High Sensitive C-reactive Protein Level in Relation to Increased Body Mass Index among Non-diabetic Non-hypertensive Women
Introduction: An increased Body Mass Index (BMI) has an adverse effect on the socio-economic and healthcare sectors and may influence metabolic status. High sensitivity C-reactive Protein (hs-CRP) is an emerging biomarker. The association between dyslipidaemia and obesity is well established, an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14459/45887_CE[Ra1]_F(KM)_PF1(AGAK)_PFA(SHU)_PB(AG_SHU)_PF2(SS_OM)_PFA1(OM_KM)_PN(KM).pdf |
| Summary: | Introduction: An increased Body Mass Index (BMI) has an
adverse effect on the socio-economic and healthcare sectors
and may influence metabolic status. High sensitivity C-reactive
Protein (hs-CRP) is an emerging biomarker. The association
between dyslipidaemia and obesity is well established, and has
been found to be the risk factors for CVD.
Aim: To study the relationship of hs-CRP with BMI, lipid profile
and magnesium among obese and overweight non-diabetic
non-hypertensive Sudanese women.
Materials and Methods: A cross-sectional study was
conducted on 90 women in Khartoum state (Sudan), aged
between 20 and 43 years, from June to November 2019. The
study included three groups of women based on BMI. hs-CRP
was measured by using latex immunoturbidimetric method,
lipid profile was evaluated using Biosystems colourimetric
methods and magnesium by a chemical method. Results were
computed using Statistical Package for the Social Sciences
(SPSS) version 20.
Results: There was significant increase in the mean values of
hs-CRP, Total Cholesterol (TC), Triglyceride (TG), Low Density
Lipoprotein Cholesterol (LDL-C), and a significant decrease
in the mean values of High Density Lipoprotein Cholesterol
(HDL-C) and magnesium in obese and overweight women,
when compared to normal body weight women. Pearson’s
correlation coefficient revealed a positive correlation between
hs-CRP, and BMI, Waist-To-Hip Ratio (WHR), TC, TG, and
LDL-C (p-value <0.01).
Conclusion: Overweight and obese women have increased hsCRP and atherogenic lipid profile, suggesting obesity to be a
state of chronic inflammation. hs-CRP can be used to assess
the risk of obesity-related disorders for early intervention. |
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| ISSN: | 2249-782X 0973-709X |