Pharmacokinetic targets of antiretroviral therapy in children and adolescents
Large populations of HIV-infected and exposed infants, children and adolescents are increasingly exposed to antiretroviral therapy throughout dramatic changes of the body composition and maturation process in utero, perinatally and during the later growth and development throughout childhood and pub...
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2013-10-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/111 |
| _version_ | 1819075371305271296 |
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| author | Michael N. Neely Natella Y. Rakhmanina |
| author_facet | Michael N. Neely Natella Y. Rakhmanina |
| author_sort | Michael N. Neely |
| collection | DOAJ |
| description | Large populations of HIV-infected and exposed infants, children and adolescents are increasingly exposed to antiretroviral therapy throughout dramatic changes of the body composition and maturation process in utero, perinatally and during the later growth and development throughout childhood and puberty. The majority of HIV-infected children live in the resource-limited setting where the presence of other significant co-morbidities such as malnutrition, tuberculosis and malaria complicates the selection of the most effective, safe and least toxic combination of antiretroviral drug therapy. This review focuses on the role of the pharmacokinetic factors including clinically important drug-drug interactions on the therapeutic targets of antiretroviral therapy throughout childhood and adolescence.
Proceedings of the 9th International Workshop on Neonatology · Cagliari (Italy) · October 23rd-26th, 2013 · Learned lessons, changing practice and cutting-edge research |
| first_indexed | 2024-12-21T18:24:21Z |
| format | Article |
| id | doaj.art-a18b41838b724219a48aa7f749508577 |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-21T18:24:21Z |
| publishDate | 2013-10-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-a18b41838b724219a48aa7f7495085772022-12-21T18:54:27ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922013-10-0122e020226e02022610.7363/02022683Pharmacokinetic targets of antiretroviral therapy in children and adolescentsMichael N. Neely0Natella Y. Rakhmanina1Division of Pediatric Infectious Diseases and Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles, CA, USADivision of Infectious Diseases, Children’s National Medical Center, Department of Pediatrics, the George Washington University School of Medicine and Health Sciences, Washington, DC, USALarge populations of HIV-infected and exposed infants, children and adolescents are increasingly exposed to antiretroviral therapy throughout dramatic changes of the body composition and maturation process in utero, perinatally and during the later growth and development throughout childhood and puberty. The majority of HIV-infected children live in the resource-limited setting where the presence of other significant co-morbidities such as malnutrition, tuberculosis and malaria complicates the selection of the most effective, safe and least toxic combination of antiretroviral drug therapy. This review focuses on the role of the pharmacokinetic factors including clinically important drug-drug interactions on the therapeutic targets of antiretroviral therapy throughout childhood and adolescence. Proceedings of the 9th International Workshop on Neonatology · Cagliari (Italy) · October 23rd-26th, 2013 · Learned lessons, changing practice and cutting-edge researchhttps://www.jpnim.com/index.php/jpnim/article/view/111hiv/aidspediatricspharmacokineticspharmacodynamicstdm |
| spellingShingle | Michael N. Neely Natella Y. Rakhmanina Pharmacokinetic targets of antiretroviral therapy in children and adolescents Journal of Pediatric and Neonatal Individualized Medicine hiv/aids pediatrics pharmacokinetics pharmacodynamics tdm |
| title | Pharmacokinetic targets of antiretroviral therapy in children and adolescents |
| title_full | Pharmacokinetic targets of antiretroviral therapy in children and adolescents |
| title_fullStr | Pharmacokinetic targets of antiretroviral therapy in children and adolescents |
| title_full_unstemmed | Pharmacokinetic targets of antiretroviral therapy in children and adolescents |
| title_short | Pharmacokinetic targets of antiretroviral therapy in children and adolescents |
| title_sort | pharmacokinetic targets of antiretroviral therapy in children and adolescents |
| topic | hiv/aids pediatrics pharmacokinetics pharmacodynamics tdm |
| url | https://www.jpnim.com/index.php/jpnim/article/view/111 |
| work_keys_str_mv | AT michaelnneely pharmacokinetictargetsofantiretroviraltherapyinchildrenandadolescents AT natellayrakhmanina pharmacokinetictargetsofantiretroviraltherapyinchildrenandadolescents |