAJ |
| description | Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort. |
| first_indexed | 2024-12-11T07:01:52Z |
| format | Article |
| id | doaj.art-a17931b37180404cb8818baa30ee324c |
| institution | Directory Open Access Journal |
| issn | 2214-4269 |
| language | English |
| last_indexed | 2024-12-11T07:01:52Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Genetics and Metabolism Reports |
| spelling | doaj.art-a17931b37180404cb8818baa30ee324c2022-12-22T01:16:37ZengElsevierMolecular Genetics and Metabolism Reports2214-42692022-06-0131100872Increased atherosclerosis in a mouse model of glycogen storage disease type 1aAnouk M. La Rose0Anouk G. Groenen1Benedek Halmos2Venetia Bazioti3Martijn G.S. Rutten4Kishore A. Krishnamurthy5Mirjam H. Koster6Niels J. Kloosterhuis7Marieke Smit8Rick Havinga9Gilles Mithieux10Fabienne Rajas11Folkert Kuipers12Maaike H. Oosterveer13Marit Westerterp14Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsUniversité Claude Bernard Lyon 1, Université de Lyon, INSERM UMR-S1213, Lyon, FranceUniversité Claude Bernard Lyon 1, Université de Lyon, INSERM UMR-S1213, Lyon, FranceDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsDepartment of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Corresponding author at: Department of Pediatrics, University Medical Center Groningen, ERIBA Building 3226 room 04.14, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands.Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited atherogenesis compared to age-and-gender matched controls. Employing a GSD Ia mouse model that resembles the severe hyperlipidemia in patients, we here found increased atherogenesis in GSD Ia. These data provide a rationale for investigating atherogenesis in GSD Ia in a larger patient cohort.http://www.sciencedirect.com/science/article/pii/S2214426922000325Glycogen storage disease type 1aAtherosclerosisHyperlipidemia |
| spellingShingle | Anouk M. La Rose Anouk G. Groenen Benedek Halmos Venetia Bazioti Martijn G.S. Rutten Kishore A. Krishnamurthy Mirjam H. Koster Niels J. Kloosterhuis Marieke Smit Rick Havinga Gilles Mithieux Fabienne Rajas Folkert Kuipers Maaike H. Oosterveer Marit Westerterp Increased atherosclerosis in a mouse model of glycogen storage disease type 1a Molecular Genetics and Metabolism Reports Glycogen storage disease type 1a Atherosclerosis Hyperlipidemia |
| title | Increased atherosclerosis in a mouse model of glycogen storage disease type 1a |
| title_full | Increased atherosclerosis in a mouse model of glycogen storage disease type 1a |
| title_fullStr | Increased atherosclerosis in a mouse model of glycogen storage disease type 1a |
| title_full_unstemmed | Increased atherosclerosis in a mouse model of glycogen storage disease type 1a |
| title_short | Increased atherosclerosis in a mouse model of glycogen storage disease type 1a |
| title_sort | increased atherosclerosis in a mouse model of glycogen storage disease type 1a |
| topic | Glycogen storage disease type 1a Atherosclerosis Hyperlipidemia |
| url | http://www.sciencedirect.com/science/article/pii/S2214426922000325 |
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