Combination of Antioxidant Enzyme Overexpression and N‐Acetylcysteine Treatment Enhances the Survival of Bone Marrow Mesenchymal Stromal Cells in Ischemic Limb in Mice With Type 2 Diabetes

Combination of Antioxidant Enzyme Overexpression and N‐Acetylcysteine Treatment Enhances the Survival of Bone Marrow Mesenchymal Stromal Cells in Ischemic Limb in Mice With Type 2 Diabetes

Background Therapy with mesenchymal stem cells remains a promising but challenging approach to critical limb ischemia in diabetes because of the dismal cell survival. Methods and Results Critical limb ischemia in type 2 diabetes mouse model was used to explore the impact of diabetic limb ischemia on...

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Bibliographic Details
Main Authors: Qiang Zhu, Hong Hao, Huifang Xu, Yosef Fichman, Yuqi Cui, Chunlin Yang, Meifang Wang, Ron Mittler, Michael A. Hill, Peter J. Cowan, Guangsen Zhang, Xiaoming He, Shenghua Zhou, Zhenguo Liu
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cell therapy
diabetes
ischemic disease
mesenchymal stem cells
oxidative stress
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.023491

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