Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects
The human nasal microbiome can be a reservoir for several pathogens, including <i>Staphylococcus aureus</i>. However, certain harmless nasal commensals can interfere with pathogen colonisation, an ability that could be exploited to prevent infection. Although attractive as a prophylactic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/6/489 |
| _version_ | 1827658541013401600 |
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| author | Lea A. Adolf Simon Heilbronner |
| author_facet | Lea A. Adolf Simon Heilbronner |
| author_sort | Lea A. Adolf |
| collection | DOAJ |
| description | The human nasal microbiome can be a reservoir for several pathogens, including <i>Staphylococcus aureus</i>. However, certain harmless nasal commensals can interfere with pathogen colonisation, an ability that could be exploited to prevent infection. Although attractive as a prophylactic strategy, manipulation of nasal microbiomes to prevent pathogen colonisation requires a better understanding of the molecular mechanisms of interaction that occur between nasal commensals as well as between commensals and pathogens. Our knowledge concerning the mechanisms of pathogen exclusion and how stable community structures are established is patchy and incomplete. Nutrients are scarce in nasal cavities, which makes competitive or mutualistic traits in nutrient acquisition very likely. In this review, we focus on nutritional interactions that have been shown to or might occur between nasal microbiome members. We summarise concepts of nutrient release from complex host molecules and host cells as well as of intracommunity exchange of energy-rich fermentation products and siderophores. Finally, we discuss the potential of genome-based metabolic models to predict complex nutritional interactions between members of the nasal microbiome. |
| first_indexed | 2024-03-09T23:05:10Z |
| format | Article |
| id | doaj.art-a1794598902047a181b7790f29e41251 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:05:10Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-a1794598902047a181b7790f29e412512023-11-23T17:55:31ZengMDPI AGMetabolites2218-19892022-05-0112648910.3390/metabo12060489Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future ProspectsLea A. Adolf0Simon Heilbronner1Interfaculty Institute for Microbiology and Infection Medicine, Institute for Medical Microbiology and Hygiene, UKT Tübingen, 72076 Tübingen, GermanyInterfaculty Institute for Microbiology and Infection Medicine, Institute for Medical Microbiology and Hygiene, UKT Tübingen, 72076 Tübingen, GermanyThe human nasal microbiome can be a reservoir for several pathogens, including <i>Staphylococcus aureus</i>. However, certain harmless nasal commensals can interfere with pathogen colonisation, an ability that could be exploited to prevent infection. Although attractive as a prophylactic strategy, manipulation of nasal microbiomes to prevent pathogen colonisation requires a better understanding of the molecular mechanisms of interaction that occur between nasal commensals as well as between commensals and pathogens. Our knowledge concerning the mechanisms of pathogen exclusion and how stable community structures are established is patchy and incomplete. Nutrients are scarce in nasal cavities, which makes competitive or mutualistic traits in nutrient acquisition very likely. In this review, we focus on nutritional interactions that have been shown to or might occur between nasal microbiome members. We summarise concepts of nutrient release from complex host molecules and host cells as well as of intracommunity exchange of energy-rich fermentation products and siderophores. Finally, we discuss the potential of genome-based metabolic models to predict complex nutritional interactions between members of the nasal microbiome.https://www.mdpi.com/2218-1989/12/6/489nasal microbiome<i>Staphylococcus aureus</i>bacterial interactionnutritional interaction |
| spellingShingle | Lea A. Adolf Simon Heilbronner Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects Metabolites nasal microbiome <i>Staphylococcus aureus</i> bacterial interaction nutritional interaction |
| title | Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects |
| title_full | Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects |
| title_fullStr | Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects |
| title_full_unstemmed | Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects |
| title_short | Nutritional Interactions between Bacterial Species Colonising the Human Nasal Cavity: Current Knowledge and Future Prospects |
| title_sort | nutritional interactions between bacterial species colonising the human nasal cavity current knowledge and future prospects |
| topic | nasal microbiome <i>Staphylococcus aureus</i> bacterial interaction nutritional interaction |
| url | https://www.mdpi.com/2218-1989/12/6/489 |
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