Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer
Background: To explore the predictive value of vascular endothelial growth factor (VEGF)-C and D combined with ultrasonic pathological features for nonsentinel lymph node (NSLN) metastasis in positive sentinel lymph nodes (SLNs) early-stage breast cancer. Methods: To review the clinical data of 170...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-09-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009201 |
| _version_ | 1797664556272582656 |
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| author | Jianzhong Chen Weifeng Li Xinyuan Tang Zhibin Wang Liang Xu Qiuming Liu |
| author_facet | Jianzhong Chen Weifeng Li Xinyuan Tang Zhibin Wang Liang Xu Qiuming Liu |
| author_sort | Jianzhong Chen |
| collection | DOAJ |
| description | Background: To explore the predictive value of vascular endothelial growth factor (VEGF)-C and D combined with ultrasonic pathological features for nonsentinel lymph node (NSLN) metastasis in positive sentinel lymph nodes (SLNs) early-stage breast cancer. Methods: To review the clinical data of 170 SLN-positive early breast cancer patients. We examined VEGF-C and D positive expression in cancerous and paraneoplastic tissues and counted ultrasound and pathological features. Results: The rate of VEGF-C and D positivity in cancer tissues was higher than that in paracancerous tissues (p < 0.05). The rates of VEGF-C and D positivity in the cancer tissues with vascular infiltration, number of SLN positives >2, proportion of SLN positives >0.5, burr sign on ultrasound, and NSLN metastasis were higher than those of patients without vascular infiltration, number of SLN positives ≤2, proportion of SLN positives ≤0.5, no burr sign, and no NSLN metastasis, respectively (p < 0.05). The results also showed that the presence of vascular infiltration and burr sign, a high number of SLN positivity, the percentage of SLN positivity >0.5, VEGF-C and D positivity were all NSLN metastasis independent risk factors for metastasis (p < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) for VEGF-C and D combined with ultrasound and pathological features to predict NSLN metastasis was the highest. Conclusions: The ultrasound and pathological features of SLN-positive early breast cancer patients, such as vascular infiltration, VEGF-C and D positivity, were all independent risk factors for NSLN metastasis, and VEGF-C and D combined with ultrasound and pathological features had high predictive efficacy for NSLN metastasis. It provides reliable indicators to screen for NSLN metastasis in a high-risk group from SLN-positive patients with early-stage breast cancer. |
| first_indexed | 2024-03-11T19:31:00Z |
| format | Article |
| id | doaj.art-a18ac818fb9342c28d457eea473c69c2 |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-11T19:31:00Z |
| publishDate | 2023-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-a18ac818fb9342c28d457eea473c69c22023-10-06T13:17:09ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-09-0150920110.31083/j.ceog5009201S0390-6663(23)02141-3Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast CancerJianzhong Chen0Weifeng Li1Xinyuan Tang2Zhibin Wang3Liang Xu4Qiuming Liu5Department of General Surgery, the Municipal Hospital of Fuzhou, 344300 Fuzhou, Jiangxi, ChinaDepartment of Breast Surgery, Breast Cancer Institute, the Third Hospital of Nanchang, 330009 Nanchang, Jiangxi, ChinaDepartment of General Surgery, the Municipal Hospital of Fuzhou, 344300 Fuzhou, Jiangxi, ChinaDepartment of General Surgery, the Municipal Hospital of Fuzhou, 344300 Fuzhou, Jiangxi, ChinaDepartment of Breast Surgery, Breast Cancer Institute, the Third Hospital of Nanchang, 330009 Nanchang, Jiangxi, ChinaDepartment of Breast Surgery, Breast Cancer Institute, the Third Hospital of Nanchang, 330009 Nanchang, Jiangxi, ChinaBackground: To explore the predictive value of vascular endothelial growth factor (VEGF)-C and D combined with ultrasonic pathological features for nonsentinel lymph node (NSLN) metastasis in positive sentinel lymph nodes (SLNs) early-stage breast cancer. Methods: To review the clinical data of 170 SLN-positive early breast cancer patients. We examined VEGF-C and D positive expression in cancerous and paraneoplastic tissues and counted ultrasound and pathological features. Results: The rate of VEGF-C and D positivity in cancer tissues was higher than that in paracancerous tissues (p < 0.05). The rates of VEGF-C and D positivity in the cancer tissues with vascular infiltration, number of SLN positives >2, proportion of SLN positives >0.5, burr sign on ultrasound, and NSLN metastasis were higher than those of patients without vascular infiltration, number of SLN positives ≤2, proportion of SLN positives ≤0.5, no burr sign, and no NSLN metastasis, respectively (p < 0.05). The results also showed that the presence of vascular infiltration and burr sign, a high number of SLN positivity, the percentage of SLN positivity >0.5, VEGF-C and D positivity were all NSLN metastasis independent risk factors for metastasis (p < 0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve (AUC) for VEGF-C and D combined with ultrasound and pathological features to predict NSLN metastasis was the highest. Conclusions: The ultrasound and pathological features of SLN-positive early breast cancer patients, such as vascular infiltration, VEGF-C and D positivity, were all independent risk factors for NSLN metastasis, and VEGF-C and D combined with ultrasound and pathological features had high predictive efficacy for NSLN metastasis. It provides reliable indicators to screen for NSLN metastasis in a high-risk group from SLN-positive patients with early-stage breast cancer.https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009201positive anterior lymph nodesearly breast cancervascular endothelial growth factornonposterior lymph node metastasis |
| spellingShingle | Jianzhong Chen Weifeng Li Xinyuan Tang Zhibin Wang Liang Xu Qiuming Liu Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer Clinical and Experimental Obstetrics & Gynecology positive anterior lymph nodes early breast cancer vascular endothelial growth factor nonposterior lymph node metastasis |
| title | Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer |
| title_full | Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer |
| title_fullStr | Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer |
| title_full_unstemmed | Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer |
| title_short | Predictive Value of VEGF-C and D Combined with Ultrasound Pathological Features for Nonsentinel Lymph Node Metastasis in SLN-Positive Early-Stage Breast Cancer |
| title_sort | predictive value of vegf c and d combined with ultrasound pathological features for nonsentinel lymph node metastasis in sln positive early stage breast cancer |
| topic | positive anterior lymph nodes early breast cancer vascular endothelial growth factor nonposterior lymph node metastasis |
| url | https://www.imrpress.com/journal/CEOG/50/9/10.31083/j.ceog5009201 |
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