Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals
Tetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported. An investigation into the culturable microbial pop...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-08-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/11/8/2695 |
| _version_ | 1817991790884552704 |
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| author | Brett A. Neilan Susanna A. Wood John A. Kalaitzis Rocky Chau |
| author_facet | Brett A. Neilan Susanna A. Wood John A. Kalaitzis Rocky Chau |
| author_sort | Brett A. Neilan |
| collection | DOAJ |
| description | Tetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported. An investigation into the culturable microbial populations from the TTX-associated blue-ringed octopus Hapalochlaena sp. and sea slug Pleurobranchaea maculata revealed a surprisingly high microbial diversity. Although TTX was not detected among the cultured isolates, PCR screening identifiedsome natural product biosynthesis genes putatively involved in its assembly. This study is the first to report on the microbial diversity of culturable communities from H. maculosa and P. maculata and common natural product biosynthesis genes from their microbiota. We also reassess the production of TTX reported from three bacterial strains isolated from the TTX-containing gastropod Nassarius semiplicatus. |
| first_indexed | 2024-04-14T01:17:02Z |
| format | Article |
| id | doaj.art-a190439cdbda4b7cacacdcc3ab95cc7a |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:17:02Z |
| publishDate | 2013-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-a190439cdbda4b7cacacdcc3ab95cc7a2022-12-22T02:20:48ZengMDPI AGMarine Drugs1660-33972013-08-011182695271210.3390/md11082695Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine AnimalsBrett A. NeilanSusanna A. WoodJohn A. KalaitzisRocky ChauTetrodotoxin (TTX) is a neurotoxin that has been reported from taxonomically diverse organisms across 14 different phyla. The biogenic origin of tetrodotoxin is still disputed, however, TTX biosynthesis by host-associated bacteria has been reported. An investigation into the culturable microbial populations from the TTX-associated blue-ringed octopus Hapalochlaena sp. and sea slug Pleurobranchaea maculata revealed a surprisingly high microbial diversity. Although TTX was not detected among the cultured isolates, PCR screening identifiedsome natural product biosynthesis genes putatively involved in its assembly. This study is the first to report on the microbial diversity of culturable communities from H. maculosa and P. maculata and common natural product biosynthesis genes from their microbiota. We also reassess the production of TTX reported from three bacterial strains isolated from the TTX-containing gastropod Nassarius semiplicatus.http://www.mdpi.com/1660-3397/11/8/2695tetrodotoxinbiosynthesismicrobial diversityPleurobranchaea maculataHapalochlaena sp.Nassarius semiplicatus |
| spellingShingle | Brett A. Neilan Susanna A. Wood John A. Kalaitzis Rocky Chau Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals Marine Drugs tetrodotoxin biosynthesis microbial diversity Pleurobranchaea maculata Hapalochlaena sp. Nassarius semiplicatus |
| title | Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals |
| title_full | Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals |
| title_fullStr | Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals |
| title_full_unstemmed | Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals |
| title_short | Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals |
| title_sort | diversity and biosynthetic potential of culturable microbes associated with toxic marine animals |
| topic | tetrodotoxin biosynthesis microbial diversity Pleurobranchaea maculata Hapalochlaena sp. Nassarius semiplicatus |
| url | http://www.mdpi.com/1660-3397/11/8/2695 |
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