| Summary: | Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare inflammatory disease of unknown origin, which may be asymptomatic or produce symptoms like pruritus, pain, or spontaneous bleeding, and which has no sex predilection. The treatment options are cryosurgery, pulsed dye laser, topical tacrolimus, surgery, curettage, and oral retinoids. Below is a report of a clinical case of angiolymphoid hyperplasia with eosinophilia in the oral cavity, as well as the treatment performed. This was a female patient who attended a stomatology and oral surgery clinic due to a localized lesion at the level of the vestibule between dental organs 11 and 12. Clinically, there was a nodular lesion of about 1 cm in diameter, located at the level of attached gingiva; it was asymptomatic on palpation and of unknown etiology. Angiolymphoid hyperplasia is an unusual pathology in the oral cavity; its etiology is unknown, and a definitive diagnosis should be made through histopathological examination and clinical signs.
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