The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes
Abstract Background The ALDH2 rs671 genetic polymorphism has been linked with cardiovascular diseases (CVDs), but comprehensive epidemiological studies are lacking. An observational, retrospective big data study was carried out to evaluate the associations between this polymorphism and clustering ca...
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| Format: | Article |
| Language: | English |
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BMC
2020-12-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-020-01787-5 |
| _version_ | 1819072674280767488 |
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| author | Danchen Wang Yutong Zou Songlin Yu Songbai Lin Honglei Li Yicong Yin Ling Qiu Tengda Xu Jie Wu |
| author_facet | Danchen Wang Yutong Zou Songlin Yu Songbai Lin Honglei Li Yicong Yin Ling Qiu Tengda Xu Jie Wu |
| author_sort | Danchen Wang |
| collection | DOAJ |
| description | Abstract Background The ALDH2 rs671 genetic polymorphism has been linked with cardiovascular diseases (CVDs), but comprehensive epidemiological studies are lacking. An observational, retrospective big data study was carried out to evaluate the associations between this polymorphism and clustering cardiovascular risk factors (CRFs) in a Chinese population. Methods A total of 13,101 individuals (8431 males and 4670 females) were enrolled. Genetic polymorphism was assessed using gene mutation detection kits, coupled with an automatic fluorescent analyzer. Other data were obtained from the records of the Department of Health Care at Peking Union Medical College Hospital. Results Comparing the concentrations of common biochemical analytes, including BMI, SBP, DBP, ALT, AST, γ-GT, TBil, Cr, Glu, TC, TG, and HDL-C among individuals with the GG, GA, and AA genotypes of ALDH2 rs671, we found significant differences in males (all p < 0.001), but not in females. For males, the frequencies of hypertension, diabetes, and obesity were significantly higher for GG than for GA or AA (all p < 0.05). However, there was no significant difference for dyslipidemia, and no significant associations were observed for all frequencies in females. The prevalence of individuals with 1–4 CRFs was significantly higher among GG males than those carrying GA or AA, and fewer GG males had non-CRFs (all p < 0.05). Conclusion Polymorphisms of ALDH2 rs671 are associated with clustering CRFs, especially hypertension and diabetes in males, but not in females. These associations are likely mediated by alcohol intake, which is also associated with this gene. |
| first_indexed | 2024-12-21T17:41:29Z |
| format | Article |
| id | doaj.art-a1866ec4a4e741b2b91e0a867e82dce9 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-21T17:41:29Z |
| publishDate | 2020-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-a1866ec4a4e741b2b91e0a867e82dce92022-12-21T18:55:37ZengBMCBMC Cardiovascular Disorders1471-22612020-12-012011710.1186/s12872-020-01787-5The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexesDanchen Wang0Yutong Zou1Songlin Yu2Songbai Lin3Honglei Li4Yicong Yin5Ling Qiu6Tengda Xu7Jie Wu8Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Health Care, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Health Care, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesAbstract Background The ALDH2 rs671 genetic polymorphism has been linked with cardiovascular diseases (CVDs), but comprehensive epidemiological studies are lacking. An observational, retrospective big data study was carried out to evaluate the associations between this polymorphism and clustering cardiovascular risk factors (CRFs) in a Chinese population. Methods A total of 13,101 individuals (8431 males and 4670 females) were enrolled. Genetic polymorphism was assessed using gene mutation detection kits, coupled with an automatic fluorescent analyzer. Other data were obtained from the records of the Department of Health Care at Peking Union Medical College Hospital. Results Comparing the concentrations of common biochemical analytes, including BMI, SBP, DBP, ALT, AST, γ-GT, TBil, Cr, Glu, TC, TG, and HDL-C among individuals with the GG, GA, and AA genotypes of ALDH2 rs671, we found significant differences in males (all p < 0.001), but not in females. For males, the frequencies of hypertension, diabetes, and obesity were significantly higher for GG than for GA or AA (all p < 0.05). However, there was no significant difference for dyslipidemia, and no significant associations were observed for all frequencies in females. The prevalence of individuals with 1–4 CRFs was significantly higher among GG males than those carrying GA or AA, and fewer GG males had non-CRFs (all p < 0.05). Conclusion Polymorphisms of ALDH2 rs671 are associated with clustering CRFs, especially hypertension and diabetes in males, but not in females. These associations are likely mediated by alcohol intake, which is also associated with this gene.https://doi.org/10.1186/s12872-020-01787-5ALDH2rs671Cardiovascular diseaseCardiovascular risk factor |
| spellingShingle | Danchen Wang Yutong Zou Songlin Yu Songbai Lin Honglei Li Yicong Yin Ling Qiu Tengda Xu Jie Wu The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes BMC Cardiovascular Disorders ALDH2 rs671 Cardiovascular disease Cardiovascular risk factor |
| title | The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes |
| title_full | The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes |
| title_fullStr | The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes |
| title_full_unstemmed | The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes |
| title_short | The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes |
| title_sort | effect of aldh2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of chinese population associations differ between the sexes |
| topic | ALDH2 rs671 Cardiovascular disease Cardiovascular risk factor |
| url | https://doi.org/10.1186/s12872-020-01787-5 |
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