Proteomic Studies of Blood and Vascular Wall in Atherosclerosis
The review is devoted to the analysis of literature data related to the role of proteomic studies in the study of atherosclerotic cardiovascular diseases. Diagnosis of patients with atherosclerotic plaques before clinical manifestations is an arduous task. The review presents the results of research...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/24/13267 |
| _version_ | 1797503887798697984 |
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| author | Ekaterina Mikhailovna Stakhneva Evgeniia Vitalievna Striukova Yulia Igorevna Ragino |
| author_facet | Ekaterina Mikhailovna Stakhneva Evgeniia Vitalievna Striukova Yulia Igorevna Ragino |
| author_sort | Ekaterina Mikhailovna Stakhneva |
| collection | DOAJ |
| description | The review is devoted to the analysis of literature data related to the role of proteomic studies in the study of atherosclerotic cardiovascular diseases. Diagnosis of patients with atherosclerotic plaques before clinical manifestations is an arduous task. The review presents the results of research on the new proteomic potential biomarkers of coronary heart disease, coronary atherosclerosis, acute coronary syndrome, myocardial infarction, carotid artery atherosclerosis. Also, the analysis of literature data on proteomic studies of the vascular wall was carried out. To assess the involvement of proteins in the pathological process of atherosclerosis, it is important to investigate the specific relationships between proteins in the arteries, expression and concentration of proteins. The development of proteomic technologies has made it possible to analyse the number of proteins associated with the development of the disease. Analysis of the proteomic profile of the vascular wall in atherosclerosis can help to detect possible diagnostically significant protein structures or potential biomarkers of the disease and develop novel approaches to the diagnosis of atherosclerosis and its complications. |
| first_indexed | 2024-03-10T03:56:48Z |
| format | Article |
| id | doaj.art-a18663ac3e9d480b9a2e1d35a70f0b27 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:56:48Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a18663ac3e9d480b9a2e1d35a70f0b272023-11-23T08:43:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122241326710.3390/ijms222413267Proteomic Studies of Blood and Vascular Wall in AtherosclerosisEkaterina Mikhailovna Stakhneva0Evgeniia Vitalievna Striukova1Yulia Igorevna Ragino2The Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, St. B. Bogatkova 175/1, 630089 Novosibirsk, RussiaThe Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, St. B. Bogatkova 175/1, 630089 Novosibirsk, RussiaThe Institute of Internal and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, St. B. Bogatkova 175/1, 630089 Novosibirsk, RussiaThe review is devoted to the analysis of literature data related to the role of proteomic studies in the study of atherosclerotic cardiovascular diseases. Diagnosis of patients with atherosclerotic plaques before clinical manifestations is an arduous task. The review presents the results of research on the new proteomic potential biomarkers of coronary heart disease, coronary atherosclerosis, acute coronary syndrome, myocardial infarction, carotid artery atherosclerosis. Also, the analysis of literature data on proteomic studies of the vascular wall was carried out. To assess the involvement of proteins in the pathological process of atherosclerosis, it is important to investigate the specific relationships between proteins in the arteries, expression and concentration of proteins. The development of proteomic technologies has made it possible to analyse the number of proteins associated with the development of the disease. Analysis of the proteomic profile of the vascular wall in atherosclerosis can help to detect possible diagnostically significant protein structures or potential biomarkers of the disease and develop novel approaches to the diagnosis of atherosclerosis and its complications.https://www.mdpi.com/1422-0067/22/24/13267proteomicsatherosclerosisbiomarkersmass spectrometry |
| spellingShingle | Ekaterina Mikhailovna Stakhneva Evgeniia Vitalievna Striukova Yulia Igorevna Ragino Proteomic Studies of Blood and Vascular Wall in Atherosclerosis International Journal of Molecular Sciences proteomics atherosclerosis biomarkers mass spectrometry |
| title | Proteomic Studies of Blood and Vascular Wall in Atherosclerosis |
| title_full | Proteomic Studies of Blood and Vascular Wall in Atherosclerosis |
| title_fullStr | Proteomic Studies of Blood and Vascular Wall in Atherosclerosis |
| title_full_unstemmed | Proteomic Studies of Blood and Vascular Wall in Atherosclerosis |
| title_short | Proteomic Studies of Blood and Vascular Wall in Atherosclerosis |
| title_sort | proteomic studies of blood and vascular wall in atherosclerosis |
| topic | proteomics atherosclerosis biomarkers mass spectrometry |
| url | https://www.mdpi.com/1422-0067/22/24/13267 |
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