Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation
Depression is a common, often recurrent disorder that causes substantial disease burden worldwide, and this is especially true for women following the pubertal transition. According to the Social Signal Transduction Theory of Depression, stressors involving social stress and rejection, which frequen...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266635462100137X |
| _version_ | 1819292929291714560 |
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| author | Stassja Sichko Theresa Q. Bui Meghan Vinograd Grant S. Shields Krishanu Saha Suzanne Devkota Hector A. Olvera-Alvarez Judith E. Carroll Steven W. Cole Michael R. Irwin George M. Slavich |
| author_facet | Stassja Sichko Theresa Q. Bui Meghan Vinograd Grant S. Shields Krishanu Saha Suzanne Devkota Hector A. Olvera-Alvarez Judith E. Carroll Steven W. Cole Michael R. Irwin George M. Slavich |
| author_sort | Stassja Sichko |
| collection | DOAJ |
| description | Depression is a common, often recurrent disorder that causes substantial disease burden worldwide, and this is especially true for women following the pubertal transition. According to the Social Signal Transduction Theory of Depression, stressors involving social stress and rejection, which frequently precipitate major depressive episodes, induce depressive symptoms in vulnerable individuals in part by altering the activity and connectivity of stress-related neural pathways, and by upregulating components of the immune system involved in inflammation. To test this theory, we recruited adolescent females at high and low risk for depression and assessed their psychological, neural, inflammatory, and genomic responses to a brief (10 minute) social stress task, in addition to trait psychological and microbial factors affecting these responses. We then followed these adolescents longitudinally to investigate how their multi-level stress responses at baseline were related to their biological aging at baseline, and psychosocial and clinical functioning over one year. In this protocol paper, we describe the theoretical motivations for conducting this study as well as the sample, study design, procedures, and measures. Ultimately, our aim is to elucidate how social adversity influences the brain and immune system to cause depression, one of the most common and costly of all disorders. |
| first_indexed | 2024-12-24T04:02:20Z |
| format | Article |
| id | doaj.art-a17d072544fd4299ba604526bb1a0bcd |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-12-24T04:02:20Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-a17d072544fd4299ba604526bb1a0bcd2022-12-21T17:16:17ZengElsevierBrain, Behavior, & Immunity - Health2666-35462021-11-0117100334Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigationStassja Sichko0Theresa Q. Bui1Meghan Vinograd2Grant S. Shields3Krishanu Saha4Suzanne Devkota5Hector A. Olvera-Alvarez6Judith E. Carroll7Steven W. Cole8Michael R. Irwin9George M. Slavich10Department of Psychology, University of California, Los Angeles, CA, USATulane University School of Medicine, New Orleans, LA, USACenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, and Department of Psychiatry, University of California, San Diego, CA, USADepartment of Psychological Science, University of Arkansas, Fayetteville, AR, USAWisconsin Institute for Discovery and Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USADepartment of Medicine, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, and David Geffen School of Medicine at UCLA, Los Angeles, CA, USASchool of Nursing, Oregon Health & Science University, Portland, OR, USACousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USACousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USADepartment of Psychology, University of California, Los Angeles, CA, USA; Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USACousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA; Corresponding author. Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, UCLA Medical Plaza 300, Room 3156, Los Angeles, CA, 90095-7076, USA.Depression is a common, often recurrent disorder that causes substantial disease burden worldwide, and this is especially true for women following the pubertal transition. According to the Social Signal Transduction Theory of Depression, stressors involving social stress and rejection, which frequently precipitate major depressive episodes, induce depressive symptoms in vulnerable individuals in part by altering the activity and connectivity of stress-related neural pathways, and by upregulating components of the immune system involved in inflammation. To test this theory, we recruited adolescent females at high and low risk for depression and assessed their psychological, neural, inflammatory, and genomic responses to a brief (10 minute) social stress task, in addition to trait psychological and microbial factors affecting these responses. We then followed these adolescents longitudinally to investigate how their multi-level stress responses at baseline were related to their biological aging at baseline, and psychosocial and clinical functioning over one year. In this protocol paper, we describe the theoretical motivations for conducting this study as well as the sample, study design, procedures, and measures. Ultimately, our aim is to elucidate how social adversity influences the brain and immune system to cause depression, one of the most common and costly of all disorders.http://www.sciencedirect.com/science/article/pii/S266635462100137XAdolescentDepressionSocial rejectionNeuralfMRINeuroimaging |
| spellingShingle | Stassja Sichko Theresa Q. Bui Meghan Vinograd Grant S. Shields Krishanu Saha Suzanne Devkota Hector A. Olvera-Alvarez Judith E. Carroll Steven W. Cole Michael R. Irwin George M. Slavich Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation Brain, Behavior, & Immunity - Health Adolescent Depression Social rejection Neural fMRI Neuroimaging |
| title | Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation |
| title_full | Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation |
| title_fullStr | Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation |
| title_full_unstemmed | Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation |
| title_short | Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation |
| title_sort | psychobiology of stress and adolescent depression psy sad study protocol overview for an fmri based multi method investigation |
| topic | Adolescent Depression Social rejection Neural fMRI Neuroimaging |
| url | http://www.sciencedirect.com/science/article/pii/S266635462100137X |
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