Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats
Citrus aurantium L., commonly known as bitter orange, is widely used in folk medicine, but there is little data in the literature about the effects on pregnancy. The aim of the present study was to evaluate the influence of essential oil obtained from fruits of Citrus aurantium on the maternal repro...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2015-03-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100407&lng=en&tlng=en |
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| author | Gustavo T. Volpato Luis A.D. Francia-Farje Débora C. Damasceno Renata V. Oliveira Clélia A. Hiruma-Lima Wilma G. Kempinas |
| author_facet | Gustavo T. Volpato Luis A.D. Francia-Farje Débora C. Damasceno Renata V. Oliveira Clélia A. Hiruma-Lima Wilma G. Kempinas |
| author_sort | Gustavo T. Volpato |
| collection | DOAJ |
| description | Citrus aurantium L., commonly known as bitter orange, is widely used in folk medicine, but there is little data in the literature about the effects on pregnancy. The aim of the present study was to evaluate the influence of essential oil obtained from fruits of Citrus aurantium on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant Wistar rats were randomized into four groups (n minimum = 12 animals/group): G1 = control, G2 to G4 = treated with essential oil from C. aurantium at dose 125, 250 and 500 mg/kg, respectively. Rats were orally treated, by gavage, with plant essential oil or vehicle during pre-implantation and organogenic period (gestational day 0-14). On gestational day 20 the rats were anaesthetized and the gravid uterus was weighed with its contents and the fetuses were analyzed. Results showed that the treated group with 500 mg/kg presented decreased placental weights and placental index, although the treatment with bitter orange essential oil did not show any alteration in maternal reproductive performance, toxicological effect, changes in ossification sites, and malformation index. In conclusion, the treatment of Citrus aurantium essential oil was not teratogenic and did not alter the maternal reproductive outcome. |
| first_indexed | 2024-04-13T01:15:38Z |
| format | Article |
| id | doaj.art-a19285b3bebb443099a38e3f5c1bc382 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-13T01:15:38Z |
| publishDate | 2015-03-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-a19285b3bebb443099a38e3f5c1bc3822022-12-22T03:08:57ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902015-03-0187140741510.1590/0001-3765201520140354S0001-37652015000100407Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in ratsGustavo T. VolpatoLuis A.D. Francia-FarjeDébora C. DamascenoRenata V. OliveiraClélia A. Hiruma-LimaWilma G. KempinasCitrus aurantium L., commonly known as bitter orange, is widely used in folk medicine, but there is little data in the literature about the effects on pregnancy. The aim of the present study was to evaluate the influence of essential oil obtained from fruits of Citrus aurantium on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant Wistar rats were randomized into four groups (n minimum = 12 animals/group): G1 = control, G2 to G4 = treated with essential oil from C. aurantium at dose 125, 250 and 500 mg/kg, respectively. Rats were orally treated, by gavage, with plant essential oil or vehicle during pre-implantation and organogenic period (gestational day 0-14). On gestational day 20 the rats were anaesthetized and the gravid uterus was weighed with its contents and the fetuses were analyzed. Results showed that the treated group with 500 mg/kg presented decreased placental weights and placental index, although the treatment with bitter orange essential oil did not show any alteration in maternal reproductive performance, toxicological effect, changes in ossification sites, and malformation index. In conclusion, the treatment of Citrus aurantium essential oil was not teratogenic and did not alter the maternal reproductive outcome.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100407&lng=en&tlng=enCitrus aurantiumóleo essenciallimo nenomalformaçãoprenhezdesempenho reprodutivo |
| spellingShingle | Gustavo T. Volpato Luis A.D. Francia-Farje Débora C. Damasceno Renata V. Oliveira Clélia A. Hiruma-Lima Wilma G. Kempinas Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats Anais da Academia Brasileira de Ciências Citrus aurantium óleo essencial limo neno malformação prenhez desempenho reprodutivo |
| title | Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats |
| title_full | Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats |
| title_fullStr | Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats |
| title_full_unstemmed | Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats |
| title_short | Effect of essential oil from Citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats |
| title_sort | effect of essential oil from citrus aurantium in maternal reproductive outcome and fetal anomaly frequency in rats |
| topic | Citrus aurantium óleo essencial limo neno malformação prenhez desempenho reprodutivo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100407&lng=en&tlng=en |
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