Calcium oxalate crystal-induced secretome derived from proximal tubular cells, not that from distal tubular cells, induces renal fibroblast activation

Calcium oxalate crystal-induced secretome derived from proximal tubular cells, not that from distal tubular cells, induces renal fibroblast activation

Abstract Background Kidney stone disease (KSD) is commonly accompanied with renal fibrosis, characterized by accumulation and reorganization of extracellular matrix (ECM). During fibrogenesis, resident renal fibroblasts are activated to become myofibroblasts that actively produce ECM. However, such...

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Bibliographic Details
Main Authors: Chadanat Noonin, Tanakorn Itsaranawet, Visith Thongboonkerd
Format: Article
Language:English
Published: BMC 2023-04-01
Series:European Journal of Medical Research
Subjects:
COM crystal
Fibrogenesis
Kidney stone
Myofibroblast
Renal fibrosis
Renal interstitium
Online Access:https://doi.org/10.1186/s40001-023-01109-3

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