Lytic Phages against ST11 K47 Carbapenem-Resistant Klebsiella pneumoniae and the Corresponding Phage Resistance Mechanisms

Lytic Phages against ST11 K47 Carbapenem-Resistant Klebsiella pneumoniae and the Corresponding Phage Resistance Mechanisms

ABSTRACT We isolated and characterized a novel phage from hospital sewage, P13, able to lyse ST11 K47 carbapenem-resistant Klebsiella pneumoniae (CRKP), a major CRKP lineage. P13 formed a large lytic plaque (3.0 to 6.0 mm in diameter) in double-layer LB agar after overnight coculture with its host b...

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Bibliographic Details
Main Authors: Qingqing Fang, Zhiyong Zong
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mSphere
Subjects:
Phage therapy
Klebsiella pneumoniae
K47
capsule
phage resistance
Klebsiella
Online Access:https://journals.asm.org/doi/10.1128/msphere.00080-22

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