Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population
Variations in lipid levels are the result of combinations of genetic and environmental factors. We aim to investigate the indirect effect between siblings of the three polymorphisms of ADIPOQ on serum lipid levels in rural Chinese populations. A total of 2571 sibling pairs were enrolled as study par...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/13/1/161 |
| _version_ | 1797493792337559552 |
|---|---|
| author | Zechen Zhou Yujia Ma Xiaoyi Li Zeyu Yan Kexin Ding Han Xiao Yiqun Wu Dafang Chen Tao Wu |
| author_facet | Zechen Zhou Yujia Ma Xiaoyi Li Zeyu Yan Kexin Ding Han Xiao Yiqun Wu Dafang Chen Tao Wu |
| author_sort | Zechen Zhou |
| collection | DOAJ |
| description | Variations in lipid levels are the result of combinations of genetic and environmental factors. We aim to investigate the indirect effect between siblings of the three polymorphisms of ADIPOQ on serum lipid levels in rural Chinese populations. A total of 2571 sibling pairs were enrolled as study participants. A generalized estimating equation was used to accommodate a family-based design. We used stratified analysis to detect sex combination differences in the indirect genetic effect. We found a significant association between the number of altered risk alleles of rs182052 and ego lipid levels of TG (β = 0.177, <i>P</i> = 0.003), TC (β = 0.140, <i>P</i> = 0.004) and LDL-C (β = 0.098, <i>P</i> = 0.014). Ego and altered genotypes of rs182052 demonstrated a joint effect on ego lipid levels of TC (β = 0.212, <i>P</i> = 0.019), HDL-C (β = 0.099, <i>P</i> = 0.002) and LDL-C (β = 0.177, <i>P</i> = 0.013) in recessive inheritance mode. In opposite-sex siblings, the altered GG genotype of rs182052 increased the ego lipid levels. Thus, our findings demonstrate that ADIPOQ has an indirect genetic effect on lipid levels in sibling pairs, and there are sex-combination differences in the indirect genetic effect in siblings. |
| first_indexed | 2024-03-10T01:25:02Z |
| format | Article |
| id | doaj.art-a18cb807a5f742da883ae3ef542070b6 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T01:25:02Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-a18cb807a5f742da883ae3ef542070b62023-11-23T13:53:19ZengMDPI AGGenes2073-44252022-01-0113116110.3390/genes13010161Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese PopulationZechen Zhou0Yujia Ma1Xiaoyi Li2Zeyu Yan3Kexin Ding4Han Xiao5Yiqun Wu6Dafang Chen7Tao Wu8Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, ChinaVariations in lipid levels are the result of combinations of genetic and environmental factors. We aim to investigate the indirect effect between siblings of the three polymorphisms of ADIPOQ on serum lipid levels in rural Chinese populations. A total of 2571 sibling pairs were enrolled as study participants. A generalized estimating equation was used to accommodate a family-based design. We used stratified analysis to detect sex combination differences in the indirect genetic effect. We found a significant association between the number of altered risk alleles of rs182052 and ego lipid levels of TG (β = 0.177, <i>P</i> = 0.003), TC (β = 0.140, <i>P</i> = 0.004) and LDL-C (β = 0.098, <i>P</i> = 0.014). Ego and altered genotypes of rs182052 demonstrated a joint effect on ego lipid levels of TC (β = 0.212, <i>P</i> = 0.019), HDL-C (β = 0.099, <i>P</i> = 0.002) and LDL-C (β = 0.177, <i>P</i> = 0.013) in recessive inheritance mode. In opposite-sex siblings, the altered GG genotype of rs182052 increased the ego lipid levels. Thus, our findings demonstrate that ADIPOQ has an indirect genetic effect on lipid levels in sibling pairs, and there are sex-combination differences in the indirect genetic effect in siblings.https://www.mdpi.com/2073-4425/13/1/161ADIPOQindirect genetic effectlipid levelsibling study |
| spellingShingle | Zechen Zhou Yujia Ma Xiaoyi Li Zeyu Yan Kexin Ding Han Xiao Yiqun Wu Dafang Chen Tao Wu Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population Genes ADIPOQ indirect genetic effect lipid level sibling study |
| title | Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population |
| title_full | Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population |
| title_fullStr | Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population |
| title_full_unstemmed | Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population |
| title_short | Indirect Genetic Effects of ADIPOQ Variants on Lipid Levels in a Sibling Study of a Rural Chinese Population |
| title_sort | indirect genetic effects of adipoq variants on lipid levels in a sibling study of a rural chinese population |
| topic | ADIPOQ indirect genetic effect lipid level sibling study |
| url | https://www.mdpi.com/2073-4425/13/1/161 |
| work_keys_str_mv | AT zechenzhou indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT yujiama indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT xiaoyili indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT zeyuyan indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT kexinding indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT hanxiao indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT yiqunwu indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT dafangchen indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation AT taowu indirectgeneticeffectsofadipoqvariantsonlipidlevelsinasiblingstudyofaruralchinesepopulation |