ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review
A 32‐year‐old woman was referred to our hospital because of severe psychosis and was found to have an ectopic ACTH‐producing thymic neuroendocrine tumor. Laboratory data revealed an elevated serum cortisol and plasma ACTH level, hypokalemia, and metabolic alkalosis. Chest computed tomography (CT) re...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-07-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.13099 |
| _version_ | 1819150937168543744 |
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| author | Taiki Okumura Shohei Takayama Shin‐ichi Nishio Takahiro Miyakoshi Takuro Noguchi Takashi Kobayashi Toshirou Fukushima Nodoka Sekiguchi Toshiaki Otsuki Mitsuhisa Komatsu Tomonobu Koizumi |
| author_facet | Taiki Okumura Shohei Takayama Shin‐ichi Nishio Takahiro Miyakoshi Takuro Noguchi Takashi Kobayashi Toshirou Fukushima Nodoka Sekiguchi Toshiaki Otsuki Mitsuhisa Komatsu Tomonobu Koizumi |
| author_sort | Taiki Okumura |
| collection | DOAJ |
| description | A 32‐year‐old woman was referred to our hospital because of severe psychosis and was found to have an ectopic ACTH‐producing thymic neuroendocrine tumor. Laboratory data revealed an elevated serum cortisol and plasma ACTH level, hypokalemia, and metabolic alkalosis. Chest computed tomography (CT) revealed an anterior mediastinal mass and multiple pulmonary nodules. As the patient was unable to communicate because of her consciousness disturbance, she was managed with artificial ventilation and deep sedation. Metyrapone and potassium supplementation were administered, and steroid psychosis gradually improved. Thoracic surgery was performed and the histopathological diagnosis was thymic neuroendocrine tumor with positive anti‐ACTH immunohistochemical staining. Here we present details of the case and review the literature. |
| first_indexed | 2024-12-22T14:25:26Z |
| format | Article |
| id | doaj.art-a19388b6c3c146e6bbbe8def67003213 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-12-22T14:25:26Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-a19388b6c3c146e6bbbe8def670032132022-12-21T18:22:53ZengWileyThoracic Cancer1759-77061759-77142019-07-011071648165310.1111/1759-7714.13099ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature reviewTaiki Okumura0Shohei Takayama1Shin‐ichi Nishio2Takahiro Miyakoshi3Takuro Noguchi4Takashi Kobayashi5Toshirou Fukushima6Nodoka Sekiguchi7Toshiaki Otsuki8Mitsuhisa Komatsu9Tomonobu Koizumi10Second Department of Internal Medicine Shinshu University School of Medicine Asahi Matsumoto JapanFourth Department of Internal Medicine Shinshu University School of Medicine Asahi Matsumoto JapanFourth Department of Internal Medicine Shinshu University School of Medicine Asahi Matsumoto JapanFourth Department of Internal Medicine Shinshu University School of Medicine Asahi Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Asahi Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Asahi Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Asahi Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Asahi Matsumoto JapanDepartment of Central Laboratory Shinshu University School of Medicine Asahi Matsumoto JapanFourth Department of Internal Medicine Shinshu University School of Medicine Asahi Matsumoto JapanDepartment of Comprehensive Cancer Therapy Shinshu University School of Medicine Asahi Matsumoto JapanA 32‐year‐old woman was referred to our hospital because of severe psychosis and was found to have an ectopic ACTH‐producing thymic neuroendocrine tumor. Laboratory data revealed an elevated serum cortisol and plasma ACTH level, hypokalemia, and metabolic alkalosis. Chest computed tomography (CT) revealed an anterior mediastinal mass and multiple pulmonary nodules. As the patient was unable to communicate because of her consciousness disturbance, she was managed with artificial ventilation and deep sedation. Metyrapone and potassium supplementation were administered, and steroid psychosis gradually improved. Thoracic surgery was performed and the histopathological diagnosis was thymic neuroendocrine tumor with positive anti‐ACTH immunohistochemical staining. Here we present details of the case and review the literature.https://doi.org/10.1111/1759-7714.13099Mediastinal carcinoidmental disorderneuroendocrine carcinomapulmonary metastasissevere psychosis |
| spellingShingle | Taiki Okumura Shohei Takayama Shin‐ichi Nishio Takahiro Miyakoshi Takuro Noguchi Takashi Kobayashi Toshirou Fukushima Nodoka Sekiguchi Toshiaki Otsuki Mitsuhisa Komatsu Tomonobu Koizumi ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review Thoracic Cancer Mediastinal carcinoid mental disorder neuroendocrine carcinoma pulmonary metastasis severe psychosis |
| title | ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review |
| title_full | ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review |
| title_fullStr | ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review |
| title_full_unstemmed | ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review |
| title_short | ACTH‐producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review |
| title_sort | acth producing thymic neuroendocrine tumor initially presenting as psychosis a case report and literature review |
| topic | Mediastinal carcinoid mental disorder neuroendocrine carcinoma pulmonary metastasis severe psychosis |
| url | https://doi.org/10.1111/1759-7714.13099 |
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