Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headache
Introduction: Post-traumatic headaches (PTH) are common following mild traumatic brain injury (mTBI). There is evidence of altered central pain processing in adult PTH; however, little is known about how children with PTH process pain. The anterior cingulate cortex (ACC) plays a critical role in des...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-04-01
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| Series: | Cephalalgia Reports |
| Online Access: | https://doi.org/10.1177/25158163211009477 |
| _version_ | 1819327193186041856 |
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| author | Zahra Ofoghi Christiane S Rohr Deborah Dewey Signe Bray Keith Owen Yeates Melanie Noel Karen M Barlow |
| author_facet | Zahra Ofoghi Christiane S Rohr Deborah Dewey Signe Bray Keith Owen Yeates Melanie Noel Karen M Barlow |
| author_sort | Zahra Ofoghi |
| collection | DOAJ |
| description | Introduction: Post-traumatic headaches (PTH) are common following mild traumatic brain injury (mTBI). There is evidence of altered central pain processing in adult PTH; however, little is known about how children with PTH process pain. The anterior cingulate cortex (ACC) plays a critical role in descending central pain modulation. In this study, we explored whether the functional connectivity (FC) of the ACC is altered in children with PTH. Methods: In this case-control study, we investigated resting-state FC of 5 ACC seeds (caudal, dorsal, rostral, perigenual, and subgenual) in children with PTH ( n = 73) and without PTH ( n = 29) following mTBI, and healthy controls ( n = 27). Post-concussion symptoms were assessed using the Post-Concussion Symptom Inventory and the Child Health Questionnaire. Resting-state functional Magnetic Resonance Imaging (fMRI) data were used to generate maps of ACC FC. Group-level comparisons were performed within a target mask comprised of pain-related regions using FSL Randomise. Results: We found decreased FC between the right perigenual ACC and the left cerebellum, and increased FC between the right subgenual ACC and the left dorsolateral prefrontal cortex in children with PTH compared to healthy controls. The ACC FC in children without PTH following mTBI did not differ from the group with PTH or healthy controls. FC between rostral and perigenual ACC seeds and the cerebellum was increased in children with PTH with pre-injury headaches compared to those with PTH without pre-injury headaches. There was a positive relationship between PTH severity and rostral ACC FC with the bilateral thalamus, right hippocampus and periaqueductal gray. Conclusions: Central pain processing is altered in children with PTH. Pre-existing headaches help to drive this process. Trial registration: The PlayGame Trial was registered in ClinicalTrials.gov database ( ClinicalTrials.gov Identifier: NCT01874847). |
| first_indexed | 2024-12-24T13:06:57Z |
| format | Article |
| id | doaj.art-a1888d873580444b80339cc55a50f1c4 |
| institution | Directory Open Access Journal |
| issn | 2515-8163 |
| language | English |
| last_indexed | 2024-12-24T13:06:57Z |
| publishDate | 2021-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cephalalgia Reports |
| spelling | doaj.art-a1888d873580444b80339cc55a50f1c42022-12-21T16:53:59ZengSAGE PublishingCephalalgia Reports2515-81632021-04-01410.1177/25158163211009477Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headacheZahra Ofoghi0Christiane S Rohr1Deborah Dewey2Signe Bray3Keith Owen Yeates4Melanie Noel5Karen M Barlow6 Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Child and Adolescent Imaging Research Program, University of Calgary, Calgary, Alberta, Canada Owerko Centre at the Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada Child and Adolescent Imaging Research Program, University of Calgary, Calgary, Alberta, Canada Department of Psychology, University of Calgary, Calgary, Alberta, Canada Department of Psychology, University of Calgary, Calgary, Alberta, Canada Paediatric Neurology Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, AustraliaIntroduction: Post-traumatic headaches (PTH) are common following mild traumatic brain injury (mTBI). There is evidence of altered central pain processing in adult PTH; however, little is known about how children with PTH process pain. The anterior cingulate cortex (ACC) plays a critical role in descending central pain modulation. In this study, we explored whether the functional connectivity (FC) of the ACC is altered in children with PTH. Methods: In this case-control study, we investigated resting-state FC of 5 ACC seeds (caudal, dorsal, rostral, perigenual, and subgenual) in children with PTH ( n = 73) and without PTH ( n = 29) following mTBI, and healthy controls ( n = 27). Post-concussion symptoms were assessed using the Post-Concussion Symptom Inventory and the Child Health Questionnaire. Resting-state functional Magnetic Resonance Imaging (fMRI) data were used to generate maps of ACC FC. Group-level comparisons were performed within a target mask comprised of pain-related regions using FSL Randomise. Results: We found decreased FC between the right perigenual ACC and the left cerebellum, and increased FC between the right subgenual ACC and the left dorsolateral prefrontal cortex in children with PTH compared to healthy controls. The ACC FC in children without PTH following mTBI did not differ from the group with PTH or healthy controls. FC between rostral and perigenual ACC seeds and the cerebellum was increased in children with PTH with pre-injury headaches compared to those with PTH without pre-injury headaches. There was a positive relationship between PTH severity and rostral ACC FC with the bilateral thalamus, right hippocampus and periaqueductal gray. Conclusions: Central pain processing is altered in children with PTH. Pre-existing headaches help to drive this process. Trial registration: The PlayGame Trial was registered in ClinicalTrials.gov database ( ClinicalTrials.gov Identifier: NCT01874847).https://doi.org/10.1177/25158163211009477 |
| spellingShingle | Zahra Ofoghi Christiane S Rohr Deborah Dewey Signe Bray Keith Owen Yeates Melanie Noel Karen M Barlow Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headache Cephalalgia Reports |
| title | Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headache |
| title_full | Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headache |
| title_fullStr | Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headache |
| title_full_unstemmed | Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headache |
| title_short | Functional connectivity of the anterior cingulate cortex with pain-related regions in children with post-traumatic headache |
| title_sort | functional connectivity of the anterior cingulate cortex with pain related regions in children with post traumatic headache |
| url | https://doi.org/10.1177/25158163211009477 |
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