CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation

CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation

Abstract Background The small population of glioma stem-like cells (GSCs) contributes to tumor initiation, malignancy, and recurrence in glioblastoma. However, the maintenance of GSC properties in the tumor microenvironment remains unclear. In glioma, non-neoplastic cells create an inflammatory envi...

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Bibliographic Details
Main Authors: Shao-Ming Wang, Hong-Yi Lin, Yen-Lin Chen, Tsung-I Hsu, Jian-Ying Chuang, Tzu-Jen Kao, Chiung-Yuan Ko
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Glioblastoma multiforme
Glioma stem-like cell
CEBPD
PDGFA
Inflammation
Interleukin-1β
Online Access:http://link.springer.com/article/10.1186/s12974-019-1535-z

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