Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study
Abstract Background To evaluate changes in the vessel density (VD) of the optic nerve head (ONH) microvasculature in thyroid eye disease (TED) using optical coherence tomography angiography (OCTA). This study aimed to applicate the OCTA as a noninvasive modality in screening TED patients to assess s...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Thyroid Research |
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| Online Access: | https://doi.org/10.1186/s13044-022-00134-4 |
| _version_ | 1811208816984850432 |
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| author | Aliakbar Sabermoghaddam Nasser Shoeibi Hamid Jafarzadeh Elham Bakhtiari Zeinab Salahi Talieh Saeidi Rezvani Hamid Reza Heidarzadeh Mojtaba Abrishami |
| author_facet | Aliakbar Sabermoghaddam Nasser Shoeibi Hamid Jafarzadeh Elham Bakhtiari Zeinab Salahi Talieh Saeidi Rezvani Hamid Reza Heidarzadeh Mojtaba Abrishami |
| author_sort | Aliakbar Sabermoghaddam |
| collection | DOAJ |
| description | Abstract Background To evaluate changes in the vessel density (VD) of the optic nerve head (ONH) microvasculature in thyroid eye disease (TED) using optical coherence tomography angiography (OCTA). This study aimed to applicate the OCTA as a noninvasive modality in screening TED patients to assess sub-clinical changes. Methods In a cross-sectional study, the control group patients were healthy individuals with no ocular abnormalities and were euthyroid. All patients with TED had clinical features of the disease. We divided them into two groups using the clinical activity score (CAS). Patients with CAS scores 0–2 were categorized as group A, and scores three or more as group B. All vessels (AV) and small vessels (SV) VD inside disc and radial peripapillary capillary network were measured using the ONH-OCTA. Results We evaluated 29 patients with TED and 28 healthy controls. The mean whole image AV VD (mean ± SD: 56.33 ± 2.56, p-value = 0.17) and the mean whole image SV VD (mean ± SD: 49.94 ± 2.56, p-value = 0.16) in the TED group had no statically significant difference compared with the control group (AV mean ± SD: 57.20 ± 20.22, SV mean ± SD: 50.84 ± 2.23). We found a non-significant decrease in AV and SV radial peripapillary capillary VD in the TED group. There was a significant decrease in the mean whole image AV VD (mean ± SD: 54.83 ± 3.07, p-value = 0.005) and the mean whole image SV VD (mean ± SD: 48.60 ± 3.18, p-value = 0.013) in CAS group B compared to group A (AV mean ± SD: 57.45 ± 1.33, SV mean ± SD: 50.95 ± 1.37). Conclusion Our study showed non-significant ONH vascular alterations in patients with TED, including reduced VD of ONH in the radial peripapillary capillary. Patients with higher CAS scores had a more noticeable decrease in ONH microvasculature. |
| first_indexed | 2024-04-12T04:27:58Z |
| format | Article |
| id | doaj.art-a1888dfa6f4a40f28e22761931237223 |
| institution | Directory Open Access Journal |
| issn | 1756-6614 |
| language | English |
| last_indexed | 2024-04-12T04:27:58Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Thyroid Research |
| spelling | doaj.art-a1888dfa6f4a40f28e227619312372232022-12-22T03:48:00ZengBMCThyroid Research1756-66142022-09-011511910.1186/s13044-022-00134-4Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control studyAliakbar Sabermoghaddam0Nasser Shoeibi1Hamid Jafarzadeh2Elham Bakhtiari3Zeinab Salahi4Talieh Saeidi Rezvani5Hamid Reza Heidarzadeh6Mojtaba Abrishami7Eye Research Center, Mashhad University of Medical SciencesEye Research Center, Mashhad University of Medical SciencesEye Research Center, Mashhad University of Medical SciencesEye Research Center, Mashhad University of Medical SciencesEye Research Center, Mashhad University of Medical SciencesDepartment of Education and Psychology, Ferdowsi University of MashhadEye Research Center, Mashhad University of Medical SciencesEye Research Center, Mashhad University of Medical SciencesAbstract Background To evaluate changes in the vessel density (VD) of the optic nerve head (ONH) microvasculature in thyroid eye disease (TED) using optical coherence tomography angiography (OCTA). This study aimed to applicate the OCTA as a noninvasive modality in screening TED patients to assess sub-clinical changes. Methods In a cross-sectional study, the control group patients were healthy individuals with no ocular abnormalities and were euthyroid. All patients with TED had clinical features of the disease. We divided them into two groups using the clinical activity score (CAS). Patients with CAS scores 0–2 were categorized as group A, and scores three or more as group B. All vessels (AV) and small vessels (SV) VD inside disc and radial peripapillary capillary network were measured using the ONH-OCTA. Results We evaluated 29 patients with TED and 28 healthy controls. The mean whole image AV VD (mean ± SD: 56.33 ± 2.56, p-value = 0.17) and the mean whole image SV VD (mean ± SD: 49.94 ± 2.56, p-value = 0.16) in the TED group had no statically significant difference compared with the control group (AV mean ± SD: 57.20 ± 20.22, SV mean ± SD: 50.84 ± 2.23). We found a non-significant decrease in AV and SV radial peripapillary capillary VD in the TED group. There was a significant decrease in the mean whole image AV VD (mean ± SD: 54.83 ± 3.07, p-value = 0.005) and the mean whole image SV VD (mean ± SD: 48.60 ± 3.18, p-value = 0.013) in CAS group B compared to group A (AV mean ± SD: 57.45 ± 1.33, SV mean ± SD: 50.95 ± 1.37). Conclusion Our study showed non-significant ONH vascular alterations in patients with TED, including reduced VD of ONH in the radial peripapillary capillary. Patients with higher CAS scores had a more noticeable decrease in ONH microvasculature.https://doi.org/10.1186/s13044-022-00134-4Thyroid eye diseaseOptical coherence tomography angiographyOptic nerve headRadial peripapillary capillary network |
| spellingShingle | Aliakbar Sabermoghaddam Nasser Shoeibi Hamid Jafarzadeh Elham Bakhtiari Zeinab Salahi Talieh Saeidi Rezvani Hamid Reza Heidarzadeh Mojtaba Abrishami Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study Thyroid Research Thyroid eye disease Optical coherence tomography angiography Optic nerve head Radial peripapillary capillary network |
| title | Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study |
| title_full | Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study |
| title_fullStr | Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study |
| title_full_unstemmed | Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study |
| title_short | Optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease: a case–control study |
| title_sort | optic nerve head optical coherence tomography angiography findings in patients with thyroid eye disease a case control study |
| topic | Thyroid eye disease Optical coherence tomography angiography Optic nerve head Radial peripapillary capillary network |
| url | https://doi.org/10.1186/s13044-022-00134-4 |
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