Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming some of the major health problems in well-developed countries, together with the increasing prevalence of obesity, metabolic syndrome, and all of their systemic complications. As the future prognoses are...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/8/9/298 |
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| author | Karolina Grąt Michał Grąt Olgierd Rowiński |
| author_facet | Karolina Grąt Michał Grąt Olgierd Rowiński |
| author_sort | Karolina Grąt |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming some of the major health problems in well-developed countries, together with the increasing prevalence of obesity, metabolic syndrome, and all of their systemic complications. As the future prognoses are even more disturbing and point toward further increase in population affected with NAFLD/NASH, there is an urgent need for widely available and reliable diagnostic methods. Consensus on a non-invasive, accurate diagnostic modality for the use in ongoing clinical trials is also required, particularly considering a current lack of any registered drug for the treatment of NAFLD/NASH. The aim of this narrative review was to present current information on methods used to assess liver steatosis and fibrosis. There are several imaging modalities for the assessment of hepatic steatosis ranging from simple density analysis by computed tomography or conventional B-mode ultrasound to magnetic resonance spectroscopy (MRS), magnetic resonance imaging proton density fat fraction (MRI-PDFF) or controlled attenuation parameter (CAP). Fibrosis stage can be assessed by magnetic resonance elastography (MRE) or different ultrasound-based techniques: transient elastography (TE), shear-wave elastography (SWE) and acoustic radiation force impulse (ARFI). Although all of these methods have been validated against liver biopsy as the reference standard and provided good accuracy, the MRS and MRI-PDFF currently outperform other methods in terms of diagnosis of steatosis, and MRE in terms of evaluation of fibrosis. |
| first_indexed | 2024-03-10T17:01:07Z |
| format | Article |
| id | doaj.art-a17cc4f6552b4f8589beca19493329d5 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T17:01:07Z |
| publishDate | 2020-08-01 |
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| series | Biomedicines |
| spelling | doaj.art-a17cc4f6552b4f8589beca19493329d52023-11-20T10:58:59ZengMDPI AGBiomedicines2227-90592020-08-018929810.3390/biomedicines8090298Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver DiseaseKarolina Grąt0Michał Grąt1Olgierd Rowiński2Second Department of Clinical Radiology, Medical University of Warsaw, 02-097 Warsaw, PolandDepartment of General, Transplant and Liver Surgery, Medical University of Warsaw, 02-097 Warsaw, PolandSecond Department of Clinical Radiology, Medical University of Warsaw, 02-097 Warsaw, PolandNon-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming some of the major health problems in well-developed countries, together with the increasing prevalence of obesity, metabolic syndrome, and all of their systemic complications. As the future prognoses are even more disturbing and point toward further increase in population affected with NAFLD/NASH, there is an urgent need for widely available and reliable diagnostic methods. Consensus on a non-invasive, accurate diagnostic modality for the use in ongoing clinical trials is also required, particularly considering a current lack of any registered drug for the treatment of NAFLD/NASH. The aim of this narrative review was to present current information on methods used to assess liver steatosis and fibrosis. There are several imaging modalities for the assessment of hepatic steatosis ranging from simple density analysis by computed tomography or conventional B-mode ultrasound to magnetic resonance spectroscopy (MRS), magnetic resonance imaging proton density fat fraction (MRI-PDFF) or controlled attenuation parameter (CAP). Fibrosis stage can be assessed by magnetic resonance elastography (MRE) or different ultrasound-based techniques: transient elastography (TE), shear-wave elastography (SWE) and acoustic radiation force impulse (ARFI). Although all of these methods have been validated against liver biopsy as the reference standard and provided good accuracy, the MRS and MRI-PDFF currently outperform other methods in terms of diagnosis of steatosis, and MRE in terms of evaluation of fibrosis.https://www.mdpi.com/2227-9059/8/9/298NASHNAFLDliver stiffnessliver steatosiscontrolled attenuation parametertransient elastography |
| spellingShingle | Karolina Grąt Michał Grąt Olgierd Rowiński Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease Biomedicines NASH NAFLD liver stiffness liver steatosis controlled attenuation parameter transient elastography |
| title | Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease |
| title_full | Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease |
| title_fullStr | Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease |
| title_full_unstemmed | Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease |
| title_short | Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease |
| title_sort | usefulness of different imaging modalities in evaluation of patients with non alcoholic fatty liver disease |
| topic | NASH NAFLD liver stiffness liver steatosis controlled attenuation parameter transient elastography |
| url | https://www.mdpi.com/2227-9059/8/9/298 |
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