Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence

Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence

The functionality of DNA biomacromolecules has been widely excavated, as therapeutic drugs, carriers, and functionalized modification derivatives. In this study, we developed a series of DNA tetrahedron nanocages (Td), via synchronous conjugating different numbers of i-(X) and therapeutic siRNA on f...

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Bibliographic Details
Main Authors: Xiu Han, Xiang Xu, Ziheng Wu, Zhenghong Wu, Xiaole Qi
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
i-motif
siRNA
Gene delivery
DNA tetrahedron
Endosomal escape
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000472

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