Association Study Identifying a New Susceptibility Gene (AUTS2) for Schizophrenia
Schizophrenia (SCZ) is a severe and debilitating mental disorder, and the specific genetic factors that underlie the risk for SCZ remain elusive. The autism susceptibility candidate 2 (AUTS2) gene has been reported to be associated with autism, suicide, alcohol consumption, and heroin dependence. We...
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| Format: | Article |
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MDPI AG
2014-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/15/11/19406 |
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| author | Bao Zhang Yue-Hong Xu Shu-Guang Wei Hong-Bo Zhang Dong-Ke Fu Zu-Fei Feng Fang-Lin Guan Yong-Sheng Zhu Sheng-Bin Li |
| author_facet | Bao Zhang Yue-Hong Xu Shu-Guang Wei Hong-Bo Zhang Dong-Ke Fu Zu-Fei Feng Fang-Lin Guan Yong-Sheng Zhu Sheng-Bin Li |
| author_sort | Bao Zhang |
| collection | DOAJ |
| description | Schizophrenia (SCZ) is a severe and debilitating mental disorder, and the specific genetic factors that underlie the risk for SCZ remain elusive. The autism susceptibility candidate 2 (AUTS2) gene has been reported to be associated with autism, suicide, alcohol consumption, and heroin dependence. We hypothesized that AUTS2 might be associated with SCZ. In the present study, three polymorphisms (rs6943555, rs7459368, and rs9886351) in the AUTS2 gene were genotyped in 410 patients with SCZ and 435 controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and forced PCR-RFLP methods. We detected an association between SCZ and the rs6943555 genotype distribution (odds ratio (OR) = 1.363, 95% confidence interval (CI): 0.848–2.191, p = 0.001). The association remained significant after adjusting for gender, and a significant effect (p = 0.001) was observed among the females. In the present study, rs6943555 was determined to be associated with female SCZ. Our results confirm previous reports which have suggested that rs6943555 might elucidate the pathogenesis of schizophrenia and play an important role in its etiology. |
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| format | Article |
| id | doaj.art-a17b374de0834a9fa11b69f2a6db415a |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T15:13:23Z |
| publishDate | 2014-10-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a17b374de0834a9fa11b69f2a6db415a2022-12-22T03:27:42ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-10-011511194061941610.3390/ijms151119406ijms151119406Association Study Identifying a New Susceptibility Gene (AUTS2) for SchizophreniaBao Zhang0Yue-Hong Xu1Shu-Guang Wei2Hong-Bo Zhang3Dong-Ke Fu4Zu-Fei Feng5Fang-Lin Guan6Yong-Sheng Zhu7Sheng-Bin Li8College of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaCollege of Forensic Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, ChinaSchizophrenia (SCZ) is a severe and debilitating mental disorder, and the specific genetic factors that underlie the risk for SCZ remain elusive. The autism susceptibility candidate 2 (AUTS2) gene has been reported to be associated with autism, suicide, alcohol consumption, and heroin dependence. We hypothesized that AUTS2 might be associated with SCZ. In the present study, three polymorphisms (rs6943555, rs7459368, and rs9886351) in the AUTS2 gene were genotyped in 410 patients with SCZ and 435 controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and forced PCR-RFLP methods. We detected an association between SCZ and the rs6943555 genotype distribution (odds ratio (OR) = 1.363, 95% confidence interval (CI): 0.848–2.191, p = 0.001). The association remained significant after adjusting for gender, and a significant effect (p = 0.001) was observed among the females. In the present study, rs6943555 was determined to be associated with female SCZ. Our results confirm previous reports which have suggested that rs6943555 might elucidate the pathogenesis of schizophrenia and play an important role in its etiology.http://www.mdpi.com/1422-0067/15/11/19406AUTS2 geneSNPschizophreniaassociation study |
| spellingShingle | Bao Zhang Yue-Hong Xu Shu-Guang Wei Hong-Bo Zhang Dong-Ke Fu Zu-Fei Feng Fang-Lin Guan Yong-Sheng Zhu Sheng-Bin Li Association Study Identifying a New Susceptibility Gene (AUTS2) for Schizophrenia International Journal of Molecular Sciences AUTS2 gene SNP schizophrenia association study |
| title | Association Study Identifying a New Susceptibility Gene (AUTS2) for Schizophrenia |
| title_full | Association Study Identifying a New Susceptibility Gene (AUTS2) for Schizophrenia |
| title_fullStr | Association Study Identifying a New Susceptibility Gene (AUTS2) for Schizophrenia |
| title_full_unstemmed | Association Study Identifying a New Susceptibility Gene (AUTS2) for Schizophrenia |
| title_short | Association Study Identifying a New Susceptibility Gene (AUTS2) for Schizophrenia |
| title_sort | association study identifying a new susceptibility gene auts2 for schizophrenia |
| topic | AUTS2 gene SNP schizophrenia association study |
| url | http://www.mdpi.com/1422-0067/15/11/19406 |
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