Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease
Objective: PGC-1α is already known as a significant regulator of mitochondrial biogenesis, oxidative phosphorylation and fatty acid metabolism. Our study focuses on the role of PGC1α in morbid obesity, in five different tissues, collected from 50 severely obese patients during planned bariatric surg...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
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| Series: | Hellenic Journal of Cardiology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1109966618302525 |
| _version_ | 1818923092403027968 |
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| author | Konstantinos Balampanis Athina Chasapi Eleni Kourea Anna Tanoglidi Erifili Hatziagelaki Vaia Lambadiari George Dimitriadis George I. Lambrou Fotios Kalfarentzos Maria Melachrinou Georgia Sotiropoulou-Bonikou |
| author_facet | Konstantinos Balampanis Athina Chasapi Eleni Kourea Anna Tanoglidi Erifili Hatziagelaki Vaia Lambadiari George Dimitriadis George I. Lambrou Fotios Kalfarentzos Maria Melachrinou Georgia Sotiropoulou-Bonikou |
| author_sort | Konstantinos Balampanis |
| collection | DOAJ |
| description | Objective: PGC-1α is already known as a significant regulator of mitochondrial biogenesis, oxidative phosphorylation and fatty acid metabolism. Our study focuses on the role of PGC1α in morbid obesity, in five different tissues, collected from 50 severely obese patients during planned bariatric surgery. Methods: The investigated tissues included subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), skeletal muscle (SM), extramyocellular adipose tissue (EMAT) and liver. PGC1α expression was investigated with immunohistochemistry and evaluated with microscopy. Results: Our findings highlighted significant positive inter-tissue correlations regarding PGC-1α expression between several tissue pairs (VAT-SAT, VAT-SM, VAT-EMAT, SAT-SM, SAT-EMAT, SM-EMAT). Moreover, we found significant negative correlations between PGC1α expression in VAT with CD68 expression in skeletal muscle and EMAT, implying a possible protective role of PGC1α against obesity-induced inflammation. Conclusion: Unmasking the inter-tissue communication networks regarding PGC-1α expression in morbid obesity, will give more insight into its significant role in obesity-induced diseases. PGC1α could potentially represent a future preventive and therapeutic target against obesity-induced disease, probably through enhancing mitochondrial biogenesis and metabolism. Keywords: Obesity, diabetes, metabolic syndrome, peroxisome proliferator-activated receptor gamma (PPAR-γ) coactivator 1α, PGC-1α |
| first_indexed | 2024-12-20T02:03:56Z |
| format | Article |
| id | doaj.art-a1882c40bc3442fb82b1389cde58d37a |
| institution | Directory Open Access Journal |
| issn | 1109-9666 |
| language | English |
| last_indexed | 2024-12-20T02:03:56Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hellenic Journal of Cardiology |
| spelling | doaj.art-a1882c40bc3442fb82b1389cde58d37a2022-12-21T19:57:15ZengElsevierHellenic Journal of Cardiology1109-96662019-09-01605282293Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced diseaseKonstantinos Balampanis0Athina Chasapi1Eleni Kourea2Anna Tanoglidi3Erifili Hatziagelaki4Vaia Lambadiari5George Dimitriadis6George I. Lambrou7Fotios Kalfarentzos8Maria Melachrinou9Georgia Sotiropoulou-Bonikou10Department of Pathology, Medical School, University of Patras, 26500 Patras, Greece; Second Department of Internal Medicine, Research Unit and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Rimini 1, Haidari, 12462 Athens, GreeceDepartment of Pathology, Medical School, University of Patras, 26500 Patras, Greece; Corresponding author. Athina Chasapi, Department of Pathology, Medical School, University of Patras, 26500 Patras, Greece.Department of Pathology, Medical School, University of Patras, 26500 Patras, GreeceDepartment of Clinical Pathology, Akademiska University, Uppsala, SwedenSecond Department of Internal Medicine, Research Unit and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Rimini 1, Haidari, 12462 Athens, GreeceSecond Department of Internal Medicine, Research Unit and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Rimini 1, Haidari, 12462 Athens, GreeceSecond Department of Internal Medicine, Research Unit and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Rimini 1, Haidari, 12462 Athens, GreeceFirst Department of Pediatrics, Choremeio Research Laboratory, National and Kapodistrian University of Athens, Medical School, Thivon & Levadeias 8, Goudi, 11527 Athens, GreeceDepartment of Surgery, Medical School, University of Patras, 26500 Patras, GreeceDepartment of Pathology, Medical School, University of Patras, 26500 Patras, GreeceDepartment of Anatomy and Histology-Embryology, Medical School, University of Patras, 26500 Patras, GreeceObjective: PGC-1α is already known as a significant regulator of mitochondrial biogenesis, oxidative phosphorylation and fatty acid metabolism. Our study focuses on the role of PGC1α in morbid obesity, in five different tissues, collected from 50 severely obese patients during planned bariatric surgery. Methods: The investigated tissues included subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), skeletal muscle (SM), extramyocellular adipose tissue (EMAT) and liver. PGC1α expression was investigated with immunohistochemistry and evaluated with microscopy. Results: Our findings highlighted significant positive inter-tissue correlations regarding PGC-1α expression between several tissue pairs (VAT-SAT, VAT-SM, VAT-EMAT, SAT-SM, SAT-EMAT, SM-EMAT). Moreover, we found significant negative correlations between PGC1α expression in VAT with CD68 expression in skeletal muscle and EMAT, implying a possible protective role of PGC1α against obesity-induced inflammation. Conclusion: Unmasking the inter-tissue communication networks regarding PGC-1α expression in morbid obesity, will give more insight into its significant role in obesity-induced diseases. PGC1α could potentially represent a future preventive and therapeutic target against obesity-induced disease, probably through enhancing mitochondrial biogenesis and metabolism. Keywords: Obesity, diabetes, metabolic syndrome, peroxisome proliferator-activated receptor gamma (PPAR-γ) coactivator 1α, PGC-1αhttp://www.sciencedirect.com/science/article/pii/S1109966618302525 |
| spellingShingle | Konstantinos Balampanis Athina Chasapi Eleni Kourea Anna Tanoglidi Erifili Hatziagelaki Vaia Lambadiari George Dimitriadis George I. Lambrou Fotios Kalfarentzos Maria Melachrinou Georgia Sotiropoulou-Bonikou Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease Hellenic Journal of Cardiology |
| title | Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease |
| title_full | Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease |
| title_fullStr | Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease |
| title_full_unstemmed | Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease |
| title_short | Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease |
| title_sort | inter tissue expression patterns of the key metabolic biomarker pgc 1α in severely obese individuals implication in obesity induced disease |
| url | http://www.sciencedirect.com/science/article/pii/S1109966618302525 |
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