Protein intrinsic disorder toolbox for comparative analysis of viral proteins
<p>Abstract</p> <p>To examine the usefulness of protein disorder predictions as a tool for the comparative analysis of viral proteins, a relational database has been constructed. The database includes proteins from influenza A and HIV-related viruses. Annotations include viral prot...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-09-01
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| Series: | BMC Genomics |
| _version_ | 1818789158815006720 |
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| author | Uversky Vladimir N Dunker A Keith Goh Gerard |
| author_facet | Uversky Vladimir N Dunker A Keith Goh Gerard |
| author_sort | Uversky Vladimir N |
| collection | DOAJ |
| description | <p>Abstract</p> <p>To examine the usefulness of protein disorder predictions as a tool for the comparative analysis of viral proteins, a relational database has been constructed. The database includes proteins from influenza A and HIV-related viruses. Annotations include viral protein sequence, disorder prediction, structure, and function. Location of each protein within a virion, if known, is also denoted. Our analysis reveals a clear relationship between proximity to the RNA core and the percentage of predicted disordered residues for a set of influenza A virus proteins.</p> <p>Neuraminidases (NA) and hemagglutinin (HA) of major influenza A pandemics tend to pair in such a way that both proteins tend to be either ordered-ordered or disordered-disordered by prediction. This may be the result of these proteins evolving from being lipid-associated. High abundance of intrinsic disorder in envelope and matrix proteins from HIV-related viruses likely represents a mechanism where HIV virions can escape immune response despite the availability of antibodies for the HIV-related proteins. This exercise provides an example showing how the combined use of intrinsic disorder predictions and relational databases provides an improved understanding of the functional and structural behaviour of viral proteins.</p> |
| first_indexed | 2024-12-18T14:35:07Z |
| format | Article |
| id | doaj.art-a19083be41004823b8717e4f7ce6f319 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-18T14:35:07Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-a19083be41004823b8717e4f7ce6f3192022-12-21T21:04:31ZengBMCBMC Genomics1471-21642008-09-019Suppl 2S410.1186/1471-2164-9-S2-S4Protein intrinsic disorder toolbox for comparative analysis of viral proteinsUversky Vladimir NDunker A KeithGoh Gerard<p>Abstract</p> <p>To examine the usefulness of protein disorder predictions as a tool for the comparative analysis of viral proteins, a relational database has been constructed. The database includes proteins from influenza A and HIV-related viruses. Annotations include viral protein sequence, disorder prediction, structure, and function. Location of each protein within a virion, if known, is also denoted. Our analysis reveals a clear relationship between proximity to the RNA core and the percentage of predicted disordered residues for a set of influenza A virus proteins.</p> <p>Neuraminidases (NA) and hemagglutinin (HA) of major influenza A pandemics tend to pair in such a way that both proteins tend to be either ordered-ordered or disordered-disordered by prediction. This may be the result of these proteins evolving from being lipid-associated. High abundance of intrinsic disorder in envelope and matrix proteins from HIV-related viruses likely represents a mechanism where HIV virions can escape immune response despite the availability of antibodies for the HIV-related proteins. This exercise provides an example showing how the combined use of intrinsic disorder predictions and relational databases provides an improved understanding of the functional and structural behaviour of viral proteins.</p> |
| spellingShingle | Uversky Vladimir N Dunker A Keith Goh Gerard Protein intrinsic disorder toolbox for comparative analysis of viral proteins BMC Genomics |
| title | Protein intrinsic disorder toolbox for comparative analysis of viral proteins |
| title_full | Protein intrinsic disorder toolbox for comparative analysis of viral proteins |
| title_fullStr | Protein intrinsic disorder toolbox for comparative analysis of viral proteins |
| title_full_unstemmed | Protein intrinsic disorder toolbox for comparative analysis of viral proteins |
| title_short | Protein intrinsic disorder toolbox for comparative analysis of viral proteins |
| title_sort | protein intrinsic disorder toolbox for comparative analysis of viral proteins |
| work_keys_str_mv | AT uverskyvladimirn proteinintrinsicdisordertoolboxforcomparativeanalysisofviralproteins AT dunkerakeith proteinintrinsicdisordertoolboxforcomparativeanalysisofviralproteins AT gohgerard proteinintrinsicdisordertoolboxforcomparativeanalysisofviralproteins |