Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report
Background/ObjectiveChild maltreatment is associated with increased risk of psychological consequences, contributes to morbidity and has long lasting effects on mental health and quality of life. Child maltreatment has not been assessed in patients with pulmonary arterial hypertension (PAH). We exam...
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| Format: | Article |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.812862/full |
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| author | Da-Hee Park Da-Hee Park Tanja Meltendorf Kai G. Kahl Jan C. Kamp Jan C. Kamp Manuel J. Richter Manuel J. Richter Henning Gall Henning Gall Hossein A. Ghofrani Hossein A. Ghofrani Marius M. Hoeper Marius M. Hoeper Karen M. Olsson Karen M. Olsson Jan Fuge Jan Fuge |
| author_facet | Da-Hee Park Da-Hee Park Tanja Meltendorf Kai G. Kahl Jan C. Kamp Jan C. Kamp Manuel J. Richter Manuel J. Richter Henning Gall Henning Gall Hossein A. Ghofrani Hossein A. Ghofrani Marius M. Hoeper Marius M. Hoeper Karen M. Olsson Karen M. Olsson Jan Fuge Jan Fuge |
| author_sort | Da-Hee Park |
| collection | DOAJ |
| description | Background/ObjectiveChild maltreatment is associated with increased risk of psychological consequences, contributes to morbidity and has long lasting effects on mental health and quality of life. Child maltreatment has not been assessed in patients with pulmonary arterial hypertension (PAH). We examined the prevalence of child maltreatment and determined their impact on disease severity in patients with PAH.MethodsA cross-sectional observational multicenter study at two PH centers in Germany was conducted. Patients with a confirmed diagnosis of PAH were given a self-administered questionnaire. Child maltreatment using the Childhood Trauma Questionnaire (CTQ), quality of life (QoL), anxiety, depression, and lifestyle factors were assessed and enhanced by clinical parameters 6-min walk distance (6MWD), WHO functional class (WHO FC), and serum levels of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP). Prevalence rates of child maltreatment were compared to the general population and impact of child maltreatment on disease severity was calculated by logistic regression analysis.ResultsTwo-hundred and seventeen patients, 71% female and a median age of 56 years were enrolled in this study. Patients with PAH had higher rates of emotional abuse and lower rates of physical neglect compared to the German population while rates of emotional neglect, physical abuse, and sexual abuse did not differ between patients and German population. Patients with any form of child maltreatment were more likely to be active smokers, had a worse QoL and more anxiety or depression. Moderate associations between child maltreatment, mental health, QoL, lifestyle factors and clinical parameters could be observed. Logistic regression analysis showed a significant impact of CTQ-total score on disease severity with an OR of 1.022 (95%-CI: 1.001–1.042, p = 0.035).ConclusionWe found a higher rate of child maltreatment in patients with PAH in comparison to the German population. Correlations suggest moderate associations between CTQ-scores and mental health as well as QoL. Child maltreatment had significant impact on disease severity. However, effects were moderate. We conclude that child maltreatment has effects on mental health and quality of life in patients with PAH and may have limited effect on disease severity. |
| first_indexed | 2024-12-19T19:22:46Z |
| format | Article |
| id | doaj.art-a18d936090184a2cac5c07ed25f6f8ed |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-19T19:22:46Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-a18d936090184a2cac5c07ed25f6f8ed2022-12-21T20:08:56ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-02-011310.3389/fpsyt.2022.812862812862Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary ReportDa-Hee Park0Da-Hee Park1Tanja Meltendorf2Kai G. Kahl3Jan C. Kamp4Jan C. Kamp5Manuel J. Richter6Manuel J. Richter7Henning Gall8Henning Gall9Hossein A. Ghofrani10Hossein A. Ghofrani11Marius M. Hoeper12Marius M. Hoeper13Karen M. Olsson14Karen M. Olsson15Jan Fuge16Jan Fuge17Department of Respiratory Medicine, Hannover Medical School, Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hannover, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hannover, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Giessen, GermanyGerman Center for Lung Research, Universities of Giessen and Marburg Lung Center, Giessen, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Giessen, GermanyGerman Center for Lung Research, Universities of Giessen and Marburg Lung Center, Giessen, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Giessen, GermanyGerman Center for Lung Research, Universities of Giessen and Marburg Lung Center, Giessen, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hannover, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Hannover, GermanyBiomedical Research in Endstage and Obstructive Lung Disease Hannover, German Center for Lung Research, Hannover, GermanyBackground/ObjectiveChild maltreatment is associated with increased risk of psychological consequences, contributes to morbidity and has long lasting effects on mental health and quality of life. Child maltreatment has not been assessed in patients with pulmonary arterial hypertension (PAH). We examined the prevalence of child maltreatment and determined their impact on disease severity in patients with PAH.MethodsA cross-sectional observational multicenter study at two PH centers in Germany was conducted. Patients with a confirmed diagnosis of PAH were given a self-administered questionnaire. Child maltreatment using the Childhood Trauma Questionnaire (CTQ), quality of life (QoL), anxiety, depression, and lifestyle factors were assessed and enhanced by clinical parameters 6-min walk distance (6MWD), WHO functional class (WHO FC), and serum levels of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP). Prevalence rates of child maltreatment were compared to the general population and impact of child maltreatment on disease severity was calculated by logistic regression analysis.ResultsTwo-hundred and seventeen patients, 71% female and a median age of 56 years were enrolled in this study. Patients with PAH had higher rates of emotional abuse and lower rates of physical neglect compared to the German population while rates of emotional neglect, physical abuse, and sexual abuse did not differ between patients and German population. Patients with any form of child maltreatment were more likely to be active smokers, had a worse QoL and more anxiety or depression. Moderate associations between child maltreatment, mental health, QoL, lifestyle factors and clinical parameters could be observed. Logistic regression analysis showed a significant impact of CTQ-total score on disease severity with an OR of 1.022 (95%-CI: 1.001–1.042, p = 0.035).ConclusionWe found a higher rate of child maltreatment in patients with PAH in comparison to the German population. Correlations suggest moderate associations between CTQ-scores and mental health as well as QoL. Child maltreatment had significant impact on disease severity. However, effects were moderate. We conclude that child maltreatment has effects on mental health and quality of life in patients with PAH and may have limited effect on disease severity.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.812862/fullpulmonary arterial hypertensionchild maltreatmentmental healthquality of lifeprevalencepulmonary hypertension |
| spellingShingle | Da-Hee Park Da-Hee Park Tanja Meltendorf Kai G. Kahl Jan C. Kamp Jan C. Kamp Manuel J. Richter Manuel J. Richter Henning Gall Henning Gall Hossein A. Ghofrani Hossein A. Ghofrani Marius M. Hoeper Marius M. Hoeper Karen M. Olsson Karen M. Olsson Jan Fuge Jan Fuge Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report Frontiers in Psychiatry pulmonary arterial hypertension child maltreatment mental health quality of life prevalence pulmonary hypertension |
| title | Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report |
| title_full | Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report |
| title_fullStr | Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report |
| title_full_unstemmed | Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report |
| title_short | Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report |
| title_sort | childhood trauma in patients with pah prevalence impact on qol and mental health a preliminary report |
| topic | pulmonary arterial hypertension child maltreatment mental health quality of life prevalence pulmonary hypertension |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.812862/full |
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