Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis
Abstract Background The impact of cardiac troponin on the short‐term and long‐term prognosis of patients with sepsis remains uncertain. Therefore, we conducted a meta‐analysis to investigate the role of cardiac troponin as a potential indicator for sepsis mortality. Methods We performed a comprehens...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.1014 |
| _version_ | 1797670731865128960 |
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| author | Peiqiu Zheng Xing Wang Tao Guo Wei Gao Qiang Huang Jie Yang Hui Gao Qian Liu |
| author_facet | Peiqiu Zheng Xing Wang Tao Guo Wei Gao Qiang Huang Jie Yang Hui Gao Qian Liu |
| author_sort | Peiqiu Zheng |
| collection | DOAJ |
| description | Abstract Background The impact of cardiac troponin on the short‐term and long‐term prognosis of patients with sepsis remains uncertain. Therefore, we conducted a meta‐analysis to investigate the role of cardiac troponin as a potential indicator for sepsis mortality. Methods We performed a comprehensive search for articles published before November 2022 using Google Scholar, PubMed, and Web of Science. Inclusion criteria for the studies were: (1) investigation of cardiac troponin, and (2) investigation of sepsis. Exclusion criteria included: (1) inability to obtain or calculate hazard ratio (HR) and 95% confidence interval (CI) for the relationship between cardiac troponin level and sepsis mortality, and (2) reviews, meta‐analyses, and case reports. Analysis of HRs and 95% CIs for the association between cardiac troponin level and sepsis mortality was conducted using STATA 12.0 software. Results Our study included 24 prospective studies (comprising 20,457 sepsis patients) and 4 retrospective studies (comprising 1416 sepsis patients). Meta‐analysis demonstrated that elevated cardiac troponin levels were significantly associated with increased sepsis mortality using a random effects model (HR = 1.57, 95% CI 1.41−1.75). Moreover, elevated cardiac troponin levels were also significantly associated with increased hospital mortality of sepsis (HR = 1.35, 95% CI 1.19−1.53) and long‐term mortality of sepsis (HR = 1.96, 95% CI 1.51−2.55) using the random effects model. Conclusions Overall, our finding revealed that elevated cardiac troponin for sepsis patients was a predictor of hospital and long‐term mortality. Clinicians may treat septic patients with elevated cardiac troponin more cautious to avoid extra death. Moreover, large clinical studies are warranted to validate this association. |
| first_indexed | 2024-03-11T21:03:51Z |
| format | Article |
| id | doaj.art-a188aa135fc545449092cb65e8e72cc1 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-03-11T21:03:51Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-a188aa135fc545449092cb65e8e72cc12023-09-29T16:08:31ZengWileyImmunity, Inflammation and Disease2050-45272023-09-01119n/an/a10.1002/iid3.1014Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysisPeiqiu Zheng0Xing Wang1Tao Guo2Wei Gao3Qiang Huang4Jie Yang5Hui Gao6Qian Liu7Department of Emergency Liyang Hospital of Chinese Medicine Changzhou Jiangsu ChinaDepartment of Critical Care Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu ChinaDepartment of Emergency Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing Jiangsu ChinaDepartment of Critical Care Medicine Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing Jiangsu ChinaDepartment of Emergency Liyang Hospital of Chinese Medicine Changzhou Jiangsu ChinaDepartment of Critical Care Medicine Liyang Hospital of Chinese Medicin Changzhou Jiangsu ChinaDepartment of Critical Care Medicine Liyang Hospital of Chinese Medicin Changzhou Jiangsu ChinaDepartment of Critical Care Medicine Liyang Hospital of Chinese Medicin Changzhou Jiangsu ChinaAbstract Background The impact of cardiac troponin on the short‐term and long‐term prognosis of patients with sepsis remains uncertain. Therefore, we conducted a meta‐analysis to investigate the role of cardiac troponin as a potential indicator for sepsis mortality. Methods We performed a comprehensive search for articles published before November 2022 using Google Scholar, PubMed, and Web of Science. Inclusion criteria for the studies were: (1) investigation of cardiac troponin, and (2) investigation of sepsis. Exclusion criteria included: (1) inability to obtain or calculate hazard ratio (HR) and 95% confidence interval (CI) for the relationship between cardiac troponin level and sepsis mortality, and (2) reviews, meta‐analyses, and case reports. Analysis of HRs and 95% CIs for the association between cardiac troponin level and sepsis mortality was conducted using STATA 12.0 software. Results Our study included 24 prospective studies (comprising 20,457 sepsis patients) and 4 retrospective studies (comprising 1416 sepsis patients). Meta‐analysis demonstrated that elevated cardiac troponin levels were significantly associated with increased sepsis mortality using a random effects model (HR = 1.57, 95% CI 1.41−1.75). Moreover, elevated cardiac troponin levels were also significantly associated with increased hospital mortality of sepsis (HR = 1.35, 95% CI 1.19−1.53) and long‐term mortality of sepsis (HR = 1.96, 95% CI 1.51−2.55) using the random effects model. Conclusions Overall, our finding revealed that elevated cardiac troponin for sepsis patients was a predictor of hospital and long‐term mortality. Clinicians may treat septic patients with elevated cardiac troponin more cautious to avoid extra death. Moreover, large clinical studies are warranted to validate this association.https://doi.org/10.1002/iid3.1014meta‐analysismortalitysepsistroponin |
| spellingShingle | Peiqiu Zheng Xing Wang Tao Guo Wei Gao Qiang Huang Jie Yang Hui Gao Qian Liu Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis Immunity, Inflammation and Disease meta‐analysis mortality sepsis troponin |
| title | Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis |
| title_full | Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis |
| title_fullStr | Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis |
| title_full_unstemmed | Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis |
| title_short | Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis |
| title_sort | cardiac troponin as a prognosticator of mortality in patients with sepsis a systematic review and meta analysis |
| topic | meta‐analysis mortality sepsis troponin |
| url | https://doi.org/10.1002/iid3.1014 |
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