Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis
Abstract Introduction To investigate the associations of alopecia areata (AA) with serum vitamin D and calcium levels. Methods A systematic review of all relevant articles published up to February 2020 in PubMed, Embase, and Cochrane Library databases was conducted. Primary endpoints were serum 25-h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2020-08-01
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| Series: | Dermatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s13555-020-00433-4 |
| _version_ | 1818444022309453824 |
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| author | Yi Liu Jing Li Guirong Liang Chaojiang Cheng Yue Li Xinfeng Wu |
| author_facet | Yi Liu Jing Li Guirong Liang Chaojiang Cheng Yue Li Xinfeng Wu |
| author_sort | Yi Liu |
| collection | DOAJ |
| description | Abstract Introduction To investigate the associations of alopecia areata (AA) with serum vitamin D and calcium levels. Methods A systematic review of all relevant articles published up to February 2020 in PubMed, Embase, and Cochrane Library databases was conducted. Primary endpoints were serum 25-hydroxyvitamin D [25(OH)D] levels and vitamin D deficiency, and the secondary endpoint was serum calcium level. Odds ratio (OR) and standardized mean difference (SMD) with 95% CI across studies were analyzed. Results Data on 1585 patients with AA and 1114 controls from 16 case–control studies and three cross-sectional studies were included in this meta-analysis. A pooled meta-analysis was conducted using the random-effects model because of inter-study heterogeneity (vitamin D level, I 2 = 87.90%; vitamin D deficiency, I 2 = 81.10%; serum calcium level, I 2 = 83.80%). A combined analysis revealed that patients with AA had significantly lower mean serum 25(OH)D level compared with control (WMD − 9.08, 95% CI − 11.65, − 6.50, p < 0.001), and were more likely to have vitamin D deficiency (OR 4.14, 95% CI 2.34, 7.35, p < 0.001). However, the pooled analysis revealed that patients with AA did not have significantly lower serum calcium levels compared with control (WMD − 0.17, 95% CI − 0.40, 0.06, p = 0.143). Subgroup analysis suggested that matched control, mean age, and country might contribute to the heterogeneity of serum vitamin D level, while study design, matched control, and country might contribute to the heterogeneity of vitamin D deficiency. Conclusion Deficiency of serum 25(OH)D level, rather than calcium level, was present in patients with AA. Screening for vitamin D deficiency and vitamin D supplementation may be beneficial in the treatment of patients with AA. |
| first_indexed | 2024-12-14T19:09:19Z |
| format | Article |
| id | doaj.art-a1845d40049a4605b1adb4b333c1c481 |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-12-14T19:09:19Z |
| publishDate | 2020-08-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-a1845d40049a4605b1adb4b333c1c4812022-12-21T22:50:47ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722020-08-0110596798310.1007/s13555-020-00433-4Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysisYi Liu0Jing Li1Guirong Liang2Chaojiang Cheng3Yue Li4Xinfeng Wu5Department of Plastic and Reconstructive Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Plastic and Reconstructive Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Plastic and Reconstructive Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Plastic and Reconstructive Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Plastic and Reconstructive Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical CollegeDepartment of Plastic and Reconstructive Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical CollegeAbstract Introduction To investigate the associations of alopecia areata (AA) with serum vitamin D and calcium levels. Methods A systematic review of all relevant articles published up to February 2020 in PubMed, Embase, and Cochrane Library databases was conducted. Primary endpoints were serum 25-hydroxyvitamin D [25(OH)D] levels and vitamin D deficiency, and the secondary endpoint was serum calcium level. Odds ratio (OR) and standardized mean difference (SMD) with 95% CI across studies were analyzed. Results Data on 1585 patients with AA and 1114 controls from 16 case–control studies and three cross-sectional studies were included in this meta-analysis. A pooled meta-analysis was conducted using the random-effects model because of inter-study heterogeneity (vitamin D level, I 2 = 87.90%; vitamin D deficiency, I 2 = 81.10%; serum calcium level, I 2 = 83.80%). A combined analysis revealed that patients with AA had significantly lower mean serum 25(OH)D level compared with control (WMD − 9.08, 95% CI − 11.65, − 6.50, p < 0.001), and were more likely to have vitamin D deficiency (OR 4.14, 95% CI 2.34, 7.35, p < 0.001). However, the pooled analysis revealed that patients with AA did not have significantly lower serum calcium levels compared with control (WMD − 0.17, 95% CI − 0.40, 0.06, p = 0.143). Subgroup analysis suggested that matched control, mean age, and country might contribute to the heterogeneity of serum vitamin D level, while study design, matched control, and country might contribute to the heterogeneity of vitamin D deficiency. Conclusion Deficiency of serum 25(OH)D level, rather than calcium level, was present in patients with AA. Screening for vitamin D deficiency and vitamin D supplementation may be beneficial in the treatment of patients with AA.https://doi.org/10.1007/s13555-020-00433-4Alopecia areataAreataCalciumVitamin D1,25-Dihydroxyvitamin D25-Hydroxyvitamin D |
| spellingShingle | Yi Liu Jing Li Guirong Liang Chaojiang Cheng Yue Li Xinfeng Wu Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis Dermatology and Therapy Alopecia areata Areata Calcium Vitamin D 1,25-Dihydroxyvitamin D 25-Hydroxyvitamin D |
| title | Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis |
| title_full | Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis |
| title_fullStr | Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis |
| title_short | Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis |
| title_sort | association of alopecia areata with vitamin d and calcium levels a systematic review and meta analysis |
| topic | Alopecia areata Areata Calcium Vitamin D 1,25-Dihydroxyvitamin D 25-Hydroxyvitamin D |
| url | https://doi.org/10.1007/s13555-020-00433-4 |
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