The bidirectional relationship between endometriosis and microbiome
Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1110824/full |
| _version_ | 1827997667706273792 |
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| author | Cansu Uzuner Jason Mak Fatima El-Assaad George Condous |
| author_facet | Cansu Uzuner Jason Mak Fatima El-Assaad George Condous |
| author_sort | Cansu Uzuner |
| collection | DOAJ |
| description | Endometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in the formation and progression of endometriosis via inflammatory pathways. The dysbiosis seen in endometriosis is thought to be both causative and a consequence of the pathogenesis. Gut, peritoneal fluid and female reproductive tract microbiota has been studied to understand if there are any microbiome signatures specific to endometriosis. New research on how to manipulate the microbiome for better detection and treatment of endometriosis is emerging. |
| first_indexed | 2024-04-10T05:32:35Z |
| format | Article |
| id | doaj.art-a1929dcdd4e64cf38e8c04348659d46c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T05:32:35Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a1929dcdd4e64cf38e8c04348659d46c2023-03-07T05:55:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.11108241110824The bidirectional relationship between endometriosis and microbiomeCansu Uzuner0Jason Mak1Fatima El-Assaad2George Condous3Endometriosis Ultrasound and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Sydney, NSW, AustraliaEndometriosis Ultrasound and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Sydney, NSW, AustraliaUniversity of New South Wales Microbiome Research Centre, St. George and Sutherland Clinical Campuses, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, AustraliaEndometriosis Ultrasound and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Sydney, NSW, AustraliaEndometriosis has been described by many different theories of pathogenesis over the years. It is now also appreciated to be a state of chronic inflammation, and the role of immune dysfunction in its development has been proven. There is increasing evidence to support the role of the microbiome in the formation and progression of endometriosis via inflammatory pathways. The dysbiosis seen in endometriosis is thought to be both causative and a consequence of the pathogenesis. Gut, peritoneal fluid and female reproductive tract microbiota has been studied to understand if there are any microbiome signatures specific to endometriosis. New research on how to manipulate the microbiome for better detection and treatment of endometriosis is emerging.https://www.frontiersin.org/articles/10.3389/fendo.2023.1110824/fullendometriosismicrobiomemicrobiotadysbiosisinflammationimmune response |
| spellingShingle | Cansu Uzuner Jason Mak Fatima El-Assaad George Condous The bidirectional relationship between endometriosis and microbiome Frontiers in Endocrinology endometriosis microbiome microbiota dysbiosis inflammation immune response |
| title | The bidirectional relationship between endometriosis and microbiome |
| title_full | The bidirectional relationship between endometriosis and microbiome |
| title_fullStr | The bidirectional relationship between endometriosis and microbiome |
| title_full_unstemmed | The bidirectional relationship between endometriosis and microbiome |
| title_short | The bidirectional relationship between endometriosis and microbiome |
| title_sort | bidirectional relationship between endometriosis and microbiome |
| topic | endometriosis microbiome microbiota dysbiosis inflammation immune response |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1110824/full |
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