To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients
Introduction: Free radicals released after burn injury lead to vascular endothelial injury and contribute to capillary leakage which in turn leads to burn edema. Antioxidant therapy (Vitamin C), to scavenge these free radicals, is suggested to limit endothelial injury and hence limit capillary leaka...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Indian Journal of Burns |
| Subjects: | |
| Online Access: | http://www.ijburns.com/article.asp?issn=0971-653X;year=2018;volume=26;issue=1;spage=77;epage=82;aulast=Tanwar |
| _version_ | 1818319473235460096 |
|---|---|
| author | Bharti Tanwar Dipan Uppal Rajinder K Mittal Sandeep Kaushal Ramneesh Garg Sheerin Shah Sanjeev Uppal |
| author_facet | Bharti Tanwar Dipan Uppal Rajinder K Mittal Sandeep Kaushal Ramneesh Garg Sheerin Shah Sanjeev Uppal |
| author_sort | Bharti Tanwar |
| collection | DOAJ |
| description | Introduction: Free radicals released after burn injury lead to vascular endothelial injury and contribute to capillary leakage which in turn leads to burn edema. Antioxidant therapy (Vitamin C), to scavenge these free radicals, is suggested to limit endothelial injury and hence limit capillary leakage which in turn leads to reduction in fluid requirement to resuscitate the burn patient.
Materials and Methods: This was a prospective, randomized study of 30 burn patients with 20%–60% burns. Fifteen patients were taken in each group. Group A patients were treated with only RL and Group B were treated with RL and adjuvant Vitamin C infusion. Fluid requirement, urine output, fluid balance, body weight gain, Vitamin C, and malondialdehyde (MDA) levels were noted. The two groups were then compared.
Results: Fluid requirement in Group A was 3.74 ± 0.57 ml/kg/% of burns and in Group B was 2.46 ± 0.54 ml/kg/% of burns. Urine output was 1.05 ± 0.28 ml/kg/h in Group A, and in Group B, it was 1.42 ± 0.39 ml/kg/h. Fluid retention and body weight gain were lower in Group B. MDA levels were significantly lower at 36 h in Group B.
Conclusion: Vitamin C, when given as adjuvant therapy in burns, decreases fluid requirement and lowers the MDA levels showing antioxidant effect of Vitamin C. |
| first_indexed | 2024-12-13T10:09:40Z |
| format | Article |
| id | doaj.art-a18a332e20244b17aa97cd8297c4aac8 |
| institution | Directory Open Access Journal |
| issn | 0971-653X |
| language | English |
| last_indexed | 2024-12-13T10:09:40Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Burns |
| spelling | doaj.art-a18a332e20244b17aa97cd8297c4aac82022-12-21T23:51:28ZengWolters Kluwer Medknow PublicationsIndian Journal of Burns0971-653X2018-01-01261778210.4103/ijb.ijb_21_17To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patientsBharti TanwarDipan UppalRajinder K MittalSandeep KaushalRamneesh GargSheerin ShahSanjeev UppalIntroduction: Free radicals released after burn injury lead to vascular endothelial injury and contribute to capillary leakage which in turn leads to burn edema. Antioxidant therapy (Vitamin C), to scavenge these free radicals, is suggested to limit endothelial injury and hence limit capillary leakage which in turn leads to reduction in fluid requirement to resuscitate the burn patient. Materials and Methods: This was a prospective, randomized study of 30 burn patients with 20%–60% burns. Fifteen patients were taken in each group. Group A patients were treated with only RL and Group B were treated with RL and adjuvant Vitamin C infusion. Fluid requirement, urine output, fluid balance, body weight gain, Vitamin C, and malondialdehyde (MDA) levels were noted. The two groups were then compared. Results: Fluid requirement in Group A was 3.74 ± 0.57 ml/kg/% of burns and in Group B was 2.46 ± 0.54 ml/kg/% of burns. Urine output was 1.05 ± 0.28 ml/kg/h in Group A, and in Group B, it was 1.42 ± 0.39 ml/kg/h. Fluid retention and body weight gain were lower in Group B. MDA levels were significantly lower at 36 h in Group B. Conclusion: Vitamin C, when given as adjuvant therapy in burns, decreases fluid requirement and lowers the MDA levels showing antioxidant effect of Vitamin C.http://www.ijburns.com/article.asp?issn=0971-653X;year=2018;volume=26;issue=1;spage=77;epage=82;aulast=TanwarAntioxidantburn edemacapillary leakagefluid requirementfree radicalsVitamin C |
| spellingShingle | Bharti Tanwar Dipan Uppal Rajinder K Mittal Sandeep Kaushal Ramneesh Garg Sheerin Shah Sanjeev Uppal To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients Indian Journal of Burns Antioxidant burn edema capillary leakage fluid requirement free radicals Vitamin C |
| title | To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients |
| title_full | To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients |
| title_fullStr | To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients |
| title_full_unstemmed | To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients |
| title_short | To evaluate the role of Vitamin C in reducing the resuscitation fluid volume requirement in burned patients |
| title_sort | to evaluate the role of vitamin c in reducing the resuscitation fluid volume requirement in burned patients |
| topic | Antioxidant burn edema capillary leakage fluid requirement free radicals Vitamin C |
| url | http://www.ijburns.com/article.asp?issn=0971-653X;year=2018;volume=26;issue=1;spage=77;epage=82;aulast=Tanwar |
| work_keys_str_mv | AT bhartitanwar toevaluatetheroleofvitamincinreducingtheresuscitationfluidvolumerequirementinburnedpatients AT dipanuppal toevaluatetheroleofvitamincinreducingtheresuscitationfluidvolumerequirementinburnedpatients AT rajinderkmittal toevaluatetheroleofvitamincinreducingtheresuscitationfluidvolumerequirementinburnedpatients AT sandeepkaushal toevaluatetheroleofvitamincinreducingtheresuscitationfluidvolumerequirementinburnedpatients AT ramneeshgarg toevaluatetheroleofvitamincinreducingtheresuscitationfluidvolumerequirementinburnedpatients AT sheerinshah toevaluatetheroleofvitamincinreducingtheresuscitationfluidvolumerequirementinburnedpatients AT sanjeevuppal toevaluatetheroleofvitamincinreducingtheresuscitationfluidvolumerequirementinburnedpatients |