Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy
<i>Background and Objectives</i>: The diagnosis and treatment of pituitary adenomas with cavernous sinus invasion pose significant challenges for clinicians. The objective of this study is to investigate the expression profile and prognostic value of HSPB1 (heat shock protein beta-1) in...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/59/5/885 |
| _version_ | 1797599210034429952 |
|---|---|
| author | Sida Zhao Bin Li Yiyuan Chen Chuzhong Li Yazhuo Zhang |
| author_facet | Sida Zhao Bin Li Yiyuan Chen Chuzhong Li Yazhuo Zhang |
| author_sort | Sida Zhao |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The diagnosis and treatment of pituitary adenomas with cavernous sinus invasion pose significant challenges for clinicians. The objective of this study is to investigate the expression profile and prognostic value of HSPB1 (heat shock protein beta-1) in pituitary adenomas with invasive and non-invasive features. Additionally, we aim to explore the potential relationship between HSPB1 expression and immunological functions in pituitary adenoma. <i>Materials and Methods</i>: A total of 159 pituitary adenoma specimens (73 invasive tumours and 86 non-invasive tumours) underwent whole-transcriptome sequencing. Differentially expressed genes and pathways in invasive and non-invasive tumours were analysed. HSPB1 was subjected to adequate bioinformatics analysis using various databases such as TIMER, Xiantao and TISIDB. We investigated the correlation between HSPB1 expression and immune infiltration in cancers and predicted the target drug of HSPB1 using the TISIDB database. <i>Results</i>: HSPB1 expression was upregulated in invasive pituitary adenomas and affected immune cell infiltration. HSPB1 was significantly highly expressed in most tumours compared to normal tissues. High expression of HSPB1 was significantly associated with poorer overall survival. HSPB1 was involved in the regulation of the immune system in most cancers. The drugs DB11638, DB06094 and DB12695 could act as inhibitors of HSPB1. <i>Conclusions</i>: HSPB1 may serve as an important marker for invasive pituitary adenomas and promote tumour progression by modulating the immune system. Inhibitors of HSPB1 expression are currently available, making it a potential target for therapy in invasive pituitary adenoma. |
| first_indexed | 2024-03-11T03:31:29Z |
| format | Article |
| id | doaj.art-a181a07a7fad4424a0ec7983ea945ff4 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:29Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-a181a07a7fad4424a0ec7983ea945ff42023-11-18T02:21:41ZengMDPI AGMedicina1010-660X1648-91442023-05-0159588510.3390/medicina59050885Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for TherapySida Zhao0Bin Li1Yiyuan Chen2Chuzhong Li3Yazhuo Zhang4Department of Cell and Biology, Beijing Neurosurgical Institute, Capital Medical University, No. 119, South Fourth Ring West Road, Fengtai District, Beijing 100070, ChinaDepartment of Cell and Biology, Beijing Neurosurgical Institute, Capital Medical University, No. 119, South Fourth Ring West Road, Fengtai District, Beijing 100070, ChinaDepartment of Cell and Biology, Beijing Neurosurgical Institute, Capital Medical University, No. 119, South Fourth Ring West Road, Fengtai District, Beijing 100070, ChinaNeurosurgical Department, Beijing Tiantan Hospital, Capital Medical University, No. 119, South Fourth Ring West Road, Fengtai District, Beijing 100070, ChinaDepartment of Cell and Biology, Beijing Neurosurgical Institute, Capital Medical University, No. 119, South Fourth Ring West Road, Fengtai District, Beijing 100070, China<i>Background and Objectives</i>: The diagnosis and treatment of pituitary adenomas with cavernous sinus invasion pose significant challenges for clinicians. The objective of this study is to investigate the expression profile and prognostic value of HSPB1 (heat shock protein beta-1) in pituitary adenomas with invasive and non-invasive features. Additionally, we aim to explore the potential relationship between HSPB1 expression and immunological functions in pituitary adenoma. <i>Materials and Methods</i>: A total of 159 pituitary adenoma specimens (73 invasive tumours and 86 non-invasive tumours) underwent whole-transcriptome sequencing. Differentially expressed genes and pathways in invasive and non-invasive tumours were analysed. HSPB1 was subjected to adequate bioinformatics analysis using various databases such as TIMER, Xiantao and TISIDB. We investigated the correlation between HSPB1 expression and immune infiltration in cancers and predicted the target drug of HSPB1 using the TISIDB database. <i>Results</i>: HSPB1 expression was upregulated in invasive pituitary adenomas and affected immune cell infiltration. HSPB1 was significantly highly expressed in most tumours compared to normal tissues. High expression of HSPB1 was significantly associated with poorer overall survival. HSPB1 was involved in the regulation of the immune system in most cancers. The drugs DB11638, DB06094 and DB12695 could act as inhibitors of HSPB1. <i>Conclusions</i>: HSPB1 may serve as an important marker for invasive pituitary adenomas and promote tumour progression by modulating the immune system. Inhibitors of HSPB1 expression are currently available, making it a potential target for therapy in invasive pituitary adenoma.https://www.mdpi.com/1648-9144/59/5/885HSPB1pituitary adenomainvasioncavernous sinusbiomarker |
| spellingShingle | Sida Zhao Bin Li Yiyuan Chen Chuzhong Li Yazhuo Zhang Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy Medicina HSPB1 pituitary adenoma invasion cavernous sinus biomarker |
| title | Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy |
| title_full | Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy |
| title_fullStr | Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy |
| title_full_unstemmed | Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy |
| title_short | Analysis of the Prognostic and Immunological Role of HSPB1 in Pituitary Adenoma: A Potential Target for Therapy |
| title_sort | analysis of the prognostic and immunological role of hspb1 in pituitary adenoma a potential target for therapy |
| topic | HSPB1 pituitary adenoma invasion cavernous sinus biomarker |
| url | https://www.mdpi.com/1648-9144/59/5/885 |
| work_keys_str_mv | AT sidazhao analysisoftheprognosticandimmunologicalroleofhspb1inpituitaryadenomaapotentialtargetfortherapy AT binli analysisoftheprognosticandimmunologicalroleofhspb1inpituitaryadenomaapotentialtargetfortherapy AT yiyuanchen analysisoftheprognosticandimmunologicalroleofhspb1inpituitaryadenomaapotentialtargetfortherapy AT chuzhongli analysisoftheprognosticandimmunologicalroleofhspb1inpituitaryadenomaapotentialtargetfortherapy AT yazhuozhang analysisoftheprognosticandimmunologicalroleofhspb1inpituitaryadenomaapotentialtargetfortherapy |