Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation
<p>Abstract</p> <p>Background</p> <p>Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal...
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| Format: | Article |
| Language: | English |
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BMC
2011-07-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://www.biomedcentral.com/1471-230X/11/82 |
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| author | Frediani Simone Federici Tatiana Marcheggiano Adriana D'Alfonso Ylenia Lastrucci Ginevra Nardo Giovanni Lucarelli Sandra Frediani Tullio Cucchiara Salvatore |
| author_facet | Frediani Simone Federici Tatiana Marcheggiano Adriana D'Alfonso Ylenia Lastrucci Ginevra Nardo Giovanni Lucarelli Sandra Frediani Tullio Cucchiara Salvatore |
| author_sort | Frediani Simone |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim of this study was to assess whether the atopy patch test (APT) could be helpful to identify this subgroup of patients requiring to discontinue breast-feeding due to polisensitization. Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula</p> <p>Methods</p> <p>We have prospectively enrolled 14 exclusively breast-fed infants with APC refractory to maternal allergen avoidance. The diagnosis was confirmed by endoscopy with biopsies. Skin prick tests and serum specific IgE for common foods, together with APTs for common foods plus breast milk, were performed. After a 1 month therapy of an AAF all patients underwent a follow-up rectosigmoidoscopy.</p> <p>Results</p> <p>Prick tests and serum specific IgE were negative. APTs were positive in 100% infants, with a multiple positivity in 50%. Sensitization was found for breast milk in 100%, cow's milk (50%), soy (28%), egg (21%), rice (14%), wheat (7%). Follow-up rectosigmoidoscopy confirmed the remission of APC in all infants.</p> <p>Conclusions</p> <p>These data suggest that APT might become a useful tool to identify subgroups of infants with multiple gastrointestinal food allergy involving a delayed immunogenic mechanism, with the aim to avoid unnecessary maternal dietary restrictions before discontinuing breast-feeding.</p> |
| first_indexed | 2024-12-22T20:56:31Z |
| format | Article |
| id | doaj.art-a17dec735eb94aa18c08eac07622ff25 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-22T20:56:31Z |
| publishDate | 2011-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-a17dec735eb94aa18c08eac07622ff252022-12-21T18:12:56ZengBMCBMC Gastroenterology1471-230X2011-07-011118210.1186/1471-230X-11-82Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observationFrediani SimoneFederici TatianaMarcheggiano AdrianaD'Alfonso YleniaLastrucci GinevraNardo GiovanniLucarelli SandraFrediani TullioCucchiara Salvatore<p>Abstract</p> <p>Background</p> <p>Allergic proctocolitis (APC) in exclusively breast-fed infants is caused by food proteins, deriving from maternal diet, transferred through lactation. In most cases a maternal cow milk-free diet leads to a prompt resolution of rectal bleeding, while in some patients a multiple food allergy can occur. The aim of this study was to assess whether the atopy patch test (APT) could be helpful to identify this subgroup of patients requiring to discontinue breast-feeding due to polisensitization. Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula</p> <p>Methods</p> <p>We have prospectively enrolled 14 exclusively breast-fed infants with APC refractory to maternal allergen avoidance. The diagnosis was confirmed by endoscopy with biopsies. Skin prick tests and serum specific IgE for common foods, together with APTs for common foods plus breast milk, were performed. After a 1 month therapy of an AAF all patients underwent a follow-up rectosigmoidoscopy.</p> <p>Results</p> <p>Prick tests and serum specific IgE were negative. APTs were positive in 100% infants, with a multiple positivity in 50%. Sensitization was found for breast milk in 100%, cow's milk (50%), soy (28%), egg (21%), rice (14%), wheat (7%). Follow-up rectosigmoidoscopy confirmed the remission of APC in all infants.</p> <p>Conclusions</p> <p>These data suggest that APT might become a useful tool to identify subgroups of infants with multiple gastrointestinal food allergy involving a delayed immunogenic mechanism, with the aim to avoid unnecessary maternal dietary restrictions before discontinuing breast-feeding.</p>http://www.biomedcentral.com/1471-230X/11/82allergic proctocolitisfood allergybreast feedingpatch test |
| spellingShingle | Frediani Simone Federici Tatiana Marcheggiano Adriana D'Alfonso Ylenia Lastrucci Ginevra Nardo Giovanni Lucarelli Sandra Frediani Tullio Cucchiara Salvatore Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation BMC Gastroenterology allergic proctocolitis food allergy breast feeding patch test |
| title | Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation |
| title_full | Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation |
| title_fullStr | Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation |
| title_full_unstemmed | Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation |
| title_short | Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation |
| title_sort | allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast fed infants a clinical observation |
| topic | allergic proctocolitis food allergy breast feeding patch test |
| url | http://www.biomedcentral.com/1471-230X/11/82 |
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