Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands.
Falling asleep at the wrong time can place an individual at risk of immediate physical harm. However, not sleeping degrades cognition and adaptive behavior. To understand how animals match sleep need with environmental demands, we used live-brain imaging to examine the physiological response propert...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-09-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3001797 |
| _version_ | 1811175414667673600 |
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| author | Stephane Dissel Markus K Klose Bruno van Swinderen Lijuan Cao Melanie Ford Erica M Periandri Joseph D Jones Zhaoyi Li Paul J Shaw |
| author_facet | Stephane Dissel Markus K Klose Bruno van Swinderen Lijuan Cao Melanie Ford Erica M Periandri Joseph D Jones Zhaoyi Li Paul J Shaw |
| author_sort | Stephane Dissel |
| collection | DOAJ |
| description | Falling asleep at the wrong time can place an individual at risk of immediate physical harm. However, not sleeping degrades cognition and adaptive behavior. To understand how animals match sleep need with environmental demands, we used live-brain imaging to examine the physiological response properties of the dorsal fan-shaped body (dFB) following interventions that modify sleep (sleep deprivation, starvation, time-restricted feeding, memory consolidation) in Drosophila. We report that dFB neurons change their physiological response-properties to dopamine (DA) and allatostatin-A (AstA) in response to different types of waking. That is, dFB neurons are not simply passive components of a hard-wired circuit. Rather, the dFB neurons intrinsically regulate their response to the activity from upstream circuits. Finally, we show that the dFB appears to contain a memory trace of prior exposure to metabolic challenges induced by starvation or time-restricted feeding. Together, these data highlight that the sleep homeostat is plastic and suggests an underlying mechanism. |
| first_indexed | 2024-04-10T19:35:47Z |
| format | Article |
| id | doaj.art-a185768b26564f07a9095e92797a31a8 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-04-10T19:35:47Z |
| publishDate | 2022-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-a185768b26564f07a9095e92797a31a82023-01-30T05:30:21ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852022-09-01209e300179710.1371/journal.pbio.3001797Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands.Stephane DisselMarkus K KloseBruno van SwinderenLijuan CaoMelanie FordErica M PeriandriJoseph D JonesZhaoyi LiPaul J ShawFalling asleep at the wrong time can place an individual at risk of immediate physical harm. However, not sleeping degrades cognition and adaptive behavior. To understand how animals match sleep need with environmental demands, we used live-brain imaging to examine the physiological response properties of the dorsal fan-shaped body (dFB) following interventions that modify sleep (sleep deprivation, starvation, time-restricted feeding, memory consolidation) in Drosophila. We report that dFB neurons change their physiological response-properties to dopamine (DA) and allatostatin-A (AstA) in response to different types of waking. That is, dFB neurons are not simply passive components of a hard-wired circuit. Rather, the dFB neurons intrinsically regulate their response to the activity from upstream circuits. Finally, we show that the dFB appears to contain a memory trace of prior exposure to metabolic challenges induced by starvation or time-restricted feeding. Together, these data highlight that the sleep homeostat is plastic and suggests an underlying mechanism.https://doi.org/10.1371/journal.pbio.3001797 |
| spellingShingle | Stephane Dissel Markus K Klose Bruno van Swinderen Lijuan Cao Melanie Ford Erica M Periandri Joseph D Jones Zhaoyi Li Paul J Shaw Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. PLoS Biology |
| title | Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. |
| title_full | Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. |
| title_fullStr | Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. |
| title_full_unstemmed | Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. |
| title_short | Sleep-promoting neurons remodel their response properties to calibrate sleep drive with environmental demands. |
| title_sort | sleep promoting neurons remodel their response properties to calibrate sleep drive with environmental demands |
| url | https://doi.org/10.1371/journal.pbio.3001797 |
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