Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018
Using national registries, we investigated the epidemiological trends of hepatobiliary carcinomas in Austria between 2010 and 2018 and compared them to those reported for the periods of 1990–1999 and 2000–2009. In total, 12,577 patients diagnosed with hepatocellular carcinoma (<i>n</i> =...
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MDPI AG
2022-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/13/3093 |
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| author | Florian Hucke Matthias Pinter Miriam Hucke Simona Bota Dajana Bolf Monika Hackl Markus Peck-Radosavljevic |
| author_facet | Florian Hucke Matthias Pinter Miriam Hucke Simona Bota Dajana Bolf Monika Hackl Markus Peck-Radosavljevic |
| author_sort | Florian Hucke |
| collection | DOAJ |
| description | Using national registries, we investigated the epidemiological trends of hepatobiliary carcinomas in Austria between 2010 and 2018 and compared them to those reported for the periods of 1990–1999 and 2000–2009. In total, 12,577 patients diagnosed with hepatocellular carcinoma (<i>n</i> = 7146), intrahepatic cholangiocarcinoma (<i>n</i> = 1858), extrahepatic cholangiocarcinoma (<i>n</i> = 1649), gallbladder carcinoma (<i>n</i> = 1365), and ampullary carcinoma (<i>n</i> = 559), between 2010 and 2018, were included. The median overall survival of all patients was 9.0 months. The best median overall survival was observed in patients with ampullary carcinoma (28.5 months) and the worst median overall survival was observed in patients with intrahepatic carcinoma (5.6 months). The overall survival significantly improved in all entities over the period 2010–2018 as compared with over the periods of 2000–2009 and 1990–1999. Age-adjusted incidence and mortality rates remained stable for most entities in both, men and women; only in gallbladder carcinoma, the incidence and mortality rates significantly decreased in women, whereas, in men, the incidence rates remained stable and mortality rates showed a decreasing trend. We showed that age-adjusted incidence and mortality rates were stable in most entities, except in gallbladder carcinoma. The overall survival improved in almost all entities as compared with those during 1990–2009. |
| first_indexed | 2024-03-09T22:04:42Z |
| format | Article |
| id | doaj.art-a186db36b52a4658a3a79cddfe90bcad |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:04:42Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a186db36b52a4658a3a79cddfe90bcad2023-11-23T19:44:13ZengMDPI AGCancers2072-66942022-06-011413309310.3390/cancers14133093Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018Florian Hucke0Matthias Pinter1Miriam Hucke2Simona Bota3Dajana Bolf4Monika Hackl5Markus Peck-Radosavljevic6Internal Medicine and Gastroenterology (IMuG), Hepatology, Endocrinology, Rheumatology and Nephrology Including Centralized Emergency Department (ZAE), Klinikum Klagenfurt am Wörthersee, 9020 Klagenfurt, AustriaDivision of Gastroenterology and Hepatology, Department of Internal Medicine III, Liver Cancer (HCC) Study Group Vienna, Medical University of Vienna, 1090 Vienna, AustriaInternal Medicine and Gastroenterology (IMuG), Hepatology, Endocrinology, Rheumatology and Nephrology Including Centralized Emergency Department (ZAE), Klinikum Klagenfurt am Wörthersee, 9020 Klagenfurt, AustriaInternal Medicine and Gastroenterology (IMuG), Hepatology, Endocrinology, Rheumatology and Nephrology Including Centralized Emergency Department (ZAE), Klinikum Klagenfurt am Wörthersee, 9020 Klagenfurt, AustriaInternal Medicine and Gastroenterology (IMuG), Hepatology, Endocrinology, Rheumatology and Nephrology Including Centralized Emergency Department (ZAE), Klinikum Klagenfurt am Wörthersee, 9020 Klagenfurt, AustriaAustrian National Cancer Registry, Statistics Austria, 1110 Vienna, AustriaInternal Medicine and Gastroenterology (IMuG), Hepatology, Endocrinology, Rheumatology and Nephrology Including Centralized Emergency Department (ZAE), Klinikum Klagenfurt am Wörthersee, 9020 Klagenfurt, AustriaUsing national registries, we investigated the epidemiological trends of hepatobiliary carcinomas in Austria between 2010 and 2018 and compared them to those reported for the periods of 1990–1999 and 2000–2009. In total, 12,577 patients diagnosed with hepatocellular carcinoma (<i>n</i> = 7146), intrahepatic cholangiocarcinoma (<i>n</i> = 1858), extrahepatic cholangiocarcinoma (<i>n</i> = 1649), gallbladder carcinoma (<i>n</i> = 1365), and ampullary carcinoma (<i>n</i> = 559), between 2010 and 2018, were included. The median overall survival of all patients was 9.0 months. The best median overall survival was observed in patients with ampullary carcinoma (28.5 months) and the worst median overall survival was observed in patients with intrahepatic carcinoma (5.6 months). The overall survival significantly improved in all entities over the period 2010–2018 as compared with over the periods of 2000–2009 and 1990–1999. Age-adjusted incidence and mortality rates remained stable for most entities in both, men and women; only in gallbladder carcinoma, the incidence and mortality rates significantly decreased in women, whereas, in men, the incidence rates remained stable and mortality rates showed a decreasing trend. We showed that age-adjusted incidence and mortality rates were stable in most entities, except in gallbladder carcinoma. The overall survival improved in almost all entities as compared with those during 1990–2009.https://www.mdpi.com/2072-6694/14/13/3093hepatocellular carcinomabiliary tract cancerscholangiocarcinomagallbladder carcinomaampullary carcinomaincidence |
| spellingShingle | Florian Hucke Matthias Pinter Miriam Hucke Simona Bota Dajana Bolf Monika Hackl Markus Peck-Radosavljevic Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018 Cancers hepatocellular carcinoma biliary tract cancers cholangiocarcinoma gallbladder carcinoma ampullary carcinoma incidence |
| title | Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018 |
| title_full | Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018 |
| title_fullStr | Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018 |
| title_full_unstemmed | Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018 |
| title_short | Changing Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010–2018 |
| title_sort | changing epidemiological trends of hepatobiliary carcinomas in austria 2010 2018 |
| topic | hepatocellular carcinoma biliary tract cancers cholangiocarcinoma gallbladder carcinoma ampullary carcinoma incidence |
| url | https://www.mdpi.com/2072-6694/14/13/3093 |
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